Chemical Information
Antiviral agent ID	DrugRepV_4122
Antiviral agent name	Coumarin B
IUPAC Name	7-[(1E)-3-methylbuta-1,3-dienoxy]chromen-2-one
SMILES (canonical)	CC(=C)C=COC1=CC2=C(C=C1)C=CC(=O)O2
SMILES (isomeric)	CC(=C)/C=C/OC1=CC2=C(C=C1)C=CC(=O)O2
Molecular Formula	C14H12O3
Molecular Weight (g/mol)	228.247
InChl	InChI=1S/C14H12O3/c1-10(2)7-8-16-12-5-3-11-4-6-14(15)17-13(11)9-12/h3-9H,1H2,2H3/b8-7+
Structural Information
Clinical Information
Biological Information
Secondary Indication	Chikungunya virus (CHIKV) NA Acol
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Vero
Secondary Indication (Viral titer)	0.1 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	200 μg/ml
Secondary Indication (Cell based assay)	Plating method
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Percentage Inhibition [ 92.5 % ]
Reference	Gomez-Calderon C, Mesa-Castro C, Robledo S, Gomez S, Bolivar-Avila S, Diaz-Castillo F, Martinez-Gutierrez M..Antiviral effect of compounds derived from the seeds of Mammea americana and Tabernaemontana cymosa on Dengue and Chikungunya virus infections..BMC Complement Altern Med. 2017 Jan 18;17(1):57. doi: 10.1186/s12906-017-1562-1. PubMed Central PMCI PMID:28100218
Comment	Subsequent studies with in vivo models help to elucidate the antiviral mechanism induced by these two compounds as well as other possible effects beyond that of the antivirals that can help improve the pathogenesis of dengue and chikungunya.