Chemical Information
Antiviral agent ID	DrugRepV_6157
Antiviral agent name	Schisandrin A
IUPAC Name	(9R,10S)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene
SMILES (canonical)	CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1C)OC)OC)OC)OC)OC)OC
SMILES (isomeric)	C[C@@H]1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3C[C@@H]1C)OC)OC)OC)OC)OC)OC
Molecular Formula	C24H32O6
Molecular Weight (g/mol)	416.514
InChl	InChI=1S/C24H32O6/c1-13-9-15-11-17(25-3)21(27-5)23(29-7)19(15)20-16(10-14(13)2)12-18(26-4)22(28-6)24(20)30-8/h11-14H,9-10H2,1-8H3/t13-,14+
Structural Information
Clinical Information
Biological Information
Secondary Indication	Dengue virus (DENV) NA NA
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Huh-7
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection
Secondary Indication (Duration of drug delivery)	6 days
Secondary Indication (Drug concentration)	5 mg/kg
Secondary Indication (Cell based assay)	Survival assay
Secondary Indication (Change)	Decrease
Secondary Indication (Survival rate)	80
Reference	Yu JS, Wu YH, Tseng CK, Lin CK, Hsu YC, Chen YH, Lee JC..Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway..Sci Rep. 2017 Mar 24;7:45171. doi: 10.1038/srep45171. PubMed Central PMCID: PMC5364541. PMID:28338050
Comment	Schisandrin A can e ectively protect mice from DENV infection by reducing disease symptoms and mortality of DENV-infected mice.