Chemical Information
Antiviral agent ID	DrugRepV_5259
Antiviral agent name	beta-D-cyclopentenyl-5-bromocytidine
IUPAC Name	4-amino-5-bromo-1-(3,4,5-trihydroxycyclopent-2-en-1-yl)-1,2-dihydropyrimidin-2-one
SMILES (canonical)	NC1=NC(=O)N(C=C1Br)C1C=C(O)C(O)C1O
Molecular Formula	C9H10BrN3O4
Molecular Weight (g/mol)	304.1
InChl	InChI=1/C9H10BrN3O4/c10-3-2-13(9(17)12-8(3)11)4-1-5(14)7(16)6(4)15/h1-2,4,6-7,14-16H,(H2,11,12,17)
Structural Information
Clinical Information
Biological Information
Secondary Indication	Variola virus (VARV) Major Bangladesh 1975
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	100 μg/mL
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	EC50 [ 50 % ]
Reference	Jin YH, Liu P, Wang J, Das U, Baker R, Huggins J, Chu CK..Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic.J Org Chem. 2003 Nov 14;68(23):9012-8. Erratum in: J Org Chem. 2005 Jan 7;70(1):394. PMID:14604375
Comment	Preliminary antiviral activity against orthopox viruses (smallpox, monkeypox, and cowpox virus) of the synthesized nucleosides are described.