Chemical Information
Antiviral agent ID	DrugRepV_3810
Antiviral agent name	MLS000583959
IUPAC Name	2-(N-(2-chloroacetyl)-4-methylanilino)-N-cyclohexyl-2-(4-methoxyphenyl)acetamide
SMILES (canonical)	CC1=CC=C(C=C1)N(C(C2=CC=C(C=C2)OC)C(=O)NC3CCCCC3)C(=O)CCl
Molecular Formula	C24H29ClN2O3
Molecular Weight (g/mol)	428.957
InChl	InChI=1S/C24H29ClN2O3/c1-17-8-12-20(13-9-17)27(22(28)16-25)23(18-10-14-21(30-2)15-11-18)24(29)26-19-6-4-3-5-7-19/h8-15,19,23H,3-7,16H2,1-2H3,(H,26,29)
Synonyms	AC1N680C | SMR000206945 | AKOS024440146
Structural Information
Clinical Information
Biological Information
Secondary Indication	Ebola virus (EBOV) NA Mayinga
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	HeLa
Secondary Indication (Viral titer)	0.075 to 0.15 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Duration of drug delivery)	24 hours
Secondary Indication (Drug concentration)	12.4 μM
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	IC50 [ 50 % ]
Reference	Anantpadma M, Kouznetsova J, Wang H, Huang R, Kolokoltsov A, Guha R, Lindstrom AR, Shtanko O, Simeonov A, Maloney DJ, Maury W, LaCount DJ, Jadhav A, Davey RA..Large-Scale Screening and Identification of Novel Ebola Virus and Marburg Virus Entry Inhibitors..Antimicrob Agents Chemother. 2016 Jul 22;60(8):4471-81. doi: 10.1128/AAC.00543-16. Print 2016 Aug. P PMID:27161622
Comment	Each compound blocked infection of primary human macrophages, indicating their potential to be developed as new antifiloviral therapies.