Chemical Information
Antiviral agent ID	DrugRepV_3921
Antiviral agent name	cp19
IUPAC Name	1-{3-[(3-benzyl-4-methyl-2-oxo-2H-chromen-7-yl)oxy]-2-hydroxypropyl}piperidine-4-carboxamide
SMILES (canonical)	CC1=C(CC2=CC=CC=C2)C(=O)OC2=CC(OCC(O)CN3CCC(CC3)C(N)=O)=CC=C12
Molecular Formula	C26H30N2O5
Molecular Weight (g/mol)	450.535
InChl	InChI=1/C26H30N2O5/c1-17-22-8-7-21(32-16-20(29)15-28-11-9-19(10-12-28)25(27)30)14-24(22)33-26(31)23(17)13-18-5-3-2-4-6-18/h2-8,14,19-20,29H,9-13,15-16H2,1H3,(H2,27,30)
Structural Information
Clinical Information
Biological Information
Secondary Indication	Ebola virus (EBOV) NA Kikwit
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	A549
Secondary Indication (Mode of viral infection)	Transfection
Secondary Indication (Viral titer)	2 PFU/cell
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Pre infection
Secondary Indication (Duration of drug delivery)	48 hours
Secondary Indication (Drug concentration)	3.7 ± 1.5 μM
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	IC50 [ 50 % ]
Secondary Indication (Cytotoxicity)	71 μM
Reference	Cheng H, Schafer A, Soloveva V, Gharaibeh D, Kenny T, Retterer C, Zamani R, Bavari S, Peet NP, Rong L..Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor..Antiviral Res. 2017 Sep;145:24-32. doi: 10.1016/j.antiviral.2017.06.015. Epub 2017 Jun 20. PubMed Ce PMID:28645623
Comment	1220 small molecules with predicted antihistamine activity were screened that identify multiple compounds with potent inhibitory activity against entry of both Ebola and Marburg viruses in human cancer cell lines, and confirmed their anti-Ebola activity in human primary cells.