Chemical Information | |
Antiviral agent ID | DrugRepV_4329 | |
Antiviral agent name | 2-[(1H-benzimidazol-2-ylmethyl)thio]-1-[2-(4-methylphenoxy)ethyl]-1H-benzimidazole | |
IUPAC Name | 2-[(1H-benzimidazol-2-ylmethyl)thio]-1-[2-(4-methylphenoxy)ethyl]-1H-benzimidazole | |
SMILES (canonical) | CC1=CC=C(C=C1)OCCN2C3=CC=CC=C3N=C2SCC4=NC5=CC=CC=C5N4 | |
Molecular Formula | C24H22N4OS | |
Molecular Weight (g/mol) | 414.5 | |
InChl | InChI=1S/C24H22N4OS/c1-17-10-12-18(13-11-17)29-15-14-28-22-9-5-4-8-21(22)27-24(28)30-16-23-25-19-6-2-3-7-20(19)26-23/h2-13H,14-16H2,1H3,(H,25,26) | |
Structural Information | |
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Clinical Information | |
Biological Information | |
Secondary Indication | Ebola virus (EBOV) NA GP, amino acids 196 to 205 | |
Secondary Indication (Approaches) | Experimental | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | 293FT
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Secondary Indication (Viral titer) | 1 μM
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Drug concentration) | 40 μM
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Secondary Indication (Cell based assay) | CatL-Peptide cleavage
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Secondary Indication (Change) | Decrease
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Secondary Indication (Type of Inhibition) | Percentage inhibition [ -1.8 % ] | |
Reference | Elshabrawy HA, Fan J, Haddad CS, Ratia K, Broder CC, Caffrey M, Prabhakar BS..Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay..J Virol. 2014 Apr;88(8):4353-65. doi: 10.1128/JVI.03050-13. Epub 2014 Feb 5. PubMed Central PMCID: P PMID:24501399
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Comment | A novel broad-spectrum small molecule that could block cathepsin L-mediated cleavage was identified and thus inhibit the entry of pseudotypes bearing the glycoprotein derived from SARS-CoV or Ebola, Hendra, or Nipah virus. The small molecule can be further optimized and developed into a potent broad-spectrum antiviral drug.
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