| Chemical Information | |
| Antiviral agent ID | DrugRepV_2566 | |
| Antiviral agent name | Lincomycin Hydrochloride |  |
| IUPAC Name | (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride |  |
| SMILES (canonical) | CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O.Cl | |
| SMILES (isomeric) | CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O.Cl | |
| Molecular Formula | C18H35ClN2O6S | |
| Molecular Weight (g/mol) | 442.996 | |
| InChl | InChI=1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1 | |
| Common Name | Lincomycin | |
| Synonyms | LCM | Lincomycine | |
| Structural Information | |
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| Clinical Information | |
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Category | Antiinfectives For Systemic Use
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Primary Indication (Clinical trial phases) | Approved, Vet approved
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| Biological Information | |
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Primary Indication (Disease Category) | Infectious Disease
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Primary Indication (Disease) | Bacterial infections
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Primary Indication (Drug target/Mode of Action) | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
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Secondary Indication | Chikungunya virus (CHIKV) NA vAc-CHIKV 26S-Rhir-E |   |
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Secondary Indication (Approaches) | Experimental | |
| Secondary Indication (Methods) | in-vitro | |
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Secondary Indication (Model system) [cell lines/ animal models] | Sf21
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Secondary Indication (Mode of viral infection) | Adsorption
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Secondary Indication (Viral titer) | 2 MOI
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Drug concentration) | 100 μM
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Secondary Indication (Cell based assay) | Fusion index-Fluorescent Intensities
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Secondary Indication (Change) | Increase
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Secondary Indication (Type of Inhibition) | Percentage inhibition [ -1.1874718 % ] | |
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Reference | Wang YM, Lu JW, Lin CC, Chin YF, Wu TY, Lin LI, Lai ZZ, Kuo SC, Ho YJ..Antiviral activities of niclosamide and nitazoxanide against chikungunya virus entry and transmissio.Antiviral Res. 2016 Nov;135:81-90. doi: 10.1016/j.antiviral.2016.10.003. Epub 2016 Oct 11. PMID:27742486
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Comment | Niclosamide and nitazoxanide were able to inhibit CHIKV entry and transmission, which might provide a basis for the development of novel human drug therapies against CHIKV and other alphavirus infections.
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