Chemical Information | |
Antiviral agent ID | DrugRepV_1703 | |
Antiviral agent name | 2-Ethoxylethyl-p-methoxycinnamate | |
IUPAC Name | 2-ethoxyethyl (E)-3-(4-methoxyphenyl)prop-2-enoate | |
SMILES (canonical) | CCOCCOC(=O)C=CC1=CC=C(C=C1)OC | |
SMILES (isomeric) | CCOCCOC(=O)/C=C/C1=CC=C(C=C1)OC | |
Molecular Formula | C14H18O4 | |
Molecular Weight (g/mol) | 250.294 | |
InChl | InChI=1S/C14H18O4/c1-3-17-10-11-18-14(15)9-6-12-4-7-13(16-2)8-5-12/h4-9H,3,10-11H2,1-2H3/b9-6+ | |
Structural Information | |
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Clinical Information | |
Biological Information | |
Secondary Indication | Zika virus (ZIKV) NA MR766 | |
Secondary Indication (Approaches) | Experimental-HTS | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | Astrocytes
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Secondary Indication (Mode of viral infection) | Adsorption
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Secondary Indication (Viral titer) | 1 MOI
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Cell based assay) | Cell viability assay
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Secondary Indication (Change) | No significant effect
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Secondary Indication (Type of Inhibition) | Percentage Inhibition [ 0 % ] | |
Reference | Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F,.Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.Nat Med. 2016 Oct;22(10):1101-1107. doi: 10.1038/nm.4184. Epub 2016 Aug 29. PMID:27571349
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Comment | The identified compounds that either inhibit ZIKV infection or suppress infection-induced caspase-3 activity in different neural cells
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