| Chemical Information | |
| Antiviral agent ID | DrugRepV_1333 | |
| Antiviral agent name | Minoxidil |  |
| IUPAC Name | 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine |  |
| SMILES (canonical) | C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O | |
| Molecular Formula | C9H15N5O | |
| Molecular Weight (g/mol) | 209.25 | |
| InChl | InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2 | |
| Common Name | Minoxidil | |
| Synonyms | 2,4-Diamino-6-piperidinopyrimidine 3-oxide | 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide | Alostil | Apo-gain | Lonolox | Minossidile | Minoxidil | Minoxidilum | Minoximen | Normoxidil | Regaine | Tricoxidil | |
| Structural Information | |
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| Clinical Information | |
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Category | Cardiovascular agents; Dermatologicals
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Primary Indication (Clinical trial phases) | Approved, Investigational
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| Biological Information | |
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Primary Indication (Disease Category) | Non Infectious Disease
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Primary Indication (Disease) | Hypertension | Alopecia
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Primary Indication (Drug target/Mode of Action) | Male-enhanced antigen 1
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Secondary Indication | Zika virus (ZIKV) NA MEX_I_7 |   |
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Secondary Indication (Approaches) | Experimental-HTS | |
| Secondary Indication (Methods) | In-vitro | |
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Secondary Indication (Model system) [cell lines/ animal models] | Huh-7
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Secondary Indication (Mode of viral infection) | Adsorption
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Secondary Indication (Viral titer) | 0.4 MOI
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Time of drug delivery) | Pre infection (1 hour)
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Secondary Indication (Duration of drug delivery) | 24-26 hours
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Secondary Indication (Drug concentration) | 13.8 μM
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Secondary Indication (Cell based assay) | Fluorescence-based assay
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Secondary Indication (Change) | Decrease
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Secondary Indication (Type of Inhibition) | Percentage Inhibition [ 42.195 % ] | |
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Reference | Barrows NJ, Campos RK, Powell ST, Prasanth KR, Schott-Lerner G, Soto-Acosta R, Galarza-Muñoz.A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection..Cell Host Microbe. 2016 Aug 10;20(2):259-70. doi: 10.1016/j.chom.2016.07.004. Epub 2016 Jul 28. PMID:27476412
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Comment | Several drugs reduced ZIKV infection across multiple cell types. This study identifies drugs that could be tested in clinical studies of ZIKV infection and provides a resource of small molecules to study ZIKV pathogenesis.
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