Chemical, Structural, Clinical and Biological details of Antiviral agents ID: DrugRepV_7302



Chemical Information
Antiviral agent IDDrugRepV_7302
Antiviral agent name(3E)-N-tert-butyl-4-(4-methoxyphenyl)-2-oxobut-3-enamide
IUPAC Name(3E)-N-tert-butyl-4-(4-methoxyphenyl)-2-oxobut-3-enamide PubChem
SMILES (canonical)COC1=CC=C(\C=C\C(=O)C(=O)NC(C)(C)C)C=C1 PubChem
Molecular FormulaC15H19NO3 PubChem
Molecular Weight (g/mol)261.321 PubChem
InChlInChI=1S/C15H19NO3/c1-15(2,3)16-14(18)13(17)10-7-11-5-8-12(19-4)9-6-11/h5-10H,1-4H3,(H,16,18)/b10-7+ PubChem
Structural Information
  
Clinical Information
Biological Information
Secondary Indication West Nile virus (WNV) NA NAWorld Health OrganisationCDC
Secondary Indication (Approaches)Experimental
Secondary Indication (Methods)In-vitro
Secondary Indication (Mode of drug delivery) Culture
Secondary Indication (Drug concentration)50 μM
Secondary Indication (Cell based assay)Protease assay
Secondary Indication (Change)Decrease
Secondary Indication (Type of Inhibition) Percentage Inhibition [ 27.3 % ]
ReferenceSteuer C, Gege C, Fischl W, Heinonen KH, Bartenschlager R, Klein CD..Synthesis and biological evaluation of ?-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture..Bioorg Med Chem. 2011 Jul 1;19(13):4067-74. doi: 10.1016/j.bmc.2011.05.015. Epub 2011 May 18. PMID:21641807 PubMed
CommentNA