Chemical Information
Antiviral agent ID	DrugRepV_6041
Antiviral agent name	4-(3-Phenyl-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
IUPAC Name	4-[5-(2-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]benzene-1-sulfonamide
SMILES (canonical)	[H]N([H])S(=O)(=O)C1=CC=C(C=C1)N1N=C(CC1C1=CC=CC=C1C)C1=CC=CC=C1
Molecular Formula	C22H21N3O2S
Molecular Weight (g/mol)	391.49
InChl	InChI=1/C22H21N3O2S/c1-16-7-5-6-10-20(16)22-15-21(17-8-3-2-4-9-17)24-25(22)18-11-13-19(14-12-18)28(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
Structural Information
Clinical Information
Biological Information
Secondary Indication	Dengue virus (DENV) 2 Clinical isolate
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	BHK-21
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	0.01 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	>14 μM
Secondary Indication (Cell based assay)	MTT assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	EC50 [ 50 % ]
Secondary Indication (Cytotoxicity)	14 ± 0.001 μM
Reference	Fioravanti R, Desideri N, Carta A, Atzori EM, Delogu I, Collu G, Loddo R..Inhibitors of Yellow Fever Virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: Design, synthesis and antiviral evaluation..Eur J Med Chem. 2017 Dec 1;141:15-25. doi: 10.1016/j.ejmech.2017.09.060. Epub 2017 Sep 28. PMID:29028528
Comment	6-Azauridine, ribavirin, 2'-C-methyl-guanosin (NM108), efavirenz (EFV), pleconaril, acyclovir (ACG), and mycophenolic acid (M5255) were employed as reference inhibitors.