| Chemical Information | |
| Antiviral agent ID | DrugRepV_7291 | |
| Antiviral agent name | Cdt yellow | |
| Structural Information | |
| 2-D Structure is not available | 3-D Structure is not available |
| Clinical Information | |
| Biological Information | |
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Secondary Indication | Yellow fever virus (YFV) NA 17D |   |
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Secondary Indication (Approaches) | Experimental | |
| Secondary Indication (Methods) | In-vitro | |
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Secondary Indication (Model system) [cell lines/ animal models] | VeroE6
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Secondary Indication (Mode of viral infection) | Adsorption
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Drug concentration) | 28.7 ± 3.3 ng/μL
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Secondary Indication (Cell based assay) | Internalization assay
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Secondary Indication (Change) | Decrease
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Secondary Indication (Type of Inhibition) | EC50 [ 50 % ] | |
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Reference | Muller VD, Russo RR, Cintra AC, Sartim MA, Alves-Paiva Rde M, Figueiredo LT, Sampaio SV, Aquino VH..Crotoxin and phospholipases A? from Crotalus durissus terrificus showed antiviral activity against dengue and yellow fever viruses..Toxicon. 2012 Mar 15;59(4):507-15. doi: 10.1016/j.toxicon.2011.05.021. Epub 2011 Jun 23. PMID:21723310
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Comment | The antiviral activity of crude venom and isolated toxins from Crotalus durissus terrificus was evaluated and found that phospholipases A2 showed a high inhibition of Yellow fever and dengue viruses in VERO E6 cells.
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