Chemical Information
Antiviral agent ID	DrugRepV_2469
Antiviral agent name	Milrinone
IUPAC Name	6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
SMILES (canonical)	CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
Molecular Formula	C12H9N3O
Molecular Weight (g/mol)	211.224
InChl	InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
Common Name	Milrinone
Synonyms	1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile | Milrinona | Milrinone | Milrinonum
Structural Information
Clinical Information
Category	Cardiovascular agents
Primary Indication (Clinical trial phases)	Approved
Biological Information
Primary Indication (Disease Category)	Non Infectious Disease
Primary Indication (Disease)	Cardiotonic agent
Secondary Indication	Chikungunya virus (CHIKV) NA vAc-CHIKV 26S-Rhir-E
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	in-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Sf21
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	2 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	100 μM
Secondary Indication (Cell based assay)	Fusion index-Fluorescent Intensities
Secondary Indication (Change)	No significant decrease
Secondary Indication (Type of Inhibition)	Percentage inhibition [ 0.70603205 % ]
Reference	Wang YM, Lu JW, Lin CC, Chin YF, Wu TY, Lin LI, Lai ZZ, Kuo SC, Ho YJ..Antiviral activities of niclosamide and nitazoxanide against chikungunya virus entry and transmissio.Antiviral Res. 2016 Nov;135:81-90. doi: 10.1016/j.antiviral.2016.10.003. Epub 2016 Oct 11. PMID:27742486
Comment	Niclosamide and nitazoxanide were able to inhibit CHIKV entry and transmission, which might provide a basis for the development of novel human drug therapies against CHIKV and other alphavirus infections.