Chemical Information
Antiviral agent ID	DrugRepV_7392
Antiviral agent name	Epicatechin
IUPAC Name	(2~{R},3~{R})-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2~{H}-chromene-3,5,7-triol
SMILES (canonical)	C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O
SMILES (isomeric)	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O
Molecular Formula	C15H14O6
Molecular Weight (g/mol)	290.271
InChl	InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1
Synonyms	(-)-Epicatechin | l-Acacatechin | (2R,3R)-(-)-Epicatechin | (+/-)-Catechin hydrate
Structural Information
Clinical Information
Primary Indication (Clinical trial phases)	Investigational
Biological Information
Primary Indication (Disease Category)	Non infectious Disease
Primary Indication (Disease)	Pre-diabetes
Secondary Indication	West Nile virus (WNV) NA NY-99
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Vero
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	0.5 PFU/cell
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection (1 hour)
Secondary Indication (Duration of drug delivery)	24 hours
Secondary Indication (Drug concentration)	10 μM
Secondary Indication (Cell based assay)	Plaque assay
Secondary Indication (Change)	No significant effect
Secondary Indication (Type of Inhibition)	Log reduction [ No significant effect Log ]
Reference	Vazquez-Calvo A, Jimenez de Oya N, Martin-Acebes MA, Garcia-Moruno E, Saiz JC..Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the.Front Microbiol. 2017 Jul 11;8:1314. doi: 10.3389/fmicb.2017.01314. eCollection 2017. PubMed Central PMID:28744282
Comment	Delphinidin and epigallocatechin gallate showed a direct effect on WNV particles exerting a virucidal effect. Both polyphenols also reduced the infectivity of ZIKV and DENV.