Chemical Information
Antiviral agent ID	DrugRepV_5279
Antiviral agent name	1-[(2R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-imidazole-4,5-dicarbonitrile
IUPAC Name	1-[(2R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-imidazole-4,5-dicarbonitrile
SMILES (isomeric)	OC[C@@H]1O[C@H](C(O)C1O)N1C=NC(C#N)=C1C#N
Molecular Formula	C10H10N4O4
Molecular Weight (g/mol)	250.214
InChl	InChI=1/C10H10N4O4/c11-1-5-6(2-12)14(4-13-5)10-9(17)8(16)7(3-15)18-10/h4,7-10,15-17H,3H2/t7-,8?,9?,10+/s2
Structural Information
Clinical Information
Biological Information
Secondary Indication	Lassa virus (LASV) NA AV
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Vero
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	0.01 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection
Secondary Indication (Duration of drug delivery)	2 days
Secondary Indication (Drug concentration)	>50 μg/mL
Secondary Indication (Cell based assay)	Real-time PCR
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	IC50 [ 50 % ]
Secondary Indication (Cytotoxicity)	>50 μg/ml
Reference	Gunther S, Asper M, Roser C, Luna LK, Drosten C, Becker-Ziaja B, Borowski P, Chen HM, Hosmane RS..Application of real-time PCR for testing antiviral compounds against Lassa virus, SARS coronavirus a.Antiviral Res. 2004 Sep;63(3):209-15. PMID:15451189
Comment	Small-scale screening identified a class of imidazole nucleoside/nucleotide analogues with antiviral activity against Lassa virus. The analogues contained either dinitrile or diester groups at the imidazole 4,5-positions, and many of which possessed an acyclic sugar or sugar phosphonate moiety at the imidazole 1-position.