Chemical Information
Antiviral agent ID	DrugRepV_1851
Antiviral agent name	Pipofezine
IUPAC Name	5-methyl-3-(4-methylpiperazin-1-yl)pyridazino[3,4-b][1,4]benzoxazine
SMILES (canonical)	CN1CCN(CC1)C2=NN=C3C(=C2)N(C4=CC=CC=C4O3)C
Molecular Formula	C16H19N5O
Molecular Weight (g/mol)	297.362
InChl	InChI=1S/C16H19N5O/c1-19-7-9-21(10-8-19)15-11-13-16(18-17-15)22-14-6-4-3-5-12(14)20(13)2/h3-6,11H,7-10H2,1-2H3
Structural Information
Clinical Information
Category	Antidepressant
Biological Information
Primary Indication (Disease Category)	Non Infectious Disease
Primary Indication (Disease)	Depressive disorders
Secondary Indication	Zika virus (ZIKV) NA MR766
Secondary Indication (Approaches)	Experimental-HTS
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	hNPCs
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	1 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Cell based assay)	Cell viability assay
Secondary Indication (Change)	No significant effect
Secondary Indication (Type of Inhibition)	Percentage Inhibition [ 0 % ]
Reference	Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F,.Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.Nat Med. 2016 Oct;22(10):1101-1107. doi: 10.1038/nm.4184. Epub 2016 Aug 29. PMID:27571349
Comment	The identified compounds that either inhibit ZIKV infection or suppress infection-induced caspase-3 activity in different neural cells