Chemical Information
Antiviral agent ID	DrugRepV_2996
Antiviral agent name	Flavaglines FL3
IUPAC Name	(1R,3S,3aR,8bS)-3a-(4-Bromophenyl)-6,8-dimethoxy-3-phenyl-1,2,3,3a-tetrahydro-8bH-benzo[b]cyclopenta[d]furan-1,8b-diol
SMILES (isomeric)	COc1cc2c(c(c1)OC)[C@@]3([C@@H](C[C@H]([C@@]3(O2)c4ccc(cc4)Br)c5ccccc5)O)O
Molecular Formula	C25H23BrO5
Molecular Weight (g/mol)	483.351
InChl	InChI=1S/C25H23BrO5/c1-29-18-12-20(30-2)23-21(13-18)31-25(16-8-10-17(26)11-9-16)19(14-22(27)24(23,25)28)15-6-4-3-5-7-15/h3-13,19,22,27-28H,14H2,1-2H3/t19-,22+,24+,25-/m0/s1
Structural Information
Clinical Information
Category	Anticancer
Biological Information
Secondary Indication	Chikungunya virus (CHIKV) NA NA
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	HEK-293T/17
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	10 PFU/cell
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Pre infection (1 hour)
Secondary Indication (Duration of drug delivery)	20 hours
Secondary Indication (Drug concentration)	20 nM
Secondary Indication (Cell based assay)	Plaque assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Percentage inhibition [ 50 % ]
Reference	Wintachai P, Thuaud F, Basmadjian C, Roytrakul S, Ubol S, DÌÄå©saubry L, Smith DR..Assessment of flavaglines as potential chikungunya virus entry inhibitors..Microbiol Immunol. 2015 Mar;59(3):129-41. doi: 10.1111/1348-0421.12230. PMID:25643977
Comment	Synthetic sulfonyl amidines and flavaglines (FLs), a class of naturally occurring plant compounds with potent anti-cancer and cytoprotective and neuroprotective activities, have been shown to interact directly with prohibitin.