Chemical Information
Antiviral agent ID	DrugRepV_1714
Antiviral agent name	Fenaminosulf
IUPAC Name	sodium;N-[4-(dimethylamino)phenyl]iminosulfamate
SMILES (canonical)	CN(C)C1=CC=C(C=C1)N=NS(=O)(=O)[O-].[Na+]
Molecular Formula	C8H10N3NaO3S
Molecular Weight (g/mol)	251.236
InChl	InChI=1S/C8H11N3O3S.Na/c1-11(2)8-5-3-7(4-6-8)9-10-15(12,13)14;/h3-6H,1-2H3,(H,12,13,14);/q;+1/p-1
Structural Information
Clinical Information
Biological Information
Secondary Indication	Zika virus (ZIKV) NA MR766
Secondary Indication (Approaches)	Experimental-HTS
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Astrocytes
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	1 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Cell based assay)	Cell viability assay
Secondary Indication (Change)	No significant effect
Secondary Indication (Type of Inhibition)	Percentage Inhibition [ 0 % ]
Reference	Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F,.Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.Nat Med. 2016 Oct;22(10):1101-1107. doi: 10.1038/nm.4184. Epub 2016 Aug 29. PMID:27571349
Comment	The identified compounds that either inhibit ZIKV infection or suppress infection-induced caspase-3 activity in different neural cells