Chemical Information | |
Antiviral agent ID | DrugRepV_1732 | |
Antiviral agent name | Diphenyl isophthalate | |
IUPAC Name | diphenyl benzene-1,3-dicarboxylate | |
SMILES (canonical) | C1=CC=C(C=C1)OC(=O)C2=CC(=CC=C2)C(=O)OC3=CC=CC=C3 | |
Molecular Formula | C20H14O4 | |
Molecular Weight (g/mol) | 318.328 | |
InChl | InChI=1S/C20H14O4/c21-19(23-17-10-3-1-4-11-17)15-8-7-9-16(14-15)20(22)24-18-12-5-2-6-13-18/h1-14H | |
Common Name | Diphenylisophthalate | |
Synonyms | Diphenyl m-phthalate | diphenyl benzene-1,3-dicarboxylate | Isophthalic Acid Diphenyl Ester | 1,3-Benzenedicarboxylic acid, 1,3-diphenyl ester | |
Structural Information | |
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Clinical Information | |
Biological Information | |
Secondary Indication | Zika virus (ZIKV) NA MR766 | |
Secondary Indication (Approaches) | Experimental-HTS | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | SNB-19
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Secondary Indication (Mode of viral infection) | Adsorption
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Secondary Indication (Viral titer) | 1 MOI
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Cell based assay) | Cell viability assay
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Secondary Indication (Change) | No significant effect
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Secondary Indication (Type of Inhibition) | Percentage Inhibition [ 0 % ] | |
Reference | Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F,.Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.Nat Med. 2016 Oct;22(10):1101-1107. doi: 10.1038/nm.4184. Epub 2016 Aug 29. PMID:27571349
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Comment | The identified compounds that either inhibit ZIKV infection or suppress infection-induced caspase-3 activity in different neural cells
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