Chemical Information
Antiviral agent ID	DrugRepV_5987
Antiviral agent name	Castanospermine
IUPAC Name	(1S,6S,7R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,6,7,8-tetrol
SMILES (canonical)	C1CN2CC(C(C(C2C1O)O)O)O
SMILES (isomeric)	C1CN2C[C@@H]([C@H]([C@@H]([C@H]2[C@H]1O)O)O)O
Molecular Formula	C8H15NO4
Molecular Weight (g/mol)	189.211
InChl	InChI=1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4-,5-,6+,7+,8+/m0/s1
Common Name	Castanospermine
Synonyms	1,6,7,8-Tetrahydroxyoctahydroindolizine | (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine | Castinospermine | 6-Epicastanospermine
Structural Information
Clinical Information
Category	Antiviral
Primary Indication (Clinical trial phases)	Experimental
Biological Information
Primary Indication (Disease Category)	Infectious Disease
Primary Indication (Disease)	Dengue and Parainfluenza
Primary Indication (Drug target/Mode of Action)	Protein unc-93 homolog B1
Secondary Indication	Dengue virus (DENV) 2 16681-Replicon
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	in-vitro
Secondary Indication (Model system) [cell lines/ animal models]	BHK-21
Secondary Indication (Mode of viral infection)	Transfection
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection (24 hours)
Secondary Indication (Duration of drug delivery)	48 hours
Secondary Indication (Drug concentration)	15 μM
Secondary Indication (Cell based assay)	Renilla luciferase assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Luciferase Unit [ 20 NA ]
Reference	Whitby K, Pierson TC, Geiss B, Lane K, Engle M, Zhou Y, Doms RW, Diamond MS..Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo..J Virol. 2005 Jul;79(14):8698-706. PMID:15994763
Comment	Castanospermine has a strong antiviral effect on dengue virus infection and warrants further development as a possible treatment in humans.