Chemical Information
Antiviral agent ID	DrugRepV_1736
Antiviral agent name	Drometrizole
IUPAC Name	2-(benzotriazol-2-yl)-4-methylphenol
SMILES (canonical)	C1=CC(=C(C=C1)O)N2N=C3C=CC=CC3=N2
Molecular Formula	C13H11N3O
Molecular Weight (g/mol)	225.251
InChl	InChI=1S/C13H11N3O/c1-9-6-7-13(17)12(8-9)16-14-10-4-2-3-5-11(10)15-16/h2-8,17H,1H3
Synonyms	Drometrizole | Benazol P | Tinuvin P | 2-(2H-Benzotriazol-2-yl)-p-cresol
Structural Information
Clinical Information
Biological Information
Secondary Indication	Zika virus (ZIKV) NA MR766
Secondary Indication (Approaches)	Experimental-HTS
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	SNB-19
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	1 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Cell based assay)	Cell viability assay
Secondary Indication (Change)	No significant effect
Secondary Indication (Type of Inhibition)	Percentage Inhibition [ 0 % ]
Reference	Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F,.Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.Nat Med. 2016 Oct;22(10):1101-1107. doi: 10.1038/nm.4184. Epub 2016 Aug 29. PMID:27571349
Comment	The identified compounds that either inhibit ZIKV infection or suppress infection-induced caspase-3 activity in different neural cells