Chemical Information | |
Antiviral agent ID | DrugRepV_1780 | |
Antiviral agent name | Pipofezine | |
IUPAC Name | 5-methyl-3-(4-methylpiperazin-1-yl)pyridazino[3,4-b][1,4]benzoxazine | |
SMILES (canonical) | CN1CCN(CC1)C2=NN=C3C(=C2)N(C4=CC=CC=C4O3)C | |
Molecular Formula | C16H19N5O | |
Molecular Weight (g/mol) | 297.362 | |
InChl | InChI=1S/C16H19N5O/c1-19-7-9-21(10-8-19)15-11-13-16(18-17-15)22-14-6-4-3-5-12(14)20(13)2/h3-6,11H,7-10H2,1-2H3 | |
Structural Information | |
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Clinical Information | |
Category | Antidepressant
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Biological Information | |
Primary Indication (Disease Category) | Non Infectious Disease
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Primary Indication (Disease) | Depressive disorders
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Secondary Indication | Zika virus (ZIKV) NA MR766 | |
Secondary Indication (Approaches) | Experimental-HTS | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | SNB-19
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Secondary Indication (Mode of viral infection) | Adsorption
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Secondary Indication (Viral titer) | 1 MOI
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Cell based assay) | Cell viability assay
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Secondary Indication (Change) | No significant effect
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Secondary Indication (Type of Inhibition) | Percentage Inhibition [ 0 % ] | |
Reference | Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F,.Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.Nat Med. 2016 Oct;22(10):1101-1107. doi: 10.1038/nm.4184. Epub 2016 Aug 29. PMID:27571349
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Comment | The identified compounds that either inhibit ZIKV infection or suppress infection-induced caspase-3 activity in different neural cells
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