Chemical Information
Antiviral agent ID	DrugRepV_4396
Antiviral agent name	N-(aminocarbonyl)-2-{[(5-methyl-3-thienyl)carbonyl]amino}-3-thiophenecarboxamide
IUPAC Name	N-(aminocarbonyl)-2-{[(5-methyl-3-thienyl)carbonyl]amino}-3-thiophenecarboxamide
SMILES (canonical)	CC1=CC(=CS1)C(=O)NC2=C(C=CS2)C(=O)NC(=O)N
Molecular Formula	C12H11N3O3S2
Molecular Weight (g/mol)	309.4
InChl	InChI=1S/C12H11N3O3S2/c1-6-4-7(5-20-6)9(16)14-11-8(2-3-19-11)10(17)15-12(13)18/h2-5H,1H3,(H,14,16)(H3,13,15,17,18)
Structural Information
Clinical Information
Biological Information
Secondary Indication	Hendra virus (HeV) NA F0, amino acids 105 to 114
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	293FT
Secondary Indication (Viral titer)	1 μM
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	40 μM
Secondary Indication (Cell based assay)	CatL-Peptide cleavage
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Percentage inhibition [ 37.33 % ]
Reference	Elshabrawy HA, Fan J, Haddad CS, Ratia K, Broder CC, Caffrey M, Prabhakar BS..Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay..J Virol. 2014 Apr;88(8):4353-65. doi: 10.1128/JVI.03050-13. Epub 2014 Feb 5. PubMed Central PMCID: P PMID:24501399
Comment	A novel broad-spectrum small molecule that could block cathepsin L-mediated cleavage was identified and thus inhibit the entry of pseudotypes bearing the glycoprotein derived from SARS-CoV or Ebola, Hendra, or Nipah virus. The small molecule can be further optimized and developed into a potent broad-spectrum antiviral drug.