Welcome to HSPMdb
HSPMdb is a first of its kind repository of experimentally validated Heat Shock Protein (Hsp) modulators (activators and inhibitors). It provides comprehensive information on biological and chemical properties of small synthetic Hsp modulators. The current version of HSPMdb catalogues 10223 entries of chemical compounds modulating activity of five major Hsps (Hsp100, Hsp90, Hsp70, Hsp60 and Hsp40) originated from 15 sources/organisms (for e.g. human, yeast, bacteria, Plasmodium falciparum, etc.) targeting 10 different diseases (for e.g. cancer, Alzheimer's disease, Malaria, etc.). Biological information of these modulators has been compiled under two major categories (i) enzymatic activity, and (ii) cellular activity. Under enzymatic activity field, a detailed information of type of enzymatic assay used, site of interaction of modulator, effect of modulator, and in vitro enzymatic modulation activities (IC50, EC50, DC50, EC50, Ki, Kd and percentage inhibition) has been provided. In cellular activity field, complete information of type of cell viability assays used, tested cell line, and cellular activities (percentage cell growth inhibition, EC50, GI50) has been compiled. Despite this, for each compound, database provides information on 2D/3D structure, and its physical, elemental and topological properties. HSPMdb is further linked to other important databases like PubMed, Uniprot and Pubchem.
Key features:
HSPMdb is integrated with various tools like simple search, advanced search, browse facility as well as a tool for structure based searching.
Searching Tools: HSPMdb provides simple and advanced search options for users to search the database. Users can perform keyword search using simple search while complex queries can be searched using advanced search option.
Browsing Tool: A user-friendly browsing interface has been developed where user can fetch the information on different fields like enzymatic activities and cellular activities.
Analysis Tool: This is an important tool for data analysis. Users can check how similar is their query molecule to the known inhibitors available in HSPMdb. This tool will assist researchers to identify Hsp inhibitors similar to their query molecule based on a similarity index. Thus, users can scan the whole repository of inhibitors for designing novel lead molecules.
