Chemical Information
Antiviral agent ID	DrugRepV_3250
Antiviral agent name	T-1105
IUPAC Name	2-oxo-1H-pyrazine-3-carboxamide
SMILES (canonical)	C1=CN=C(C(=O)N1)C(=O)N
Molecular Formula	C5H5N3O2
Molecular Weight (g/mol)	139.114
InChl	InChI=1S/C5H5N3O2/c6-4(9)3-5(10)8-2-1-7-3/h1-2H,(H2,6,9)(H,8,10)
Synonyms	2-oxo-1H-pyrazine-3-carboxamide | 3-Oxo-3,4-dihydropyrazine-2-carboxamide | Pyrazinecarboxamide, 3,4-dihydro-3-oxo- | 55321-99-8 | Pyrazine-2-carboxamide, 3-hydroxy- | 3-Hydroxy-2-pyrazinecarboxamide
Structural Information
Clinical Information
Biological Information
Primary Indication (Disease Category)	Infectious Disease
Primary Indication (Disease)	Zika virus
Secondary Indication	Chikungunya virus (CHIKV) NA LR2006 OPY1
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Vero
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	0.01 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection
Secondary Indication (Duration of drug delivery)	7 days
Secondary Indication (Drug concentration)	7.3 ± 0.8 μM
Secondary Indication (Cell based assay)	Real-time PCR
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	EC50 [ 50 % ]
Reference	Delang L, Segura Guerrero N, Tas A, QuÌÄå©rat G, Pastorino B, Froeyen M, Dallmeier K, Jochmans D, Herd.Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705),.J Antimicrob Chemother. 2014 Oct;69(10):2770-84. doi: 10.1093/jac/dku209. Epub 2014 Jun 20. PMID:24951535
Comment	Favipiravir exerts broad-spectrum anti-alphavirus activity and provides protection in a mouse model of lethal CHIKV infection.