Chemical Information
Antiviral agent ID	DrugRepV_5089
Antiviral agent name	S-Nitroso-N-acetylpenicillamine
IUPAC Name	(2~{R})-2-acetamido-3-methyl-3-nitrososulfanylbutanoic acid
SMILES (canonical)	CC(=O)NC(C(=O)O)C(C)(C)SN=O
SMILES (isomeric)	CC(=O)N[C@H](C(=O)O)C(C)(C)SN=O
Molecular Formula	C7H12N2O4S
Molecular Weight (g/mol)	220.243
InChl	InChI=1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)/t5-/m1/s1
Synonyms	N-Acetyl-3-(nitrosothio)-valine | N-acetyl-3-(nitrosothio)-D-Valine | s-nitroso-l-acetyl penicillamine
Structural Information
Clinical Information
Biological Information
Secondary Indication	Crimean-Congo hemorrhagic fever virus (CCHFV) NA IbAr 10200
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	VeroE6
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	0.03 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Pre infection (3 or 6 hours)
Secondary Indication (Duration of drug delivery)	24 hours
Secondary Indication (Drug concentration)	400 μM
Secondary Indication (Cell based assay)	Immunoflourescence assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Percentage inhibition [ >90 % ]
Reference	Simon M, Falk KI, Lundkvist A, Mirazimi A..Exogenous nitric oxide inhibits Crimean Congo hemorrhagic fever virus..Virus Res. 2006 Sep;120(1-2):184-90. Epub 2006 May 2. PMID:16632039
Comment	The expression of viral proteins; the nucleocapsid protein and the glycoprotein, were reduced with increasing concentrations of SNAP.