Chemical Information
Antiviral agent ID	DrugRepV_3678
Antiviral agent name	NSC 62914
IUPAC Name	2,6-bis[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
SMILES (canonical)	CC1=CC(=C(C(=C1)CC2=C(C(=CC(=C2)C)C(C)(C)C)O)O)CC3=C(C(=CC(=C3)C)C(C)(C)C)O
Molecular Formula	C31H40O3
Molecular Weight (g/mol)	460.658
InChl	InChI=1S/C31H40O3/c1-18-10-21(16-23-12-19(2)14-25(28(23)33)30(4,5)6)27(32)22(11-18)17-24-13-20(3)15-26(29(24)34)31(7,8)9/h10-15,32-34H,16-17H2,1-9H3
Structural Information
Clinical Information
Biological Information
Secondary Indication	Rift Valley fever virus (RVFV) NA MP12
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	A549
Secondary Indication (Viral titer)	1 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	20 μM
Secondary Indication (Cell based assay)	RT-PCR
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Percentage viral inhibition [ 97 % ]
Reference	Panchal RG, Reid SP, Tran JP, Bergeron AA, Wells J, Kota KP, Aman J, Bavari S..Identification of an Antioxidant small-molecule with broad-spectrum antiviral activity..Antiviral Res. 2012 Jan;93(1):23-9. doi: 10.1016/j.antiviral.2011.10.011. Epub 2011 Oct 18. PMID:22027648
Comment	Compound NSC 62914 was found to act as a scavenger of reactive oxygen species, and to up-regulate oxidative stress-induced genes.