Chemical Information
Antiviral agent ID	DrugRepV_6893
Antiviral agent name	4-(3-(4-(benzyloxy)phenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
IUPAC Name	4-{3-[4-(benzyloxy)phenyl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}benzene-1-sulfonamide
SMILES (canonical)	[H]N([H])S(=O)(=O)C1=CC=C(C=C1)N1N=C(CC1C1=CC=C(Cl)C=C1)C1=CC=C(OCC2=CC=CC=C2)C=C1
Molecular Formula	C28H24ClN3O3S
Molecular Weight (g/mol)	518.03
InChl	InChI=1/C28H24ClN3O3S/c29-23-10-6-22(7-11-23)28-18-27(31-32(28)24-12-16-26(17-13-24)36(30,33)34)21-8-14-25(15-9-21)35-19-20-4-2-1-3-5-20/h1-17,28H,18-19H2,(H2,30,33,34)
Structural Information
Clinical Information
Biological Information
Secondary Indication	Human immunodeficiency virus (HIV) 1 NA
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	BHK-21
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	0.01 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	>70 μM
Secondary Indication (Cell based assay)	MTT assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	EC50 [ 50 % ]
Secondary Indication (Cytotoxicity)	16 μM
Reference	Fioravanti R, Desideri N, Carta A, Atzori EM, Delogu I, Collu G, Loddo R..Inhibitors of Yellow Fever Virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: Design, synthesis and antiviral evaluation..Eur J Med Chem. 2017 Dec 1;141:15-25. doi: 10.1016/j.ejmech.2017.09.060. Epub 2017 Sep 28. PMID:29028528
Comment	6-Azauridine, ribavirin, 2'-C-methyl-guanosin (NM108), efavirenz (EFV), pleconaril, acyclovir (ACG), and mycophenolic acid (M5255) were employed as reference inhibitors.