Chemical Information
Antiviral agent ID	DrugRepV_1667
Antiviral agent name	Tiaprofenic Acid
IUPAC Name	2-(5-benzoylthiophen-2-yl)propanoic acid
SMILES (canonical)	CC(C1=CC=C(S1)C(=O)C2=CC=CC=C2)C(=O)O
Molecular Formula	C14H12O3S
Molecular Weight (g/mol)	260.307
InChl	InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)
Synonyms	Tiaprofensaeure | 2-(5-benzoylthiophen-2-yl)propanoic acid | 5-Benzoyl-alpha-methyl-2-thiopheneacetic acid | 2-[5-(phenylcarbonyl)-2-thienyl]propanoic acid | alpha-methyl-5-benzoyl-2-thienylacetic acid
Structural Information
Clinical Information
Category	Musculo-Skeletal System
Primary Indication (Clinical trial phases)	Approved
Biological Information
Primary Indication (Disease Category)	Non Infectious Disease
Primary Indication (Disease)	Arthritic pain
Primary Indication (Drug target/Mode of Action)	Peroxisome proliferator-activated receptor gamma
Secondary Indication	Zika virus (ZIKV) NA MR766
Secondary Indication (Approaches)	Experimental-HTS
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	Astrocytes
Secondary Indication (Mode of viral infection)	Adsorption
Secondary Indication (Viral titer)	1 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Cell based assay)	Cell viability assay
Secondary Indication (Change)	No significant effect
Secondary Indication (Type of Inhibition)	Percentage Inhibition [ 0 % ]
Reference	Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F,.Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.Nat Med. 2016 Oct;22(10):1101-1107. doi: 10.1038/nm.4184. Epub 2016 Aug 29. PMID:27571349
Comment	The identified compounds that either inhibit ZIKV infection or suppress infection-induced caspase-3 activity in different neural cells