DrugRepV|Encyclopedia for antivirals

Chemical, Structural, Clinical and Biological details of Antiviral agents ID: DrugRepV_5194

Chemical Information
Antiviral agent ID DrugRepV_5194
Antiviral agent name F694-1532
IUPAC Name N-[3-[(2-chloro-4-methylphenyl)carbamoylamino]-4-pyrrolidin-1-ylphenyl]-4-fluorobenzamide
SMILES (canonical) CC1=CC(=C(C=C1)NC(=O)NC2=C(C=CC(=C2)NC(=O)C3=CC=C(C=C3)F)N4CCCC4)Cl
Molecular Formula C25H24ClFN4O2
Molecular Weight (g/mol) 466.941

InChl InChI=1S/C25H24ClFN4O2/c1-16-4-10-21(20(26)14-16)29-25(33)30-22-15-19(9-11-23(22)31-12-2-3-13-31)28-24(32)17-5-7-18(27)8-6-17/h4-11,14-15H,2-3,12-13H2,1H3,(H,28,32)(H2,29,30,33)
Structural Information

Clinical Information
Biological Information
Secondary Indication Ebola virus (EBOV) NA Zaire
Secondary Indication (Approaches) Experimental
Secondary Indication (Methods) In-vitro
Secondary Indication (Model system) [cell lines/ animal models] Hela
Secondary Indication (Mode of viral infection) Adsorption
Secondary Indication (Viral titer) 3 MOI
Secondary Indication (Mode of drug delivery) Culture
Secondary Indication (Time of drug delivery) Pre infection (2 hours)
Secondary Indication (Duration of drug delivery) 48 hours
Secondary Indication (Drug concentration) 117.6 μM
Secondary Indication (Cell based assay) Immunoflourescence assay
Secondary Indication (Change) Decrease
Secondary Indication (Type of Inhibition) EC50 [ 50 % ]
Reference Mudhasani R, Kota KP, Retterer C, Tran JP, Whitehouse CA, Bavari S..High content image-based screening of a protease inhibitor library reveals compounds broadly active.PLoS Negl Trop Dis. 2014 Aug 21;8(8):e3095. doi: 10.1371/journal.pntd.0003095. eCollection 2014 Aug. PMID:25144302
Comment G202-0362 and C795-0925 did not alter any morphological features and may prove to be good candidates for antiviral drug development. Overall this work demonstrates that high-content image analysis can be used to screen chemical libraries for new antivirals and also to determine their mechanism of action.

Copyright © 2019. CSIR-Institute of Microbial Technology, Chandigarh, INDIA.

Chemical Information
Antiviral agent ID	DrugRepV_5194
Antiviral agent name	F694-1532
IUPAC Name	N-[3-[(2-chloro-4-methylphenyl)carbamoylamino]-4-pyrrolidin-1-ylphenyl]-4-fluorobenzamide
SMILES (canonical)	CC1=CC(=C(C=C1)NC(=O)NC2=C(C=CC(=C2)NC(=O)C3=CC=C(C=C3)F)N4CCCC4)Cl
Molecular Formula	C25H24ClFN4O2
Molecular Weight (g/mol)	466.941
InChl	InChI=1S/C25H24ClFN4O2/c1-16-4-10-21(20(26)14-16)29-25(33)30-22-15-19(9-11-23(22)31-12-2-3-13-31)28-24(32)17-5-7-18(27)8-6-17/h4-11,14-15H,2-3,12-13H2,1H3,(H,28,32)(H2,29,30,33)
Structural Information

Clinical Information
Biological Information
Secondary Indication	Ebola virus (EBOV) NA Zaire
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Hela
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	3 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Pre infection (2 hours)
Secondary Indication (Duration of drug delivery)	48 hours
Secondary Indication (Drug concentration)	117.6 μM
Secondary Indication (Cell based assay)	Immunoflourescence assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	EC50 [ 50 % ]
Reference	Mudhasani R, Kota KP, Retterer C, Tran JP, Whitehouse CA, Bavari S..High content image-based screening of a protease inhibitor library reveals compounds broadly active.PLoS Negl Trop Dis. 2014 Aug 21;8(8):e3095. doi: 10.1371/journal.pntd.0003095. eCollection 2014 Aug. PMID:25144302
Comment	G202-0362 and C795-0925 did not alter any morphological features and may prove to be good candidates for antiviral drug development. Overall this work demonstrates that high-content image analysis can be used to screen chemical libraries for new antivirals and also to determine their mechanism of action.