Chemical Information
Antiviral agent ID	DrugRepV_4598
Antiviral agent name	7-[(3-chlorophenyl)methoxy]-8-hydroxy-3-[(3-iodophenyl)methoxy]-1,4-dihydronaphthalen-1-one
IUPAC Name	7-[(3-chlorophenyl)methoxy]-8-hydroxy-3-[(3-iodophenyl)methoxy]-1,4-dihydronaphthalen-1-one
SMILES (canonical)	OC1=C(OCC2=CC(Cl)=CC=C2)C=CC2=C1C(=O)C=C(C2)OCC1=CC(I)=CC=C1
Molecular Formula	C24H18ClIO4
Molecular Weight (g/mol)	532.76
InChl	InChI=1S/C24H18ClIO4/c25-18-5-1-3-15(9-18)14-30-22-8-7-17-11-20(12-21(27)23(17)24(22)28)29-13-16-4-2-6-19(26)10-16/h1-10,12,28H,11,13-14H2
Structural Information
Clinical Information
Biological Information
Secondary Indication	Severe acute respiratory syndrome coronavirus (SARS-CoV) NA NA
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Huh-7
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection
Secondary Indication (Duration of drug delivery)	24 hours
Secondary Indication (Drug concentration)	23 μM
Secondary Indication (Cell based assay)	Luciferase assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	IC50 [ 50 % ]
Secondary Indication (Cytotoxicity)	>50 μM
Reference	Kim MK, Yu MS, Park HR, Kim KB, Lee C, Cho SY, Kang J, Yoon H, Kim DE, Choo H, Jeong YJ, Chong Y..2,6-Bis-arylmethyloxy-5-hydroxychromones with antiviral activity against both hepatitis C virus (HCV) and SARS-associated coronavirus (SCV)..Eur J Med Chem. 2011 Nov;46(11):5698-704. doi: 10.1016/j.ejmech.2011.09.005. Epub 2011 Sep 8. PMID:21925774
Comment	NA