Chemical Information | |
Antiviral agent ID | DrugRepV_0203 | |
Antiviral agent name | Clarithromycin | |
IUPAC Name | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione | |
SMILES (canonical) | CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O | |
SMILES (isomeric) | CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O | |
Molecular Formula | C38H69NO13 | |
Molecular Weight (g/mol) | 747.96 | |
InChl | InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1 | |
Common Name | Clarithromycin | |
Synonyms | 6-O-methyl erythromycin | 6-O-Methylerythromycin | 6-O-Methylerythromycin a | CLA | CLARITHROMYCIN | Clarithromycina | Clarithromycine | Clarithromycinum | |
Structural Information | |
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Clinical Information | |
Category | Antiinfectives For Systemic Use
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Primary Indication (Clinical trial phases) | Approved
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Biological Information | |
Primary Indication (Disease Category) | Infectious Disease
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Primary Indication (Disease) | Microbial infections
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Primary Indication (Drug target/Mode of Action) | Hydroxyacid oxidase 2
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Secondary Indication | Ebola virus (EBOV) NA VLP | |
Secondary Indication (Approaches) | Experimental | |
Secondary Indication (Methods) | In-vitro | |
Secondary Indication (Model system) [cell lines/ animal models] | HeLa
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Secondary Indication (Mode of viral infection) | Adsorption
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Secondary Indication (Viral titer) | 1 μl/well
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Secondary Indication (Mode of drug delivery) | Culture
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Secondary Indication (Time of drug delivery) | Pre infection
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Secondary Indication (Drug concentration) | 4.33 μM
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Secondary Indication (Cell based assay) | Immunoflourescence assay
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Secondary Indication (Change) | Decrease
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Secondary Indication (Type of Inhibition) | IC50 [ 50 % ] | |
Reference | Sun W, He S, Martínez-Romero C, Kouznetsova J, Tawa G, Xu M, Shinn P, Fisher E, Long Y, Motab.Synergistic drug combination effectively blocks Ebola virus infection..Antiviral Res. 2017 Jan;137:165-172. doi: 10.1016/j.antiviral.2016.11.017. Epub 2016 Nov 24. PMID:27890675
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Comment | Two sets of three-drug combinations, toremifene-mefloquine-posaconazole and toremifene- clarithromycin-posaconazole, were identified that effectively blocked EBOV entry and were further validated for inhibition of live EBOV infection. The individual drug concentrations in the combinations were reduced to clinically relevant levels. The findings identify the drug combinations with potential to treat EBOV infection.
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