Chemical Information | |
Antiviral agent ID | DrugRepV_7302 | |
Antiviral agent name | (3E)-N-tert-butyl-4-(4-methoxyphenyl)-2-oxobut-3-enamide | |
IUPAC Name | (3E)-N-tert-butyl-4-(4-methoxyphenyl)-2-oxobut-3-enamide | |
SMILES (canonical) | COC1=CC=C(\C=C\C(=O)C(=O)NC(C)(C)C)C=C1 | |
Molecular Formula | C15H19NO3 | |
Molecular Weight (g/mol) | 261.321 | |
InChl | InChI=1S/C15H19NO3/c1-15(2,3)16-14(18)13(17)10-7-11-5-8-12(19-4)9-6-11/h5-10H,1-4H3,(H,16,18)/b10-7+ | |
Structural Information | |
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Clinical Information | |
Biological Information | |
Secondary Indication | West Nile virus (WNV) NA NA | |
Secondary Indication (Approaches) | Experimental | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Drug concentration) | 50 μM
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Secondary Indication (Cell based assay) | Protease assay
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Secondary Indication (Change) | Decrease
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Secondary Indication (Type of Inhibition) | Percentage Inhibition [ 27.3 % ] | |
Reference | Steuer C, Gege C, Fischl W, Heinonen KH, Bartenschlager R, Klein CD..Synthesis and biological evaluation of ?-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture..Bioorg Med Chem. 2011 Jul 1;19(13):4067-74. doi: 10.1016/j.bmc.2011.05.015. Epub 2011 May 18. PMID:21641807
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Comment | NA
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