Chemical Information
Antiviral agent ID	DrugRepV_3651
Antiviral agent name	2-phenyl-4-(1,1,2,2-tetrafluoroethyl)-3H-1,5-benzodiazepine
IUPAC Name	2-phenyl-4-(1,1,2,2-tetrafluoroethyl)-3H-1,5-benzodiazepine
SMILES (canonical)	FC(F)C(F)(F)C1=NC2=C(C=CC=C2)N=C(C1)C1=CC=CC=C1
Molecular Formula	C17H12F4N2
Molecular Weight (g/mol)	320.291
InChl	InChI=1S/C17H12F4N2/c18-16(19)17(20,21)15-10-14(11-6-2-1-3-7-11)22-12-8-4-5-9-13(12)23-15/h1-9,16H,10H2
Structural Information
Clinical Information
Biological Information
Secondary Indication	Severe acute respiratory syndrome coronavirus (SARS- CoV) NA Urbani
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Vero76
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	>36 μM
Secondary Indication (Cell based assay)	Luciferase assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	IC50 [ 50 % ]
Secondary Indication (Cytotoxicity)	36 μM
Reference	Basu A, Li B, Mills DM, Panchal RG, Cardinale SC, Butler MM, Peet NP, Majgier-Baranowska H, Williams JD, Patel I, Moir DT, Bavari S, Ray R, Farzan MR, Rong L, Bowlin TL..Identification of a small-molecule entry inhibitor for filoviruses..J Virol. 2011 Apr;85(7):3106-19. doi: 10.1128/JVI.01456-10. Epub 2011 Jan 26. PubMed Central PMCID: PMID:21270170
Comment	A benzodiazepine derivative (compound 7) was identified from a high-throughput screen (HTS) of small-molecule compound libraries utilizing the pseudotype virus.