Chemical Information
Antiviral agent ID	DrugRepV_7215
Antiviral agent name	CCG-4088
IUPAC Name	N-[1-[(4-acetylphenyl)carbamothioylamino]-2,2,2-trichloroethyl]-2-naphthalen-1-ylacetamide
SMILES (canonical)	CC(=O)C1=CC=C(C=C1)NC(=S)NC(C(Cl)(Cl)Cl)NC(=O)CC2=CC=CC3=CC=CC=C32
Molecular Formula	C23H20Cl3N3O2S
Molecular Weight (g/mol)	508.842
InChl	InChI=1S/C23H20Cl3N3O2S/c1-14(30)15-9-11-18(12-10-15)27-22(32)29-21(23(24,25)26)28-20(31)13-17-7-4-6-16-5-2-3-8-19(16)17/h2-12,21H,13H2,1H3,(H,28,31)(H2,27,29,32)
Structural Information
Clinical Information
Biological Information
Secondary Indication	Yellow fever virus (YFV) NA YFV 17D
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	BHK-15
Secondary Indication (Mode of viral infection)	Transfection
Secondary Indication (Viral titer)	1 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection
Secondary Indication (Duration of drug delivery)	24 hours
Secondary Indication (Drug concentration)	0.01 + 0.1 μM
Secondary Indication (Cell based assay)	Luciferase assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Relative luciferase activity [ 42 % ]
Reference	Patkar CG, Larsen M, Owston M, Smith JL, Kuhn RJ..Identification of inhibitors of yellow fever virus replication using a replicon-based high-throughput assay..Antimicrob Agents Chemother. 2009 Oct;53(10):4103-14. doi: 10.1128/AAC.00074-09. Epub 2009 Aug 3. Pu PMID:19651907
Comment	Tested in combination with CCG-3394. Yellow Fever Virus mutants that escaped inhibition of two compounds (4088 and 3394) were isolated, and the mutations were mapped to the NS4B coding region that suggest a novel inhibitory target for these compounds.