Chemical Information
Antiviral agent ID	DrugRepV_1917
Antiviral agent name	Chloroquine
IUPAC Name	4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
SMILES (canonical)	CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl
Molecular Formula	C18H26ClN3
Molecular Weight (g/mol)	319.877
InChl	InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)
Structural Information
Clinical Information
Category	Antiparasitic products, Insectisides and Repellents
Primary Indication (Clinical trial phases)	Approved
Biological Information
Primary Indication (Disease Category)	Infectious Disease
Primary Indication (Disease)	Malaria
Primary Indication (Drug target/Mode of Action)	Glypican 3 isoform 2
Secondary Indication	Zika virus (ZIKV) NA PLCal_ZV
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Potential drug target)	Endocytosis
Secondary Indication (Model system) [cell lines/ animal models]	Vero
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Time of drug delivery)	Post infection
Secondary Indication (Duration of drug delivery)	12 hours
Secondary Indication (Drug concentration)	20 μM
Secondary Indication (Cell based assay)	Time of addition assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	Percentage Inhibition [ 62.5 % ]
Reference	Han Y, Mesplède T, Xu H, Quan Y, Wainberg MA..The antimalarial drug amodiaquine possesses anti-ZIKA virus activities..J Med Virol. 2018 May;90(5):796-802. doi: 10.1002/jmv.25031. Epub 2018 Feb 21. PMID:29315671
Comment	Amodiaquine (AQ) may be efficacious for the treatment of ZIKV infection. Amodiaquine (AQ) and chloroquine (CQ) may modulate cellular factors involved in the entry of ZIKV into host cells.