Chemical Information
Antiviral agent ID	DrugRepV_2136
Antiviral agent name	7-deaza-2-C-methyl-D-adenosine
IUPAC Name	(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
SMILES (canonical)	CC1(C(C(OC1N2C=CC3=C2N=CN=C3N)CO)O)O
SMILES (isomeric)	C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC3=C2N=CN=C3N)CO)O)O
Molecular Formula	C12H16N4O4
Molecular Weight (g/mol)	280.284
InChl	InChI=1S/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/m1/s1
Structural Information
Clinical Information
Biological Information
Primary Indication (Disease Category)	Infectious Disease
Primary Indication (Disease)	Viral infection
Secondary Indication	Zika virus (ZIKV) NA MR766
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	in-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Vero
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	1.3 μM
Secondary Indication (Cell based assay)	Plaque assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	EC50 [ 50 % ]
Reference	Zmurko J, Marques RE, Schols D, Verbeken E, Kaptein SJ, Neyts J..The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika V.PLoS Negl Trop Dis. 2016 May 10;10(5):e0004695. doi: 10.1371/journal.pntd.0004695. eCollection 2016 PMID:27163257
Comment	AG129 mice can generate an antibody response, and have been used in dengue vaccine studies, the model can also be used to assess the efficacy of ZIKV vaccines.