Chemical Information | |
Antiviral agent ID | DrugRepV_3777 | |
Antiviral agent name | MLS001173370 | |
IUPAC Name | 1-(4-fluorophenyl)-4-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)butan-1-one | |
SMILES (canonical) | C1CN(CC2=C1NC3=C2C=C(C=C3)F)CCCC(=O)C4=CC=C(C=C4)F | |
Molecular Formula | C21H20F2N2O | |
Molecular Weight (g/mol) | 354.401 | |
InChl | InChI=1S/C21H20F2N2O/c22-15-5-3-14(4-6-15)21(26)2-1-10-25-11-9-20-18(13-25)17-12-16(23)7-8-19(17)24-20/h3-8,12,24H,1-2,9-11,13H2 | |
Synonyms | SMR000538911 | AC1L1UJA | AC1Q4NJ8 | |
Structural Information | |
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Clinical Information | |
Biological Information | |
Secondary Indication | Marburg virus (MARV) NA Musoke | |
Secondary Indication (Approaches) | Experimental | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | HeLa
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Secondary Indication (Viral titer) | 0.075 to 0.15 MOI
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Duration of drug delivery) | 24 hours
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Secondary Indication (Drug concentration) | 25.14 μM
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Secondary Indication (Change) | Decrease
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Secondary Indication (Type of Inhibition) | IC50 [ 50 % ] | |
Reference | Anantpadma M, Kouznetsova J, Wang H, Huang R, Kolokoltsov A, Guha R, Lindstrom AR, Shtanko O, Simeonov A, Maloney DJ, Maury W, LaCount DJ, Jadhav A, Davey RA..Large-Scale Screening and Identification of Novel Ebola Virus and Marburg Virus Entry Inhibitors..Antimicrob Agents Chemother. 2016 Jul 22;60(8):4471-81. doi: 10.1128/AAC.00543-16. Print 2016 Aug. P PMID:27161622
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Comment | Each compound blocked infection of primary human macrophages, indicating their potential to be developed as new antifiloviral therapies.
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