Chemical Information | |
Antiviral agent ID | DrugRepV_1677 | |
Antiviral agent name | Phenazopyridine Hydrochloride | |
IUPAC Name | 3-phenyldiazenylpyridine-2,6-diamine;hydrochloride | |
SMILES (canonical) | C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.Cl | |
Molecular Formula | C11H12ClN5 | |
Molecular Weight (g/mol) | 249.702 | |
InChl | InChI=1S/C11H11N5.ClH/c12-10-7-6-9(11(13)14-10)16-15-8-4-2-1-3-5-8;/h1-7H,(H4,12,13,14);1H | |
Common Name | Phenazopyridine HCl | |
Synonyms | 3-Phenylazo-2,6-diaminopyridine hydrochloride | Phenazopyridinium chloride | 3-Phenylazo-2,6-diaminopyridine Monohydrochloride | 2,6-Diamino-3-(phenylazo)pyridine monohydrochloride | Phenylazodiaminopyridine hydrochloride | Phenylazo-alpha,alpha'-diaminopyridine monohydrochloride | |
Structural Information | |
|
|
Clinical Information | |
Category | Genito Urinary System and Sex Hormones
| |
Primary Indication (Clinical trial phases) | Approved
| |
Biological Information | |
Primary Indication (Disease Category) | Non Infectious Disease
| |
Primary Indication (Disease) | Urinary tract infection
| |
Secondary Indication | Zika virus (ZIKV) NA MR766 | |
Secondary Indication (Approaches) | Experimental-HTS | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | Astrocytes
| |
Secondary Indication (Mode of viral infection) | Adsorption
| |
Secondary Indication (Viral titer) | 1 MOI
| |
Secondary Indication (Mode of drug delivery) | Culture
| |
Secondary Indication (Cell based assay) | Cell viability assay
| |
Secondary Indication (Change) | No significant effect
| |
Secondary Indication (Type of Inhibition) | Percentage Inhibition [ 0 % ] | |
Reference | Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F,.Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.Nat Med. 2016 Oct;22(10):1101-1107. doi: 10.1038/nm.4184. Epub 2016 Aug 29. PMID:27571349
| |
Comment | The identified compounds that either inhibit ZIKV infection or suppress infection-induced caspase-3 activity in different neural cells
| |