• NipahVR Overview
• Nipah virus (NiV) is an emerging and priority pathogen from the Paramyxoviridae family.


• There is no approved vaccine or therapeutics is available for Nipah infection.


• NipahVR, an integrative platform dedicated for the multi-targeted putative therapeutics and epitome for the nipah virus.


• It is structured into different sections i.e. genomes, codon usage, phylogenomics, molecular diagnostic primers, therapeutics (siRNAs, sgRNAs, miRNAs) and vacccine epitopes (B-cell epitopes, CTL epitopes, MHC-I and -II binders).


• Potentially efficient therapeutic regimens targeting different NiV proteins and genes were anticipated and projected.


• Detail organization
  
  
• Genome Search
• NipaVR resource is equipped with the advance genome search facility for the easy navigation.
• Nipah genomes can be searched using different search options such as host/source (i.e. human, pig, bat), geographical region (Asia), and country (India, Bangladesh, Malaysia) with the detailed meta-information.
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• Therapeutics
• RNA based therapeutics interventions provide alternate ways to counter this lethal viruses through silencing the individual genes.
• We have analyzed and also provided compendium of potent siRNAs, miRNAs and sgRNAs for NiV genes.



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• Epitome
• We have predicted potential vaccine candidates for Nipah virus using various compuational algorithm. The peptides can sorted at any header. In this section, we have summarized all the peptides that were able to induce diverse arms of immune response.


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• Diagnostic primers
• We have collected primer pairs utilized for the detection of Nipah virus. Detailed information about primers like respective primer name, sequence of primer, its orientation (forward and reverse), genomic region and study reference is provided.
• Overall, 55 forward and 53 reverse primers were reported against different genes of nipah virus and compiled.
• We have also designed primer pairs for each genes utilizing PrimerDesign-M tool. In total, 2 primer pairs for N-gene; 6 primer pairs for P-gene; 3 primer pairs for M-gene; 6 primer pairs for F-gene; 1 primer pair for G-gene and 9 primer pairs for polymerase gene. Gene name, start-end and melting temperature (Tm) of primers were reported.
• These primers (experimental and designed) will be valuable for the detection and diagnosis of nipah virus.


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