Chemical Information
Antiviral agent ID	DrugRepV_5407
Antiviral agent name	Toremifene
IUPAC Name	2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
SMILES (canonical)	CN(C)CCOC1=CC=C(C=C1)C(=C(CCCl)C2=CC=CC=C2)C3=CC=CC=C3
SMILES (isomeric)	CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCl)\C2=CC=CC=C2)/C3=CC=CC=C3
Molecular Formula	C26H28ClNO
Molecular Weight (g/mol)	405.97
InChl	InChI=1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-
Common Name	Toremifene
Synonyms	Toremifeno | Toremifenum
Structural Information
Clinical Information
Category	Antineoplastic and Immunomodulating Agents
Primary Indication (Clinical trial phases)	Approved, Investigational
Biological Information
Primary Indication (Disease Category)	Non Infectious Disease
Primary Indication (Disease)	Breast Cancer
Secondary Indication	Lassa virus (LASV) NA Josiah
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	BSC-1
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection
Secondary Indication (Duration of drug delivery)	24 hours
Secondary Indication (Drug concentration)	2.88 μM
Secondary Indication (Cell based assay)	Luciferase assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	IC50 [ 50 % ]
Reference	Hulseberg CE, Feneant L, Szymanska-de Wijs KM, Kessler NP, Nelson EA, Shoemaker CJ, Schmaljohn CS, Polyak SJ, White JM..Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses..J Virol. 2019 Apr 3;93(8). pii: e02185-18. doi: 10.1128/JVI.02185-18. Print 2019 Apr 15. PubMed Cent PMID:30700611
Comment	Arbidol inhibits LASV fusion, which may partly involve blocking conformational changes in LASV GP.