Chemical Information | |
Antiviral agent ID | DrugRepV_3791 | |
Antiviral agent name | MLS000106706 | |
IUPAC Name | 2-[5-(4-chloro-3,5-dimethylphenoxy)pentylamino]ethanol | |
SMILES (canonical) | CC1=CC(=CC(=C1Cl)C)OCCCCCNCCO | |
Molecular Formula | C15H24ClNO2 | |
Molecular Weight (g/mol) | 285.812 | |
InChl | InChI=1S/C15H24ClNO2/c1-12-10-14(11-13(2)15(12)16)19-9-5-3-4-6-17-7-8-18/h10-11,17-18H,3-9H2,1-2H3 | |
Synonyms | AC1M43CL | REGID_for_CID_2250138 | HMS2465L21 | |
Structural Information | |
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Clinical Information | |
Biological Information | |
Secondary Indication | Marburg virus (MARV) NA Musoke | |
Secondary Indication (Approaches) | Experimental | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | HeLa
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Secondary Indication (Viral titer) | 0.075 to 0.15 MOI
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Duration of drug delivery) | 24 hours
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Secondary Indication (Drug concentration) | 25.24 μM
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Secondary Indication (Change) | Decrease
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Secondary Indication (Type of Inhibition) | IC50 [ 50 % ] | |
Reference | Anantpadma M, Kouznetsova J, Wang H, Huang R, Kolokoltsov A, Guha R, Lindstrom AR, Shtanko O, Simeonov A, Maloney DJ, Maury W, LaCount DJ, Jadhav A, Davey RA..Large-Scale Screening and Identification of Novel Ebola Virus and Marburg Virus Entry Inhibitors..Antimicrob Agents Chemother. 2016 Jul 22;60(8):4471-81. doi: 10.1128/AAC.00543-16. Print 2016 Aug. P PMID:27161622
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Comment | Each compound blocked infection of primary human macrophages, indicating their potential to be developed as new antifiloviral therapies.
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