Chemical Information
Antiviral agent ID	DrugRepV_3124
Antiviral agent name	Rottlerin
IUPAC Name	(E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one
SMILES (canonical)	CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)C=CC4=CC=CC=C4)OC(C=C3)(C)C)O)O
SMILES (isomeric)	CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)/C=C/C4=CC=CC=C4)OC(C=C3)(C)C)O)O
Molecular Formula	C30H28O8
Molecular Weight (g/mol)	516.546
InChl	InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
Structural Information
Clinical Information
Biological Information
Secondary Indication	Chikungunya virus (CHIKV) NA CHIKV-0708
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	BHK-21
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	1 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection
Secondary Indication (Duration of drug delivery)	24 hours
Secondary Indication (Drug concentration)	10 μM
Secondary Indication (Cell based assay)	Immunoflourescence assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Percentage inhibition [ 92.81 % ]
Reference	Kaur P, Thiruchelvan M, Lee RC, Chen H, Chen KC, Ng ML, Chu JJ..Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses vira.Antimicrob Agents Chemother. 2013 Jan;57(1):155-67. doi: 10.1128/AAC.01467-12. Epub 2012 Oct 22. PMID:23275491
Comment	Harringtonine inhibited an early stage of chikungunya virus replication which occurred after viral entry into cell. Its affects CHIKV RNA production as well as viral protein expression. Harringtonine also inhibited Sindbis virus replication.