Chemical Information | |
Antiviral agent ID | DrugRepV_6060 | |
Antiviral agent name | 4-(3-(4-(benzyloxy)phenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide | |
IUPAC Name | 4-{3-[4-(benzyloxy)phenyl]-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl}benzene-1-sulfonamide | |
SMILES (canonical) | [H]N([H])S(=O)(=O)C1=CC=C(C=C1)N1N=C(CC1C1=CC=CC=C1C)C1=CC=C(OCC2=CC=CC=C2)C=C1 | |
Molecular Formula | C29H27N3O3S | |
Molecular Weight (g/mol) | 497.61 | |
InChl | InChI=1/C29H27N3O3S/c1-21-7-5-6-10-27(21)29-19-28(31-32(29)24-13-17-26(18-14-24)36(30,33)34)23-11-15-25(16-12-23)35-20-22-8-3-2-4-9-22/h2-18,29H,19-20H2,1H3,(H2,30,33,34) | |
Structural Information | |
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Clinical Information | |
Biological Information | |
Secondary Indication | Dengue virus (DENV) 2 Clinical isolate | |
Secondary Indication (Approaches) | Experimental | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | BHK-21
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Secondary Indication (Mode of viral infection) | Adsorption
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Secondary Indication (Viral titer) | 0.01 MOI
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Drug concentration) | >22 μM
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Secondary Indication (Cell based assay) | MTT assay
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Secondary Indication (Change) | Decrease
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Secondary Indication (Type of Inhibition) | EC50 [ 50 % ] | |
Secondary Indication (Cytotoxicity) | 22 ± 3 μM | |
Reference | Fioravanti R, Desideri N, Carta A, Atzori EM, Delogu I, Collu G, Loddo R..Inhibitors of Yellow Fever Virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: Design, synthesis and antiviral evaluation..Eur J Med Chem. 2017 Dec 1;141:15-25. doi: 10.1016/j.ejmech.2017.09.060. Epub 2017 Sep 28. PMID:29028528
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Comment | 6-Azauridine, ribavirin, 2'-C-methyl-guanosin (NM108), efavirenz (EFV), pleconaril, acyclovir (ACG), and mycophenolic acid (M5255) were employed as reference inhibitors.
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