Chemical Information
Antiviral agent ID	DrugRepV_3736
Antiviral agent name	OSU-03012
IUPAC Name	2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide
SMILES (canonical)	C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F
Molecular Formula	C26H19F3N4O
Molecular Weight (g/mol)	460.46
InChl	InChI=1S/C26H19F3N4O/c27-26(28,29)24-14-23(33(32-24)20-10-8-19(9-11-20)31-25(34)15-30)18-7-12-22-17(13-18)6-5-16-3-1-2-4-21(16)22/h1-14H,15,30H2,(H,31,34)
Synonyms	N-(4-(5-(2-Phenanthryl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)ethane-1,2-diamine | PDK1 inhibitor AR-12 | DTXSID50225206
Structural Information
Clinical Information
Category	Anticancer
Biological Information
Primary Indication (Disease Category)	Non Infectious Disease
Primary Indication (Disease)	Brain cancer
Secondary Indication	Marburg virus (MARV) NA NA
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Huh-7
Secondary Indication (Viral titer)	0.2 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	During infection
Secondary Indication (Duration of drug delivery)	48 hours
Secondary Indication (Drug concentration)	0.3 ± 0.1 μM
Secondary Indication (Cell based assay)	GFP assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	EC50 [ 50 % ]
Secondary Indication (Cytotoxicity)	7.1 ± 0.6 μM
Reference	Mohr EL, McMullan LK, Lo MK, Spengler JR, Bergeron E, Albarino CG, Shrivastava-Ranjan P, Chiang CF, Nichol ST, Spiropoulou CF, Flint M..Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses..Antiviral Res. 2015 Aug;120:40-7. doi: 10.1016/j.antiviral.2015.05.003. Epub 2015 May 16. PMID:25986249
Comment	BIBX 1382 is an inhibitor of LASV and EBOV entry. OSU-03012 reduces LASV and EBOV virus titers and RNA levels, but does not inhibit entry or LASV Z-protein mediated assembly.