Chemical Information | |
Antiviral agent ID | DrugRepV_3197 | |
Antiviral agent name | Arbidol | |
IUPAC Name | ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | |
SMILES (canonical) | CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3 | |
Molecular Formula | C22H25BrN2O3S | |
Molecular Weight (g/mol) | 477.417 | |
InChl | InChI=1S/C22H25BrN2O3S/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3/h6-11,26H,5,12-13H2,1-4H3 | |
Common Name | Umifenovir | |
Structural Information | |
|
|
Clinical Information | |
Primary Indication (Clinical trial phases) | Investigational
| |
Biological Information | |
Primary Indication (Disease Category) | Infectious Disease
| |
Primary Indication (Disease) | Viral infection
| |
Secondary Indication | Influenza virus (IAV) H3N2 A/Aichi/2/68 | |
Secondary Indication (Approaches) | Experimental | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | MDCK
| |
Secondary Indication (Mode of viral infection) | Adsorption
| |
Secondary Indication (Mode of drug delivery) | Culture
| |
Secondary Indication (Time of drug delivery) | Post infection
| |
Secondary Indication (Duration of drug delivery) | 48 hours
| |
Secondary Indication (Drug concentration) | 7.5 μg/ml
| |
Secondary Indication (Cell based assay) | Plaque assay
| |
Secondary Indication (Change) | Decrease
| |
Secondary Indication (Type of Inhibition) | Log reduction [ 2.5 log ] | |
Reference | Brooks MJ, Burtseva EI, Ellery PJ, Marsh GA, Lew AM, Slepushkin AN, Crowe SM, Tannock GA..Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies acc.J Med Virol. 2012 Jan;84(1):170-81. doi: 10.1002/jmv.22234. Epub 2011 Oct 25. PMID:22028179
| |
Comment | Arbidol as a broad spectrum respiratory antiviral drug
| |