Chemical Information
Antiviral agent ID	DrugRepV_3371
Antiviral agent name	Mercaptopurine
IUPAC Name	3,7-dihydropurine-6-thione
SMILES (canonical)	C1=NC2=C(N1)C(=S)N=CN2
Molecular Formula	C5H4N4S
Molecular Weight (g/mol)	152.175
InChl	InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
Common Name	Mercaptopurine
Synonyms	6 MP | 6-Mercaptopurine | 6-MP | 6-Thiohypoxanthine | 6-Thioxopurine | Mercaptopurina | Mercaptopurine anhydrous | mercaptopurinum | Mercapurin
Structural Information
Clinical Information
Category	Antineoplastic and Immunomodulating Agents
Primary Indication (Clinical trial phases)	Approved
Biological Information
Primary Indication (Disease Category)	Non Infectious Disease
Primary Indication (Disease)	Acute lymphatic leukemia
Secondary Indication	Influenza virus (IAV) H1N1 A/ WSN/1933 (H1N1)
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	MDCK
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	0.01 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	26.5 μM
Secondary Indication (Cell based assay)	High-throughput screening
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	EC50 [ 50 % ]
Secondary Indication (Cytotoxicity)	100 μM
Reference	Chan JF, Chan KH, Kao RY, To KK, Zheng BJ, Li CP, Li PT, Dai J, Mok FK, Chen H, Hayden FG, Yuen KY..Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus..J Infect. 2013 Dec;67(6):606-16. doi: 10.1016/j.jinf.2013.09.029. Epub 2013 Oct 3. PMID:24096239
Comment	Mycophenolic acid exhibited low EC50 and high selectivity index. Additionally, ribavirin and interferons also exhibited in-vitro anti-MERS-CoV activity