Chemical Information
Antiviral agent ID	DrugRepV_7358
Antiviral agent name	DL-Asparagine-Zn
Structural Information
2-D Structure is not available	3-D Structure is not available
Clinical Information
Biological Information
Secondary Indication	Japanese encephalitis virus (JEV) NA Nakayama
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vivo
Secondary Indication (Model system) [cell lines/ animal models]	Mice
Secondary Indication (Mode of viral infection)	Intraperitoneal
Secondary Indication (Viral titer)	0.01 LD50
Secondary Indication (Mode of drug delivery)	Intraperitoneal
Secondary Indication (Time of drug delivery)	Post infection (72 hours)
Secondary Indication (Duration of drug delivery)	2 weeks
Secondary Indication (Drug concentration)	25 mg/kg
Secondary Indication (Cell based assay)	Paralysis
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Percentage paralysis [ 36.36 % ]
Reference	AKIHAMA S, TOYOSHIMA S..Antiviral effect of zinc complexes on Japanese B encephalitis virus..Chem Pharm Bull (Tokyo). 1962 Dec;10:1254-7. PMID:14011545
Comment	A curative effect on patients suffering from Japanese B encephalitis (90% of patients were completly cured) was obtained by the simultaneous administration of erythro-1-(p-tolyl)-2-aminopropanol methansulfonate and ACTH-Zn, and asserted that such a synergistic action was not observed with other adrenocortical steroid drugs and ACTH preparation containing no zinc.