Accession_No PMID Target HSP_Name Organism Localization Enzymatic_activity Cellular_activity compound_Name IUPAC_Name SMILES Class Enzymatic_Inhibition Kd Ki IC50 EC50 DC50 RD_Index GI50 Site_of_Interaction Type_of_Enzymatic_Assay Percentage_Cell_ Cellular_assay HSP_client_protein_assay CC50 MIC_MBC Celllines Disease HSPMDB001484 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Hexachlorophene 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol Oc1c(Cl)cc(Cl)c(Cl)c1Cc2c(O)c(Cl)cc(Cl)c2Cl NIH, Spectrum, and Hit finder collection 80.21% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001485 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Tannic acid [2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5 trihydroxybenzoate Oc1cc(cc(O)c1O)C(=O)Oc2cc(cc(O)c2O)C(=O)OC[C@H]3O[C@@H](OC(=O)c4cc(O)c(O)c(OC(=O)c5cc(O)c(O)c(O)c5)c4)[C@H](OC(=O)c6cc(O)c(O)c(OC(=O)c7cc(O)c(O)c(O)c7)c6)[C@@H](OC(=O)c8cc(O)c(O)c(OC(=O)c9cc(O)c(O)c(O)c9)c8)[C@@H]3OC(=O)c%10cc(O)c(O)c(OC(=O)c%11cc(O)c(O)c(O)c%11)c%10 NIH, Spectrum, and Hit finder collection 79.79% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001486 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Cisplatin dichloroplatinum N.N.Cl[Pt]Cl NIH, Spectrum, and Hit finder collection 76.58% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001487 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA carboplatin cyclobutane-1,1-dicarboxylate platinum C1CC(C1)(C(=O)O)C(=O)O.N.N.[Pt] NIH, Spectrum, and Hit finder collection 73.75% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001488 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Theaflavin monogallates [(2R,3R)-5,7-dihydroxy-2-[3,4,5-trihydroxy-6-oxo-1-[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]benzo[7]annulen-8-yl]-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1C3=CC(=C(O)C4=C(O)C(=O)C=C(C=C34)[C@H]5Oc6cc(O)cc(O)c6C[C@H]5OC(=O)c7cc(O)c(O)c(O)c7)O NIH, Spectrum, and Hit finder collection 57.25% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001489 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Suramin 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate CC1=C(C=C(C(=O)NC2=CC=C(C=3C=C(C=C(C23)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C=C1)NC(C1=CC(=CC=C1)NC(NC1=CC(=CC=C1)C(NC1=C(C=CC(=C1)C(NC1=CC=C(C2=CC(=CC(=C12)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])=O)C)=O)=O)=O NIH, Spectrum, and Hit finder collection 50.83% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001490 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Gossypol-acetic acid complex 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde C(=O)C=1C(=C(C(=C2C=C(C(=C(C12)O)C1=C(C=C2C(=C(C(=C(C2=C1O)C=O)O)O)C(C)C)C)C)C(C)C)O)O NIH, Spectrum, and Hit finder collection 47.92%at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001491 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Hematein 4,6a,9,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-3-one Oc1cc2CC3(O)COC4=C(O)C(=O)C=CC4=C3c2cc1O NIH, Spectrum, and Hit finder collection 45.71% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001492 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Gossypol 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O NIH, Spectrum, and Hit finder collection 42.33% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001493 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA chlorophyllide Cu complex Na salt 3-[20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl-13-ethyl-3,7,12,17-tetramethyl-2,3-dihydroporphyrin-2,3-id-2-yl]propanoate CCC1=C2C=C3C(=C4C(=O)C(C(=C4[N-]3)C5=C(C(=C([N-]5)C=C6C(=C(C(=CC(=C1C)[N-]2)[N-]6)C=C)C)C)CCC(=O)[O-])C(=O)[O-])C.[Na+].[Na+].[Cu] NIH, Spectrum, and Hit finder collection 33.79% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001494 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Methacycline hydrochloride 4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide hydrochloride Cl.CN(C1C(C(=C(C2(C(C3=C(C4=C(C=CC=C4C(C3C(C12)O)=C)O)O)=O)O)O)C(=O)N)=O)C NIH, Spectrum, and Hit finder collection 33.33% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001495 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Sucralfate sodium [(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-bis(?1-alumanyloxysulfonyloxy)-2,5-bis(?1-alumanyloxysulfonyloxymethyl)oxolan-2-yl]oxy-3,5-bis(?1-alumanyloxysulfonyloxy)-6-(?1-alumanyloxysulfonyloxymethyl)oxan-4-yl]oxysulfonyloxyaluminum;hexadecahydrate O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Al]OS(=O)(=O)O[C@@H]1[C@](O[C@@H]([C@H]1OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])(COS(=O)(=O)O[Al])O[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al] NIH, Spectrum, and Hit finder collection 25.67% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001496 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Aurin tricarboxylic acid 5-[(3-carboxy-4-hydroxyphenyl)-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid OC(=O)c1cc(ccc1O)C(c2ccc(O)c(c2)C(O)=O)=C3C=CC(=O)C(=C3)C(O)=O NIH, Spectrum, and Hit finder collection 24.25% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001497 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Epigallocatechin 3,5-digallate (2R,3R)-7-hydroxy-5-(3,4,5-trihydroxybenzoyl)oxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate OC=1C=C(C(=O)O[C@H]2[C@H](OC3=CC(=CC(=C3C2)OC(C2=CC(=C(C(=C2)O)O)O)=O)O)C2=CC(=C(C(=C2)O)O)O)C=C(C1O)O NIH, Spectrum, and Hit finder collection 21.88% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001498 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Merbromin (2',7'-dibromo-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury(1+) Oc1cc2Oc3c([Hg+])c(O)c(Br)cc3C4(OC(=O)c5ccccc45)c2cc1Br NIH, Spectrum, and Hit finder collection 21.17% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001499 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Sennoside a (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@@H]4c5cccc(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O NIH, Spectrum, and Hit finder collection 19.92% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001500 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of chaperone activity NA Suramin 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate CC1=C(C=C(C(=O)NC2=CC=C(C=3C=C(C=C(C23)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C=C1)NC(C1=CC(=CC=C1)NC(NC1=CC(=CC=C1)C(NC1=C(C=CC(=C1)C(NC1=CC=C(C2=CC(=CC(=C12)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])=O)C)=O)=O)=O NIH, Spectrum, and Hit finder collection NA NA NA 10.1 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA NA HSPMDB001501 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 1 (S)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl acetyl-L-prolinate COC(=O)[C@H](COC(=O)[C@@H]1CCCN1C(C)=O)NC(=O)OCc2ccccc2 Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.016 ug/ml B. subtilis Bacterial infection HSPMDB001502 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 2 (2S,3S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutan-2-yl acetyl-L-prolinate COC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@H](C)OC(=O)[C@@H]2CCCN2C(C)=O Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml B. subtilis Bacterial infection HSPMDB001503 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 3 (2R,3S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutan-2-yl acetyl-L-prolinate COC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@@H](C)OC(=O)[C@@H]2CCCN2C(C)=O Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml B. subtilis Bacterial infection HSPMDB001504 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 (S)-2-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-3-methoxy-3-oxopropyl acetyl-L-prolinate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H](COC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OC Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001505 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 5 Methyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2-enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OC Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 8 ug/ml B. subtilis Bacterial infection HSPMDB001506 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 (S)-2-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-3-methoxy-3-oxopropyl acetyl-L-prolinate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H](COC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001507 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 5 Methyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2-enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 8 ug/ml B. subtilis Bacterial infection HSPMDB001508 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 6 (2S,3S)-3-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-4-methoxy-4-oxobutan-2-yl acetyl-L-prolinate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]([C@H](C)OC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001509 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 (2R,3S)-3-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-4-methoxy-4-oxobutan-2-yl acetyl?L-prolinate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]([C@@H](C)OC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001510 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 8 Methyl (S,E)-2-(3-cyclohexylacrylamido)-3-(3,5-difluorophenyl)propanoate COC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)/C=C/C2CCCCC2 N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001511 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 9 Methyl (S)-3-(3,5-difluorophenyl)-2-((2E,4E,6E)-octa-2,4,6-trienamido)propanoate COC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)\C=C\C=C\C=C\C N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001512 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 10 Methyl (2S)-3-(3,5-difluorophenyl)-2-((E)-5-methylhept-2-enamido)propanoate CCC(C)C/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 8 ug/ml B. subtilis Bacterial infection HSPMDB001513 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 11 Methyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2?enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA >128 ug/ml B. subtilis Bacterial infection HSPMDB001514 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 12 Methyl (S)-2-(3-cyclohexylpropanamido)-3-(3,5-difluorophenyl)propanoate COC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)CCC2CCCCC2 N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml B. subtilis Bacterial infection HSPMDB001515 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 13 Methyl (E)-hept-2-enoyl-L-phenylalaninate CCCC/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml B. subtilis Bacterial infection HSPMDB001516 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 14 Methyl (E)-hept-2-enoyl-L-leucinate CCCC/C=C/C(=O)N[C@@H](CC(C)C)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA >128 ug/ml B. subtilis Bacterial infection HSPMDB001517 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 15 3-(3,5-difluorophenyl)-2-[(2E)-hex-2-enamido]propanoic acid CCC/C=C/C(=O)NC(Cc1cc(F)cc(F)c1)C(O)=O N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml B. subtilis Bacterial infection HSPMDB001518 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 16 (S,E)-N-(1-amino-3-(3,5-difluorophenyl)-1-oxopropan-2-yl)hept-2-enamide CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(N)=O N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001519 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 17 (S,E)-N-(3-(3,5-difluorophenyl)-1-(methylamino)-1-oxopropan-2-yl)hept-2-enamide CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)NC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001520 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 18 (S,E)-N-(3-(3,5-difluorophenyl)-1-(dimethylamino)-1-oxopropan-2-yl)hept-2-enamide CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N(C)C N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml B. subtilis Bacterial infection HSPMDB001521 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 19 (furan-2-yl)methyl (2S)-3-(3,5-difluorophenyl)-2-[(2E)-hex-2-enamido]propanoate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCc2occc2 N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001522 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 20 Benzyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2?enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCc2ccccc2 N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA >128 ug/ml B. subtilis Bacterial infection HSPMDB001523 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 21 Prop-2-yn-1-yl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2-enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCC#C N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 2 ug/ml B. subtilis Bacterial infection HSPMDB001524 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 1 (3Z)-3-[3-(4-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5- ylidene]-5-nitro-1,3-dihydro-2H-indol-2-one [O-][N+](=O)c1ccc2NC(=O)\C(=C3/SC(=S)N(C3=O)c4ccc(Cl)cc4)c2c1 MyriaScreen diversity collection NA NA NA 10 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001525 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 2 (5Z)-5-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-phenyl1,3-thiazolidine-2,4-dione Brc1ccc2NC(=O)C(=C/3SC(=O)N(C3=O)c4ccccc4)/c2c1 MyriaScreen diversity collection NA NA NA 30 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001526 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA NA NA 7 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001527 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 4 3,4-Dichloro-N-(3-nitrophenyl)-1-benzothiophene-2-carboxamide [O-][N+](=O)c1cccc(NC(=O)c2sc3cccc(Cl)c3c2Cl)c1 MyriaScreen diversity collection NA NA NA 90 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001528 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 5 (4Z)-1-(4-Chlorophenyl)-4-{4-[(4-fluorobenzyl)oxy]-3- methoxybenzylidene}-3,5-pyrazolidinedione COc1cc(ccc1OCc2ccc(F)cc2)/C=C3/C(=O)NN(C3=O)c4ccc(Cl)cc4 MyriaScreen diversity collection NA NA NA 7.5 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001529 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA NA NA 20 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001530 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 7 (3Z)-3-(3-Allyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3- dihydro-2H-indol-2-one C=CCN1C(=S)S\C(C1=O)=C2/C(=O)Nc3ccccc23 MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001531 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 8 2-(4-Chloro-5-methyl-3-nitro-1H-pyrazol-1-yl)-N-[3-(2,4- dichlorophenoxy)-5-nitrophenyl]acetamide Cc1n(CC(=O)Nc2cc(Oc3ccc(Cl)cc3Cl)cc(c2)[N+]([O-])=O)nc(c1Cl)[N+]([O-])=O MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001532 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 9 2-[(5Z)-5-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2- thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid CC(C)C(N1C(=S)SC(/C1=O)=C/2C(=O)Nc3ccc(Br)cc23)C(O)=O MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001533 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 10 1-Ethyl-4-hydroxy-N-(3-hydroxyphenyl)-2-oxo-1,2-dihydro-3- quinolinecarboxamide CCN1C(=O)C(=C(O)c2ccccc12)C(=O)Nc3cccc(O)c3 MyriaScreen diversity collection NA NA NA 65 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001534 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 11 (1E,3E,5E)-N,N'-Diphenyl-1,3,5-hexatriene-1,6-diamine hydrochloride (1:1) Cl.N(\C=C\C=C\C=C\Nc1ccccc1)c2ccccc2 MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001535 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 12 (3Z)-5-Bromo-3-[3-(3-methoxypropyl)-4-oxo-2-thioxo-1,3- thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one COCCCN1C(=S)SC(/C1=O)=C/2C(=O)Nc3ccc(Br)cc23 MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001536 23961953 Hsp100 ClpB Bacteria Cytosol NA Antibacterial activity 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 60-100 uM E. coli strains MC4100 Bacterial infection HSPMDB001537 23961953 Hsp100 ClpB Bacteria Cytosol NA Antibacterial activity 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 60-100 uM E. coli strains MC4100 Bacterial infection HSPMDB001538 23961953 Hsp100 NA Human NA NA Antiproliferative activity 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA 30-50% MTT viability assay NA NA NA HeLa Bacterial infection HSPMDB001539 23961953 Hsp100 NA Human NA NA Antiproliferative activity 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA 30-50% MTT viability assay NA NA NA HeLa Bacterial infection HSPMDB001540 23961953 Hsp100 NA Human NA NA Antiproliferative activity 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA 30-50% MTT viability assay NA NA NA CHO Bacterial infection HSPMDB001541 23961953 Hsp100 NA Human NA NA Antiproliferative activity 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA 30-50% MTT viability assay NA NA NA CHO Bacterial infection HSPMDB001542 23961953 Hsp100 ClpB Bacteria Cytosol Binding affinity NA 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA 12.9 NA NA NA NA NA NA NA Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001543 23961953 Hsp100 ClpB Bacteria Cytosol Binding affinity NA 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA 19 NA NA NA NA NA NA NA Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001544 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.125 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001545 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.25 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001546 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001547 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001548 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001549 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001550 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 4 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001551 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 16 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001552 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.125 ug/ml L. monocytogenes Bacterial infection HSPMDB001553 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001554 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001555 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001556 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001557 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001558 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001559 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001560 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001561 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001562 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml L. monocytogenes Bacterial infection HSPMDB001563 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001564 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001565 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001566 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001567 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001568 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001569 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001570 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001571 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 16 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001572 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml L. monocytogenes Bacterial infection HSPMDB001573 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001574 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001575 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001576 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001577 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001578 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001579 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001580 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001581 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001582 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml L. monocytogenes Bacterial infection HSPMDB001583 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001584 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 4 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001585 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001586 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001587 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001588 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001589 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001590 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001591 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 8 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001592 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml L. monocytogenes Bacterial infection HSPMDB001593 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001594 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001595 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001596 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001597 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001598 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001599 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001600 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001601 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001602 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml L. monocytogenes Bacterial infection HSPMDB001603 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001604 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001605 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001606 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001607 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001608 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001609 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001610 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001611 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001612 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001613 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 16 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001614 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001615 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001616 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001617 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001618 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001619 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001620 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1A (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.3,n=14.6 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001621 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1B (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.7, n=11.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001622 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 3.2, n=16.1 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001623 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1A (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.3, n=15.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001624 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1B (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.7, n=11.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001625 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 3.3, n=16.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001626 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1A (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.4, n=14.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001627 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1B (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.7, n=14.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001628 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 4.1, n=14.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001629 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1A (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 1.1 NA NA NA NA NA NA Nucleotide binding domain Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001630 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1B (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 1.4 NA NA NA NA NA NA Nucleotide binding domain Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001631 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 128 NA NA NA NA NA NA Nucleotide binding domain Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001632 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 334 5,11-Dihydro-11-(3-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Oc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001633 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 358 5,11-Dihydro-11-(3-bromo-5-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin12-one Oc1cc(Br)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001634 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 369 2-(3-hydroxyphenyl)-17-oxo-N-(prop-2-yn-1-yl)-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide OC=1C=C(C=CC1)[S]1C=2C(C3=CC(=CC=C3C2NC=2C=CC=CC12)C(=O)NCC#C)=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001635 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 344 5,11-Dihydro-11-(3-hydroxy-5-methoxyphenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one COc1cc(O)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001636 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 347 5,11-Dihydro-11-(3,5-dihydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Oc1cc(O)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001637 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 336 10-(thiophen-2-yl)-9-thia-2-azatetracyclo[9.7.0.0³,?.0¹³,¹?]octadeca-1(11),3(8),4,6,13(18),14,16-heptaen-12-one O=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5sccc5 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001638 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 376 N-{2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethyl}-2-(3-hydroxyphenyl)-17-oxo-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide C(CC#C)C1(N=N1)CCNC(=O)C1=CC=C2C=3NC=4C=CC=CC4[S](C3C(C2=C1)=O)C1=CC(=CC=C1)O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001639 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 348 11-(3-Fluorophenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Fc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001640 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 366 2,3-Dichloro-5,11-dihydro-11-(3-hydroxyphenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one Oc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5cc(Cl)c(Cl)cc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001641 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 350 5,11-Dihydro-11-(3-hydroxy-5-(hex-5-ynyloxy)-phenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one Oc1cc(OCCCCC#C)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001642 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 353 4-{12-oxo-9-thia-2-azatetracyclo[9.7.0.0³,?.0¹³,¹?]octadeca-1(11),3(8),4,6,13(18),14,16-heptaen-10-yl}phenyl formate O=COc1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001643 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 356 2-Ethynyl-5,11-dihydro-11-(3-hydroxyphenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one Oc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5cc(ccc45)C#C Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001644 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 340 5,11-Dihydro-11-phenyl-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one O=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5ccccc5 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001645 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 343 5,11-Dihydro-11-(4-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Oc1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001646 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 341 5,11-Dihydro-11-(3-methoxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one COc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001647 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 368 2-(3-hydroxyphenyl)-17-oxo-N-(prop-2-yn-1-yl)-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-13-carboxamide OC=1C=C(C=CC1)[S]1C=2C(C3=CC=C(C=C3C2NC=2C=CC=CC12)C(=O)NCC#C)=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001648 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 359 5,11-Dihydro-11-(3-aminophenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Nc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001649 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 370 2-(3-hydroxyphenyl)-17-oxo-N-(prop-2-yn-1-yl)-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-13-carboxamide OC=1C=C(C=CC1)[S]1C=2C(C3=CC=C(C=C3C2NC=2C=CC=CC12)C(=O)NCC#C)=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001650 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 351 5,11-Dihydro-11-(2-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Oc1ccccc1C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001651 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 367 5,11-Dihydro-11-(3-(hydroxymethyl)phenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin12-one OCc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001652 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 355 11-(3-hydroxyphenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10- dioxide Oc1cccc(c1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001653 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 352 10-(pyridin-2-yl)-9-thia-2-azatetracyclo[9.7.0.0³,?.0¹³,¹?]octadeca-1(11),3(8),4,6,13(18),14,16-heptaen-12-one O=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5ccccn5 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001654 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 345 5,11-Dihydro-11-(3-hydroxyphenyl)-8-methoxy-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one COc1ccc2NC3=C(C(Sc2c1)c4cccc(O)c4)C(=O)c5ccccc35 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001655 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 346 11-(4-Fluorophenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Fc1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001656 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 349 11-(4-Carboxyphenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one OC(=O)c1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001657 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 360 11-(4-(trifluoromethyl)phenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one FC(F)(F)c1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001658 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 354 11-(4-fluorophenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10-dioxide Fc1ccc(cc1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001659 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 374 N-{2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethyl}-2-(3-methoxyphenyl)-17-oxo-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide [H]C1=C(C=C2C(=O)C3=C(NC4=C(C=CC=C4)[S]3C3=CC=CC(OC)=C3)C2=C1)C(=O)NCCC1(CCC#C)N=N1 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001660 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 362 11-(3-methoxyphenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10- dioxide COc1cccc(c1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001661 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 364 11-(4-(trifluoromethyl)phenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10-dioxide FC(F)(F)c1ccc(cc1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001662 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 363 11-([1,1'-biphenyl]-4-yl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10- dioxide O=C1c2ccccc2C3=C1C(c4ccc(cc4)c5ccccc5)[S](=O)(=O)c6ccccc6N3 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001663 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 365 11-([1,1'-biphenyl]-4-yl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one O=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5ccc(cc5)c6ccccc6 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001664 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 375 N-{2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethyl}-2-(3-methoxyphenyl)-17-oxo-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide [H]C1=C(C=C2C(=O)C3=C(NC4=C(C=CC=C4)[S]3C3=CC=CC(OC)=C3)C2=C1)C(=O)NCCC1(CCC#C)N=N1 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001665 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 2 Trans 4-butyl 3-pentyloxetan-2-one CCCCC[C@H]1[C@H](CCCC)OC1=O Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 250 ug/ml M. smegmatis (mc2155) Tuberculosis HSPMDB001666 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 3 Trans-4-butyl 3-heptyloxetan-2-one CCCCCCC[C@H]1[C@H](CCCC)OC1=O Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 150 ug/ml M. smegmatis (mc2155) Tuberculosis HSPMDB001667 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-one CCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 45 ug/ml M. smegmatis (mc2155) Tuberculosis HSPMDB001668 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2 Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 10 ug/ml M. smegmatis (mc2155) Tuberculosis HSPMDB001669 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-one CCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 47 ug/ml M. tuberculosis (H37Rv) Tuberculosis HSPMDB001670 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2 Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 28 ug/ml M. tuberculosis (H37Rv) Tuberculosis HSPMDB001671 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 3 Trans-4-butyl 3-heptyloxetan-2-one CCCCCCC[C@H]1[C@H](CCCC)OC1=O Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >800 ug/ml S. coelicolor Bacterial infection HSPMDB001672 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-one CCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >800 ug/ml S. coelicolor Bacterial infection HSPMDB001673 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2 Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >800 ug/ml S. coelicolor Bacterial infection HSPMDB001674 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 3 Trans-4-butyl 3-heptyloxetan-2-one CCCCCCC[C@H]1[C@H](CCCC)OC1=O Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 650 ug/ml S. griseus Bacterial infection HSPMDB001675 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-one CCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 580 ug/ml S. griseus Bacterial infection HSPMDB001676 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2 Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 250 ug/ml S. griseus Bacterial infection HSPMDB001677 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA 2.4 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001678 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA Ac-His-Lys-boroMet NA NA Boronate compounds NA NA 6.8 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001679 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA 2.1 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001680 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA 1.46 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001681 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA 0.96 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001682 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA 1.7 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001683 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA 4.2 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001684 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA 5.8 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001685 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.9 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001686 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA 2.4 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001687 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.75 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001688 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA 0.34 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001689 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA 0.4 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001690 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA 11.6 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001691 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA 0.46 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001692 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA Ac-His-Lys-boroMet NA NA Boronate compounds NA NA 0.78 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001693 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA 0.8 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001694 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA 3.2 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001695 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA 0.18 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001696 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA 0.24 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001697 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA 0.82 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001698 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA 0..34 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001699 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.23 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001700 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.18 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001701 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.0625 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001702 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA 0.29 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001703 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA 0.12 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001704 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA 13 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001705 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 12 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001706 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-His-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 6 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001707 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 3 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001708 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 12 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001709 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 3 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001710 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 3 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001711 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 24 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001712 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 6 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001713 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 3 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001714 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 6 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001715 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 7 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001716 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 12 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001717 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 13 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001718 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 200 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001719 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001720 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-His-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001721 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001722 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001723 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001724 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001725 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001726 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001727 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001728 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001729 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001730 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001731 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001732 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001733 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001734 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-His-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001735 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001736 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001737 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001738 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001739 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001740 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001741 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001742 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001743 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001744 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001745 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001746 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001747 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of protease activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA 0.14 NA NA NA NA Nucleotide binding domain Peptidase assay (Ac-PKM-amc) NA NA NA NA NA NA Tuberculosis HSPMDB001748 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of protease activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA 5.8 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Tuberculosis HSPMDB001749 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of protease activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA 3.2 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Tuberculosis HSPMDB001750 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 6.99 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001751 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA AV176 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 1.54 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001752 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA TG42 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 0.39 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001753 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA TG43 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 0.57 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001754 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA TG53 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 0.33 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001755 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA TG54 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 1.49 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001756 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 4.01 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001757 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 1.44 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001758 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA TG42 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001759 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA TG43 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001760 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA TG53 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001761 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA TG54 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 2.74 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001762 24022489 Hsp100 ClpC1 Bacteria Cytosol Binding affinity NA CymA1 (3S,6S,9S,12S,15S,18S,21S)-3-[(R)-[1-[(3S)-4-(3-aminopropylamino)-3-hydroxy-2-methylbutan-2-yl]indol-3-yl]-hydroxymethyl]-21-[(2R)-3-hydroxy-2-methylpropyl]-15-[(R)-methoxy(phenyl)methyl]-1,10,18-trimethyl-6-[(2R)-4-methylpent-3-en-2-yl]-9-(2-methylpropyl)-12-propan-2-yl-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptone CC1C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)CO)C)C(C2=CN(C3=CC=CC=C32)C(C)(C)C(CNCCCN)O)O)C(C)C=C(C)C)CC(C)C)C)C(C)C)C(C4=CC=CC=C4)OC Cyclomarine A (CymA) derivative NA 0.012 NA NA NA NA NA NA NA Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Tuberculosis HSPMDB001763 24022489 Hsp100 ClpC1 Bacteria Cytosol NA Antibacterial activity CymA1 (3S,6S,9S,12S,15S,18S,21S)-3-[(R)-[1-[(3S)-4-(3-aminopropylamino)-3-hydroxy-2-methylbutan-2-yl]indol-3-yl]-hydroxymethyl]-21-[(2R)-3-hydroxy-2-methylpropyl]-15-[(R)-methoxy(phenyl)methyl]-1,10,18-trimethyl-6-[(2R)-4-methylpent-3-en-2-yl]-9-(2-methylpropyl)-12-propan-2-yl-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptone CC1C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)CO)C)C(C2=CN(C3=CC=CC=C32)C(C)(C)C(CNCCCN)O)O)C(C)C=C(C)C)CC(C)C)C)C(C)C)C(C4=CC=CC=C4)OC Cyclomarine A (CymA) derivative NA NA NA NA NA NA NA NA NA NA 50% Bacterial growth inhibition assay (OD based) NA NA 1.2 uM M. smegmatis (mc2155) Tuberculosis HSPMDB001764 24022489 Hsp100 ClpC1 Bacteria Cytosol NA Antibacterial activity CymA1 (3S,6S,9S,12S,15S,18S,21S)-3-[(R)-[1-[(3S)-4-(3-aminopropylamino)-3-hydroxy-2-methylbutan-2-yl]indol-3-yl]-hydroxymethyl]-21-[(2R)-3-hydroxy-2-methylpropyl]-15-[(R)-methoxy(phenyl)methyl]-1,10,18-trimethyl-6-[(2R)-4-methylpent-3-en-2-yl]-9-(2-methylpropyl)-12-propan-2-yl-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptone CC1C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)CO)C)C(C2=CN(C3=CC=CC=C32)C(C)(C)C(CNCCCN)O)O)C(C)C=C(C)C)CC(C)C)C)C(C)C)C(C4=CC=CC=C4)OC Cyclomarine A (CymA) derivative NA NA NA NA NA NA NA NA NA NA 50% Bacterial growth inhibition assay (OD based) NA NA 0.28 uM M. bovis Tuberculosis HSPMDB001765 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 10 Benzyl (1-(Diphenoxyphosphoryl)-2-phenylethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=CC=C4 Serine protease inhibitor library 7% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001766 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 11 Benzyl (1-(Diphenoxyphosphoryl)-2-(p-tolyl)ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(C)C=C4 Serine protease inhibitor library 7% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001767 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 12 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-methoxyphenyl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(OC)C=C4 Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001768 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 13 Benzyl (Benzofuran-5-yl(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3OC=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 6% at 200uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001769 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 14 Benzyl (1-(Diphenoxyphosphoryl)-2-(naphthalen-2-yl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C5C=CC=CC5=C4 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001770 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 15 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-fluorophenyl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(F)C=C4 Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001771 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 16 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamate O=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library 100% at 200 uM NA NA 14.2 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001772 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 17 Benzyl (1-(Diphenoxyphosphoryl)-3-(methylthio)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCSC Serine protease inhibitor library 9% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001773 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 18 Benzyl ((Diphenoxyphosphoryl)(6-hydroxynaphthalen-2-yl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C5C=C(O)C=CC5=C4 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001774 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 21 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-hydroxyphenyl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001775 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 22 Benzyl (1-(Diphenoxyphosphoryl)-2-(3-hydroxyphenyl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=CC(O)=C4 Serine protease inhibitor library 3% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001776 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 23 Benzyl (1-((4-Acetamidobenzyl)(4-acetamidophenoxy)-phosphoryl)-2-phenylethyl)carbamate O=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(CC2=CC=C(NC(C)=O)C=C2)=O)CC3=CC=CC=C3)NCC4=CC=CC=C4 Serine protease inhibitor library 9% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001777 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 Benzyl (1-(Hydroxy(phenoxy)phosphoryl)-2-(4-hydroxyphenyl)-ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(O)=O)CC3=CC=C(O)C=C3 Serine protease inhibitor library 11% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001778 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 25 Benzyl (2-(4-Hydroxyphenyl)-1-(methoxy(phenoxy)phosphoryl)-ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC)=O)CC3=CC=C(O)C=C3 Serine protease inhibitor library 14% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001779 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 Benzyl (S)-(1-Cyano-2-(4-hydroxyphenyl)ethyl)carbamate O=C(OCC1=CC=CC=C1)N[C@H](C#N)CC2=CC=C(O)C=C2 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001780 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 Benzyl (S)-(1-Cyano-2-phenylethyl)carbamate O=C(OCC1=CC=CC=C1)N[C@H](C#N)CC2=CC=CC=C2 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001781 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 Benzyl ((2S)-1-((1-(Diphenoxyphosphoryl)-2-(4-hydroxyphenyl)-ethyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4)=O Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001782 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 36 Benzyl ((2S)-6-Amino-1-((1-(diphenoxyphosphoryl)-3-(methylthio)propyl)amino)-1-oxohexan-2-yl)carbamate Hydrochloride O=C(OCC1=CC=CC=C1)N[C@@H](CCCCN)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCSC)=O.[H]Cl Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001783 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 41 Benzyl ((S)-1-(((S)-1-Cyano-2-(4-hydroxyphenyl)ethyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@H](C#N)CC2=CC=C(O)C=C2)=O Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001784 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 42 Diphenyl ((1-Carbamimidoy l p i p e r i d i n - 4 - y l ) ( 2 - ( 4 -methoxyphenyl)acetamido)methyl)phosphonate 2,2,2-trifluoroacetate O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)CC4=CC=C(OC)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001785 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 43 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(nicotinamido)-methyl)phosphonate 2,2,2-trifluoroacetate O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)C4=CN=CC=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001786 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 44 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(furan-2-carboxamido)methyl)phosphonate 2,2,2-trifluoroacetate O=C(C1=CC=CO1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4CCN(C(N)=N)CC4.O=C(O)C(F)(F)F Serine protease inhibitor library 24% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001787 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 45 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(cinnamamido)-methyl)phosphonate Bis(2,2,2-trifluoroacetate) O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)/C=C/C4=CC=CC=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F Serine protease inhibitor library 18% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001788 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 46 D i p h e n y l ( ( 1 - C a rbami m i d o y l p i p e r i d i n - 4 - y l ) ( 2 -phenoxyethylsulfonamido)methyl)phosphonate 2,2,2-trifluoroacetate O=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)(CCOC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 27% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001789 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 47 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(3-(piperidin-4-yl)-propanamido)methyl)phosphonate bis(2,2,2-trifluoroacetate) O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)CCC4CCNCC4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001790 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 48 Diphenyl (E)-Diphenyl ((3-(Benzo[d][1,3]dioxol-5-yl)acrylamido)-(1-carbamimidoylpiperidin-4-yl)methyl)phosphonate 2,2,2-Trifluoroacetate NC(N1CCC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC(/C=C/C4=CC=C(OCO5)C5=C4)=O)CC1)=N.O=C(O)C(F)(F)F Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001791 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 49 Diphenyl ((3-(Benzo[d][1,3]dioxol-5-yl)propiolamido)(1-carbamimidoylpiperidin-4-yl)methyl)phosphonate NC(N1CCC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC(C#CC4=CC=C(OCO5)C5=C4)=O)CC1)=N Serine protease inhibitor library 24% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001792 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 50 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)((5-phenylpyrimidin-2-yl)amino)methyl)phosphonate 2,2,2-trifluoroacetate NC(N1CCC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC4=NC=C(C5=CC=CC=C5)C=N4)CC1)=N.O=C(O)C(F)(F)F Serine protease inhibitor library 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001793 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 51 (Z)-Diphenyl ((1-Carbamimidoylpiperidin - 4 - y l ) ( 3 -phenylacrylamido)methyl)phosphonate 2,2,2-Trifluoroacetate O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)/C=C\C4=CC=CC=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 11% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001794 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 52 Methyl (1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)-carbamate O=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3 Serine protease inhibitor library 27% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001795 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 53 Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonate C[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=O Serine protease inhibitor library 90% at 200 uM NA NA 49.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001796 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 54 P e n t - 4 - y n - 1 - y l ( 1 - ( d i p h e n o x y p h o s p h o r y l ) - 2 - ( 4 -guanidinophenyl)ethyl)carbamate O=C(OCCCC#C)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3 Serine protease inhibitor library 23% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001797 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 55 2-(2-Azidoethoxy)ethyl (1-(diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)carbamate O=C(OCCOCCN=[N+]=[N-])NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3 Serine protease inhibitor library 68% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001798 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 56 (Perfluorophenyl)methyl (1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)carbamate 2,2,2-Trifluoroacetate O=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4 Serine protease inhibitor library 25% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001799 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 57 3,3,4,4,5,5,6,6,7,8,8,8-Dodecafluoro-7-(trifluoromethyl)octyl 1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethylcarbamate2,2,2-Trifluoroacetate O=C(OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(C(F)(F)F)(F)C(F)(F)F)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3.O=C(O)C(F)(F)F Serine protease inhibitor library 55% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001800 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 58 Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 96% at 200 uM NA NA 39.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001801 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 59 2-Phenoxyethyl ((4-Aminophenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCCOC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001802 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 60 4,4,4-Trifluorobutyl ((4-Aminophenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCCCC(F)(F)F)NC(C1=CC=C(N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001803 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 61 ( P e r fl u o r o p h e n y l ) m e t h y l ( ( 4 - A m i n o p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 28% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001804 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 62 Diphenyl ((4-Guanidinophenyl)((4-(trifluoromethyl)phenyl)-sulfonamido)methyl)phosphonate O=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(N)=N)C=C3)(C4=CC=C(C(F)(F)F)C=C4)=O Serine protease inhibitor library 27% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001805 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 63 Diphenyl ((4-Guanidinophenyl)(phenylsulfonamido)methyl)-phosphonate O=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(N)=N)C=C3)(C4=CC=CC=C4)=O Serine protease inhibitor library 29% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001806 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 64 (Perfluorophenyl)methyl ((Diphenoxyphosphoryl)(4-guanidinophenyl)methyl)carbamate O=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(NC(N)=N)C=C4 Serine protease inhibitor library 48% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001807 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 65 Methyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)-phenyl)methyl)carbamate O=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(C(F)(F)F)=O)C=C3 Serine protease inhibitor library 64% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001808 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 66 Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5 Serine protease inhibitor library 93% at 200 uM NA NA 8.2 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001809 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 67 2-Ami n o e t h y l ((Diphenoxyphosph o r y l ) ( 4 - ( 2 , 2 , 2 -trifluoroacetamido)phenyl)methyl)carbamate 2,2,2-Trifluoroacetate O=C(OCCN)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(C(F)(F)F)=O)C=C3.O=C(O)C(F)(F)F Serine protease inhibitor library 73% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001810 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 68 B e n z y l 2 - ( 4 - ( 3 , 3 - D i m e t h y l u r e i d o ) p h e n y l ) - 1 -(diphenoxyphosphoryl)ethylcarbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N(C)C)=O)C=C4 Serine protease inhibitor library 9% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001811 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 69 Benzyl ((4-(2-Aminoethoxy)phenyl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(OCCN)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001812 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 70 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library 100% at 200 uM NA NA 13.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001813 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 71 Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library 93% at 200 uM NA NA 48.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001814 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 72 Methyl ((Diphenoxyphosphoryl)(5-nitronaphthalen-1-yl)-methyl)carbamate O=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=C4C=CC=C([N+]([O-])=O)C4=CC=C3 Serine protease inhibitor library 17% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001815 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 73 Diphenyl ((1-Carbamimidoylazetidin-3-yl)(pyrimidin-2-ylamino)methyl)phosphonate 2,2,2-trifluoroacetate NC(N1CC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC4=NC=CC=N4)C1)=N.O=C(O)C(F)(F)F Serine protease inhibitor library 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001816 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 74 Diphenyl ((3-(N-Hydroxycarbamimidoyl)phenyl)(pyrimidin-2-ylamino)methyl)phosphonate N=C(C1=CC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC4=NC=CC=N4)=CC=C1)NO Serine protease inhibitor library 23% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001817 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 75 2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethyl (Diphenoxyphosphoryl)(4-(piperazin-1-yl)phenyl)methylcarbamate 2,2,2-Trifluoroacetate O=C(O)C(F)(F)F.O=C(OCCOCCOCC#C)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(N4CCNCC4)C=C3 Serine protease inhibitor library 25% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001818 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 76 Benzyl (1-(Diphenoxyphosphoryl)-4-guanidinobutyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCCNC(N)=N Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001819 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 77 Benzyl (Benzo[d][1,3]dioxol-5-yl(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(OCO3)C3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001820 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 78 Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 100% at 200 uM NA NA 0.6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001821 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 79 Benzyl ((Diphenoxyphosphoryl)(pyridin-3-yl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=CN=C4 Serine protease inhibitor library 27% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001822 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 80 Benzyl ((Diphenoxyphosphoryl)(3-nitrophenyl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=CC([N+]([O-])=O)=C4 Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001823 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 81 Benzyl (1-(Diphenoxyphosphoryl)ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C Serine protease inhibitor library 3% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001824 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 82 Benzyl (1-(Diphenoxyphosphoryl)-3-methylbutyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC(C)C Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001825 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 83 Benzyl ((Diphenoxyphosphoryl)(4-guanidinophenyl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(NC(N)=N)C=C4 Serine protease inhibitor library 29% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001826 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 84 Benzyl (2-(Benzyloxy)-1-(diphenoxyphosphoryl)ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)COCC4=CC=CC=C4 Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001827 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 100% at 200 uM NA NA 0.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001828 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 86 Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4 Serine protease inhibitor library 100% at 200 uM NA NA 38 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001829 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 87 Benzyl ((2-Chloro-5-nitrophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC([N+]([O-])=O)=CC=C2Cl)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001830 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 88 Benzyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(C(N)=N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 30% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001831 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 89 Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 88% at 200 uM NA NA 100.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001832 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 81% at 200 uM NA NA 79.7 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001833 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 91 Benzyl ((Diphenoxyphosphoryl)(4-nitrophenyl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library 71% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001834 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 92 Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 100% at 200 uM NA NA 0.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001835 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 93 Benzyl (1-(Diphenoxyphosphoryl)-3-phenylpropyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=CC=C4 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001836 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 94 Benzyl ((Diphenoxyphosphoryl)(naphthalen-1-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=C5C=CC=CC5=CC=C4 Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001837 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 95 Benzyl ((Diphenoxyphosphoryl)(naphthalen-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C5C=CC=CC5=C4 Serine protease inhibitor library 51% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001838 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 96 Benzyl ((3-Cyanophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C#N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001839 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 97 B e n z y l ( ( 4 - ( D i m e t h y l a m i n o) n a p h t h a l e n - 1 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=C3C=CC=CC3=C(N(C)C)C=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001840 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 98 Benzyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)-phenyl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(NC(C(F)(F)F)=O)C=C4 Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001841 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 107 Benzyl ((Diphenoxyphosphoryl)(4-(piperazin-1-yl)phenyl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 100% at 200 uM NA NA 0.6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001842 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 108 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N3CCNCC3)C(C#N)=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 10% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001843 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 109 Benzyl ((Diphenoxyphosphoryl)(piperidin-4-yl)methyl)-carbamate 2,2,2-Trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4CCNCC4.O=C(O)C(F)(F)F Serine protease inhibitor library 30% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001844 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 110 Benzyl 1-(Diphenoxyphosphoryl)-2-(piperidin-4-yl)-ethylcarbamate 2,2,2-Trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4CCNCC4.O=C(O)C(F)(F)F Serine protease inhibitor library 16% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001845 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 111 Benzyl ((4-(Aminomethyl)cyclohexyl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-Trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CCC(CN)CC2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001846 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 114 Benzyl ((6-Aminonaphthalen-2-yl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001847 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 100% at 200 uM NA NA 71.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001848 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 116 Benzyl 2-(4-Acetamidophenyl)-1-(diphenoxyphosphoryl)-ethylcarbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(C)=O)C=C4 Serine protease inhibitor library 18% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001849 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 117 Benzyl ((Diphenoxyphosphoryl)(5-nitronaphthalen-1-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=C5C=CC=C([N+]([O-])=O)C5=CC=C4 Serine protease inhibitor library 49% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001850 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 118 B e n z y l ( ( 4 - ( D i m e t h y l a m i n o ) - 3 - n i t r o p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C([N+]([O-])=O)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 39% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001851 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 120 Benzyl (3-(4-Aminophenyl)-1-(diphenoxyphosphoryl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C(N)C=C4 Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001852 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 121 B e n z y l ( ( 3 - A m i n o - 4 - ( d i m e t h y l a m i n o ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 22% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001853 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 122 Benzyl ((4-Acetamidophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(NC(C)=O)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 8% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001854 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 123 Benzyl ((4-(3,3-Dimethylureido)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(NC(N(C)C)=O)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 22% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001855 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 124 Benzyl ((Diphenoxyphosphoryl)(3-guanidinophenyl)methyl)-carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=CC(NC(N)=N)=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001856 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 125 Benzyl ((Diphenoxyphosphoryl)(5-guanidinonaphthalen-1-yl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=C5C=CC=C(NC(N)=N)C5=CC=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 38% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001857 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 126 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-(methylsulfonamido)-phenyl)propyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C(NS(=O)(C)=O)C=C4 Serine protease inhibitor library 10% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001858 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 127 Benzyl ((4-(Dimethylamino)-3-(methylsulfonamido)phenyl)-(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C(NS(=O)(C)=O)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 46% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001859 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 128 Methyl ((Diphenoxyphosphoryl)(3-(trifluoromethyl)phenyl)-methyl)carbamate O=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=CC(C(F)(F)F)=C3 Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001860 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 129 Benzyl (1-(Bis(4-acetamidophenoxy)phosphoryl)-2-(4-(trifluoromethyl)phenyl)ethyl)carbamate O=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library 1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001861 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 130 Methyl (1-(Bis(4-acetamidophenoxy)phosphoryl)-2-(4-(trifluoromethyl)phenyl)ethyl)carbamate O=C(OC)NC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)CC3=CC=C(C(F)(F)F)C=C3 Serine protease inhibitor library 20% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001862 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 135 Methyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OC)NC(C1=CC=CC(N)=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library 7% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001863 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 136 Benzo[d][1,3]dioxol-5-ylmethyl ((3-Aminophenyl)-(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(C3=CC=CC(N)=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 20% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001864 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 137 Benzyl ((3-Aminophenyl)(bis(4-acetamidophenoxy)phosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=C(NC(C)=O)C=C3)(OC4=CC=C(NC(C)=O)C=C4)=O Serine protease inhibitor library 21% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001865 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 138 Methyl ((3-Aminophenyl)(bis(4-acetamidophenoxy)phosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=CC(N)=C1)P(OC2=CC=C(NC(C)=O)C=C2)(OC3=CC=C(NC(C)=O)C=C3)=O Serine protease inhibitor library 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001866 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 145 Methyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=CC(C(N)=N)=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library 30% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001867 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 146 Benzyl ( ( B is(4-acetamidophenoxy)phosphoryl)( 3-carbamimidoylphenyl)methyl)carbamate O=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)C3=CC=CC(C(N)=N)=C3)NCC4=CC=CC=C4 Serine protease inhibitor library 29% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001868 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 147 Methyl ((Bis(4-acetamidophenoxy)phosphoryl)(3-carbamimidoylphenyl)methyl)carbamate O=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)C3=CC=CC(C(N)=N)=C3)NC Serine protease inhibitor library 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001869 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 151 (S)-Benzyl ((3-Aminophenyl)(cyano)methyl)carbamate O=C(OCC1=CC=CC=C1)N[C@@H](C2=CC=CC(N)=C2)C#N Serine protease inhibitor library 8% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001870 30571121 Hsp100 NA Human NA NA Antiproliferative activity 16 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamate O=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001871 30571121 Hsp100 NA Human NA NA Antiproliferative activity 53 Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonate C[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001872 30571121 Hsp100 NA Human NA NA Antiproliferative activity 58 Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001873 30571121 Hsp100 NA Human NA NA Antiproliferative activity 66 Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001874 30571121 Hsp100 NA Human NA NA Antiproliferative activity 70 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001875 30571121 Hsp100 NA Human NA NA Antiproliferative activity 71 Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001876 30571121 Hsp100 NA Human NA NA Antiproliferative activity 78 Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001877 30571121 Hsp100 NA Human NA NA Antiproliferative activity 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001878 30571121 Hsp100 NA Human NA NA Antiproliferative activity 86 Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001879 30571121 Hsp100 NA Human NA NA Antiproliferative activity 89 Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 19.9 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001880 30571121 Hsp100 NA Human NA NA Antiproliferative activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 19.9 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001881 30571121 Hsp100 NA Human NA NA Antiproliferative activity 92 Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001882 30571121 Hsp100 NA Human NA NA Antiproliferative activity 107 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 8.6 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001883 30571121 Hsp100 NA Human NA NA Antiproliferative activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001884 30571121 Hsp100 NA Human NA NA Antiproliferative activity 16 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamate O=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001885 30571121 Hsp100 NA Human NA NA Antiproliferative activity 53 Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonate C[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001886 30571121 Hsp100 NA Human NA NA Antiproliferative activity 58 Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001887 30571121 Hsp100 NA Human NA NA Antiproliferative activity 66 Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001888 30571121 Hsp100 NA Human NA NA Antiproliferative activity 70 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001889 30571121 Hsp100 NA Human NA NA Antiproliferative activity 71 Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001890 30571121 Hsp100 NA Human NA NA Antiproliferative activity 78 Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 28.4 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001891 30571121 Hsp100 NA Human NA NA Antiproliferative activity 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 23.8 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001892 30571121 Hsp100 NA Human NA NA Antiproliferative activity 86 Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001893 30571121 Hsp100 NA Human NA NA Antiproliferative activity 89 Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 10.5 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001894 30571121 Hsp100 NA Human NA NA Antiproliferative activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 28.3 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001895 30571121 Hsp100 NA Human NA NA Antiproliferative activity 92 Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001896 30571121 Hsp100 NA Human NA NA Antiproliferative activity 107 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 1.1 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001897 30571121 Hsp100 NA Human NA NA Antiproliferative activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001898 30571121 Hsp100 NA Human NA NA Antiproliferative activity 16 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamate O=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001899 30571121 Hsp100 NA Human NA NA Antiproliferative activity 53 Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonate C[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001900 30571121 Hsp100 NA Human NA NA Antiproliferative activity 58 Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 57.8 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001901 30571121 Hsp100 NA Human NA NA Antiproliferative activity 66 Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5 Serine protease inhibitor library NA NA NA NA 41.5 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001902 30571121 Hsp100 NA Human NA NA Antiproliferative activity 70 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001903 30571121 Hsp100 NA Human NA NA Antiproliferative activity 71 Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001904 30571121 Hsp100 NA Human NA NA Antiproliferative activity 78 Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 65.6 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001905 30571121 Hsp100 NA Human NA NA Antiproliferative activity 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 27.5 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001906 30571121 Hsp100 NA Human NA NA Antiproliferative activity 86 Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001907 30571121 Hsp100 NA Human NA NA Antiproliferative activity 89 Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 5.9 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001908 30571121 Hsp100 NA Human NA NA Antiproliferative activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 25.6 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001909 30571121 Hsp100 NA Human NA NA Antiproliferative activity 92 Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001910 30571121 Hsp100 NA Human NA NA Antiproliferative activity 107 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 0.4 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001911 30571121 Hsp100 NA Human NA NA Antiproliferative activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001912 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 99.90% Bacterial growth inhibition assay (OD based) NA NA NA S. aureus (ATCC 29213) Bacterial infection HSPMDB001913 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 98.90% Bacterial growth inhibition assay (OD based) NA NA NA E. coli tolC deleted (JW5503) Bacterial infection HSPMDB001914 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 107 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 69.90% Bacterial growth inhibition assay (OD based) NA NA NA E. coli tolC deleted (JW5503) Bacterial infection HSPMDB001915 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 99% Bacterial growth inhibition assay (OD based) NA NA NA E. coli tolC deleted (JW5503) Bacterial infection HSPMDB001916 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 98.50% Bacterial growth inhibition assay (OD based) NA NA NA E. coli (BW25113) + PAbetaN Bacterial infection HSPMDB001917 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 99.40% Bacterial growth inhibition assay (OD based) NA NA NA E. coli clpP deleted (JW0427-1) + PAbetaN Bacterial infection HSPMDB001918 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA NA E. coli (BW25113) + DPTA NONOate Bacterial infection HSPMDB001919 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID16472035/CID676352 2-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochloride Cl.C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001920 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-150/CID886813 2-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochloride Cl.C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001921 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD03665 (10E)-10-(hydroxymethylidene)-9,10-dihydrophenanthren-9-one O\C=C1\C(=O)C2=C(C=CC=C2)C2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001922 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-127/CID6763 phenanthrene-9,10-dione C1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001923 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD02342 1-(4-Methylphenyl)-3-phenyl-2-propyn-1-one CC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 47 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001924 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID934321 2-chloro-1-(1-methylindol-3-yl)ethanone CN1C=C(C2=CC=CC=C21)C(=O)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001925 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA S09756 9-[(E)-2-nitroethenyl]anthracene [O-][N+](=O)\C=C\C1=C2C=CC=CC2=CC2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.28 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001926 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD00597 3-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-one O1C(=NC2=C1C=CC=C2)SC2=CC(CC(C2)(C)C)=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001927 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SEW05182 5-({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione CC1(C)OC(=O)C(=CC2=CC=C(O2)C2=C(Cl)C=CC(=C2)C(F)(F)F)C(=O)O1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 10 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001928 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1109468 5-amino-4-cyano-N-[(2-methoxynaphthalen-1-yl)methylideneamino]-3-methylthiophene-2-carboxamide CC1=C(SC(=C1C#N)N)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.6 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001929 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-132/CID2939678 2-[1-hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acid C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CC(=C3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001930 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-130/CID9586497 2-[(E)-[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]guanidine C1=CC(=CC=C1C=NN=C(N)N)OCC2=C(C=C(C=C2)Cl)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 51 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001931 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-204/CID3500086 2-(5-chloro-1-ethyl-3-nitro-6-oxopyridazin-4-yl)-2-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetonitrile CCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=C(S2)C=CC(=C3)C(F)(F)F)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 52 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001932 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5413643 2-[4-methyl-6-(phenylamino)pyrimidin-2-yl]phenol CC1=CC(NC2=CC=CC=C2)=NC(=N1)C1=C(O)C=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 53 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001933 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-131/CID2867539/CID/9567210 3-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-6-phenyl-4H-1,2,4-triazin-5-one COC1=CC=C(C=C1)C=NNC2=NN=C(C(=O)N2)C3=CC=CC=C3 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 54 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001934 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-128/CID987585 N-(1-benzyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamide C1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NC(=O)C5=CC=CC=C5Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 55 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001935 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID6524677 (4Z)-4-[[2-(7-chloroquinolin-4-yl)hydrazinyl]methylidene]-2-hydroxycyclohexa-2,5-dien-1-one C1=CC2=C(C=CN=C2C=C1Cl)NNC=C3C=CC(=O)C(=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 36 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001936 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SPB01017 [1-(1,3-dithiolan-2-yl)naphthalen-2-yl] thiophene-2-carboxylate C1CSC(S1)C2=C(C=CC3=CC=CC=C32)OC(=O)C4=CC=CS4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001937 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA HTS01888 N-[4-(3-Chloro-4-methylphenyl)-5-methyl-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole-4-sulfonamide Cc1ccc(cc1Cl)c2nc(NS(=O)(=O)c3cccc4nonc34)sc2C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 14.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001938 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-129/CID801956 methyl 2-[(2-methylbenzoyl)carbamothioylamino]benzoate CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=CC=C2C(=O)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001939 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5756550 (5Z)-5-[(2-phenyl-1H-indol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C=C4C(=O)NC(=S)S4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001940 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD07581 6-[(2-chlorophenyl)amino]-2-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile ClC1=CC=CC=C1NC1=C(C#N)C(=O)NC(S1)C1=C(Cl)C=CC=C1Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 5.9 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001941 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD02660 methyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylate [H]COC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001942 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SP01086 3-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazole CSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 25 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001943 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID3598 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 5.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001944 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2884885 2,2-dichloro-N-(4-fluorophenyl)-3-phenylcyclopropane-1-carboxamide C1=CC=C(C=C1)C2C(C2(Cl)Cl)C(=O)NC3=CC=C(C=C3)F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001945 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID409928 2-[3-(dibutylamino)propyl]isoindole-1,3-dione CCCCN(CCCC)CCCN1C(=O)C2=CC=CC=C2C1=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001946 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5875182 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4SC)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 22 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001947 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID16194309 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-(2-methylpropylsulfonyl)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4S(=O)(=O)CC(C)C)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 12 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001948 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5691857 2-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-one COC1=CC=CC(=C1)N2C(=O)C3=CC=CC=C3N=C2SCC4=CC(=O)OC5=CC(=C(C=C45)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 21 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001949 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-1206/CID2384538 2-(chloromethyl)-1H-pyrimido[1,2-a]benzimidazol-4-one C1=CC=C2C(=C1)N=C3N2C(=O)C=C(N3)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001950 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-202/CID2810445 2,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide C1=CC=C2C(=C1)C(=O)C(C2=O)(NC(=O)C3=C(C=CC=C3Cl)Cl)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001951 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2175556 4-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]benzenesulfonamide C1=CC(=CC=C1NC2=NC(=CS2)C3=C(C=C(C=C3)O)O)S(=O)(=O)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 24 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001952 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-201/CID2810155 2-methyl-N-(7-methyl-4-oxothieno[3,2-d][1,3]thiazin-2-yl)benzamide CC1=CC=CC=C1C(=O)NC2=NC3=C(C(=O)S2)SC=C3C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001953 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-209/CID2472581 [2-(1H-indol-3-yl)-2-oxoethyl] 5-nitrothiophene-2-carboxylate C1=CC=C2C(=C1)C(=CN2)C(=O)COC(=O)C3=CC=C(S3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 51 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001954 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-199/CID4072379 N'-acridin-9-yl-2,4-dihydroxybenzohydrazide C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NNC(=O)C4=C(C=C(C=C4)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 52 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001955 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1625680 4-[5-[(Z)-2-carboxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethenyl]furan-2-yl]-2-chlorobenzoic acid CC1=NC(=NN1)SC(=CC2=CC=C(O2)C3=CC(=C(C=C3)C(=O)O)Cl)C(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 53 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001956 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KM08995 3-(5-acetylthiophen-2-yl)prop-2-ynyl N-phenylcarbamate CC(=O)C1=CC=C(S1)C#CCOC(=O)NC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 7.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001957 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1976446 (6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-2-pyridin-4-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one C1=CC=C2C(=C1)C(=O)C(=CO2)C=C3C(=N)N4C(=NC3=O)SC(=N4)C5=CC=NC=C5 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 11 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001958 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID930238 7-propan-2-yl-10-thia-8,13,15-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1,6,8,11(16),13-pentaene-12-thione CC(C)C1=C2CCCC2=C3C4=C(C(=S)N=CN4)SC3=N1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 42 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001959 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2978460 4-[[4-(2-fluorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]sulfonylamino]benzoic acid C1C=CC2C1C(NC3=C2C=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 19 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001960 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD00823 3-(1H-indol-3-ylmethylidene)indolin-2-one O=c1nc2ccccc2c1=Cc1cnc2ccccc21 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001961 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD01560 4-pyren-1-ylbutanoic acid C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCCC(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 10 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001962 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-133/CID5559718 (Z)-2-(1,3-benzothiazol-2-yl)-3-hydroxy-4-(4-methylphenyl)sulfanylbut-2-enenitrile CC1=CC=C(C=C1)SCC(=C(C#N)C2=NC3=CC=CC=C3S2)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001963 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-205/CID5982653 3-nitro-4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinyl]benzenesulfonamide C1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])NN=CC2=C(C(=C(C=C2)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001964 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-232/CID3787408 N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-4-methylbenzenesulfonamide CCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)S(=O)(=O)C4=CC=CC=C4)NS(=O)(=O)C5=CC=C(C=C5)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001965 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-233/CID2044030 N-(1-benzylpyrrolo[3,2-b]quinoxalin-2-yl)-4-chlorobenzenesulfonamide C1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=C(C=C5)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001966 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD02506 3-{bicyclo[2.2.1]hept-5-en-2-yl}-1-{[(4-bromo-3-chlorophenyl)carbamothioyl]amino}thiourea ClC1=CC(NC(=S)NNC(=S)NC2CC3CC2C=C3)=CC=C1Br Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001967 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD06082 N-{[(2,5-dichlorophenyl)carbamothioyl]amino}-2-{[(E)-[(2,4-dichlorophenyl)methylidene]amino]oxy}acetamide ClC1=CC(Cl)=C(\C=N\OCC(=O)NNC(=S)NC2=C(Cl)C=CC(Cl)=C2)C=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001968 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID160115 5,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-one CC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 44 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001969 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID16472035/CID676352 2-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochloride C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4.Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001970 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-150/CID886813 N-benzyl-2-(2-fluorophenyl)quinazolin-4-amine Fc1ccccc1c2nc(NCc3ccccc3)c4ccccc4n2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001971 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD03665 (10E)-10-(hydroxymethylidene)-9,10-dihydrophenanthren-9-one O\C=C1\C(=O)C2=C(C=CC=C2)C2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.26 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001972 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-127/CID6763 phenanthrene-9,10-dione C1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001973 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD02342 1-(4-Methylphenyl)-3-phenyl-2-propyn-1-one CC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001974 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID934321 2-chloro-1-(1-methylindol-3-yl)ethanone CN1C=C(C2=CC=CC=C21)C(=O)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.3 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001975 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA S09756 9-[(E)-2-nitroethenyl]anthracene [O-][N+](=O)\C=C\C1=C2C=CC=CC2=CC2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.8 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001976 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD00597 3-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-one O1C(=NC2=C1C=CC=C2)SC2=CC(CC(C2)(C)C)=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 6.1 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001977 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SEW05182 5-({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione CC1(C)OC(=O)C(=CC2=CC=C(O2)C2=C(Cl)C=CC(=C2)C(F)(F)F)C(=O)O1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 13 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001978 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1109468 5-amino-4-cyano-N-[(2-methoxynaphthalen-1-yl)methylideneamino]-3-methylthiophene-2-carboxamide CC1=C(SC(=C1C#N)N)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001979 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-132/CID2939678 2-[1-hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acid C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CC(=C3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 24 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001980 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-130/CID9586497 2-[(E)-[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]guanidine C1=CC(=CC=C1C=NN=C(N)N)OCC2=C(C=C(C=C2)Cl)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 24 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001981 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-204/CID3500086 2-(5-chloro-1-ethyl-3-nitro-6-oxopyridazin-4-yl)-2-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetonitrile CCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=C(S2)C=CC(=C3)C(F)(F)F)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 14 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001982 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5413643 2-[4-methyl-6-(phenylamino)pyrimidin-2-yl]phenol CC1=CC(NC2=CC=CC=C2)=NC(=N1)C1=C(O)C=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 10 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001983 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-131/CID2867539/CID/9567210 3-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-6-phenyl-4H-1,2,4-triazin-5-one COC1=CC=C(C=C1)C=NNC2=NN=C(C(=O)N2)C3=CC=CC=C3 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001984 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-128/CID987585 N-(1-benzyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamide C1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NC(=O)C5=CC=CC=C5Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 147 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001985 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID6524677 (4Z)-4-[[2-(7-chloroquinolin-4-yl)hydrazinyl]methylidene]-2-hydroxycyclohexa-2,5-dien-1-one C1=CC2=C(C=CN=C2C=C1Cl)NNC=C3C=CC(=O)C(=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 4.9 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001986 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SPB01017 [1-(1,3-dithiolan-2-yl)naphthalen-2-yl] thiophene-2-carboxylate C1CSC(S1)C2=C(C=CC3=CC=CC=C32)OC(=O)C4=CC=CS4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 6.4 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001987 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA HTS01888 N-[4-(3-Chloro-4-methylphenyl)-5-methyl-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole-4-sulfonamide Cc1ccc(cc1Cl)c2nc(NS(=O)(=O)c3cccc4nonc34)sc2C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 19 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001988 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-129/CID801956 methyl 2-[(2-methylbenzoyl)carbamothioylamino]benzoate CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=CC=C2C(=O)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.1 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001989 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5756550 (5Z)-5-[(2-phenyl-1H-indol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C=C4C(=O)NC(=S)S4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 34 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001990 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD07581 6-[(2-chlorophenyl)amino]-2-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile ClC1=CC=CC=C1NC1=C(C#N)C(=O)NC(S1)C1=C(Cl)C=CC=C1Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 4 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001991 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD02660 ethyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylate CCOC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001992 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SP01086 3-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazole CSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001993 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID3598 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.7 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001994 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2884885 2,2-dichloro-N-(4-fluorophenyl)-3-phenylcyclopropane-1-carboxamide C1=CC=C(C=C1)C2C(C2(Cl)Cl)C(=O)NC3=CC=C(C=C3)F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.15 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001995 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID409928 2-[3-(dibutylamino)propyl]isoindole-1,3-dione CCCCN(CCCC)CCCN1C(=O)C2=CC=CC=C2C1=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.6 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001996 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5875182 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4SC)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 8.3 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001997 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID16194309 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-(2-methylpropylsulfonyl)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4S(=O)(=O)CC(C)C)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 7.8 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001998 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5691857 2-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-one COC1=CC=CC(=C1)N2C(=O)C3=CC=CC=C3N=C2SCC4=CC(=O)OC5=CC(=C(C=C45)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 4.1 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001999 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-1206/CID2384538 2-(chloromethyl)-1H-pyrimido[1,2-a]benzimidazol-4-one C1=CC=C2C(=C1)N=C3N2C(=O)C=C(N3)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.9 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002000 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-202/CID2810445 2,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide C1=CC=C2C(=C1)C(=O)C(C2=O)(NC(=O)C3=C(C=CC=C3Cl)Cl)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002001 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2175556 4-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]benzenesulfonamide C1=CC(=CC=C1NC2=NC(=CS2)C3=C(C=C(C=C3)O)O)S(=O)(=O)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.7 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002002 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-201/CID2810155 2-methyl-N-(7-methyl-4-oxothieno[3,2-d][1,3]thiazin-2-yl)benzamide CC1=CC=CC=C1C(=O)NC2=NC3=C(C(=O)S2)SC=C3C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 104 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002003 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-209/CID2472581 [2-(1H-indol-3-yl)-2-oxoethyl] 5-nitrothiophene-2-carboxylate C1=CC=C2C(=C1)C(=CN2)C(=O)COC(=O)C3=CC=C(S3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 92 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002004 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-199/CID4072379 N'-acridin-9-yl-2,4-dihydroxybenzohydrazide C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NNC(=O)C4=C(C=C(C=C4)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 18 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002005 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1625680 4-[5-[(Z)-2-carboxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethenyl]furan-2-yl]-2-chlorobenzoic acid CC1=NC(=NN1)SC(=CC2=CC=C(O2)C3=CC(=C(C=C3)C(=O)O)Cl)C(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.85 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002006 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KM08995 3-(5-acetylthiophen-2-yl)prop-2-ynyl N-phenylcarbamate CC(=O)C1=CC=C(S1)C#CCOC(=O)NC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.4 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002007 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1976446 (6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-2-pyridin-4-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one C1=CC=C2C(=C1)C(=O)C(=CO2)C=C3C(=N)N4C(=NC3=O)SC(=N4)C5=CC=NC=C5 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.6 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002008 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID930238 7-propan-2-yl-10-thia-8,13,15-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1,6,8,11(16),13-pentaene-12-thione CC(C)C1=C2CCCC2=C3C4=C(C(=S)N=CN4)SC3=N1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 5.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002009 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2978460 4-[[4-(2-fluorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]sulfonylamino]benzoic acid C1C=CC2C1C(NC3=C2C=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 9 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002010 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD00823 3-(1H-indol-3-ylmethylidene)indolin-2-one O=c1nc2ccccc2c1=Cc1cnc2ccccc21 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 9.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002011 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD01560 4-pyren-1-ylbutanoic acid C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCCC(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 12 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002012 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-133/CID5559718 (Z)-2-(1,3-benzothiazol-2-yl)-3-hydroxy-4-(4-methylphenyl)sulfanylbut-2-enenitrile CC1=CC=C(C=C1)SCC(=C(C#N)C2=NC3=CC=CC=C3S2)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 8.8 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002013 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-205/CID5982653 3-nitro-4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinyl]benzenesulfonamide C1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])NN=CC2=C(C(=C(C=C2)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002014 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-232/CID3787408 N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-4-methylbenzenesulfonamide CCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)S(=O)(=O)C4=CC=CC=C4)NS(=O)(=O)C5=CC=C(C=C5)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002015 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-233/CID2044030 N-(1-benzylpyrrolo[3,2-b]quinoxalin-2-yl)-4-chlorobenzenesulfonamide C1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=C(C=C5)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 80 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002016 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD02506 3-{bicyclo[2.2.1]hept-5-en-2-yl}-1-{[(4-bromo-3-chlorophenyl)carbamothioyl]amino}thiourea ClC1=CC(NC(=S)NNC(=S)NC2CC3CC2C=C3)=CC=C1Br Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002017 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD06082 N-{[(2,5-dichlorophenyl)carbamothioyl]amino}-2-{[(E)-[(2,4-dichlorophenyl)methylidene]amino]oxy}acetamide ClC1=CC(Cl)=C(\C=N\OCC(=O)NNC(=S)NC2=C(Cl)C=CC(Cl)=C2)C=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 20 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002018 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID160115 5,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-one CC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002019 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA Eeyarestatin I (Eerl) 2-[3-(4-chlorophenyl)-4-[(4-chlorophenyl)carbamoyl-hydroxyamino]-5,5-dimethyl-2-oxoimidazolidin-1-yl]-N-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]acetamide CC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002020 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA Myriad 19/KSC-1-275 4-[(4-phenyl-1,3-thiazol-2-yl)amino]phenol C1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=C(C=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 21 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002021 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA Myriad 12/KSC-1-277 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 20 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002022 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-16-5 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]imino]cyclohexa-2,5-dien-1-one C1=CC(=O)C=CC1=NC2=NC(=CS2)C3=CC=C(C=C3)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 68 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002023 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID16472035/CID676352 2-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochloride C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4.Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.6 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002024 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-150/CID886813 N-benzyl-2-(2-fluorophenyl)quinazolin-4-amine Fc1ccccc1c2nc(NCc3ccccc3)c4ccccc4n2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 9 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002025 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity JFD03665 (10E)-10-(hydroxymethylidene)-9,10-dihydrophenanthren-9-one O\C=C1\C(=O)C2=C(C=CC=C2)C2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.1 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002026 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-127/CID6763 phenanthrene-9,10-dione C1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.3 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002027 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity JFD02342 1-(4-Methylphenyl)-3-phenyl-2-propyn-1-one CC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.4 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002028 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID934321 2-chloro-1-(1-methylindol-3-yl)ethanone CN1C=C(C2=CC=CC=C21)C(=O)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.6 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002029 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity S09756 9-[(E)-2-nitroethenyl]anthracene [O-][N+](=O)\C=C\C1=C2C=CC=CC2=CC2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 5 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002030 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity JFD00597 3-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-one O1C(=NC2=C1C=CC=C2)SC2=CC(CC(C2)(C)C)=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 6.6 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002031 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity SEW05182 5-({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione CC1(C)OC(=O)C(=CC2=CC=C(O2)C2=C(Cl)C=CC(=C2)C(F)(F)F)C(=O)O1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 7.5 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002032 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID1109468 5-amino-4-cyano-N-[(2-methoxynaphthalen-1-yl)methylideneamino]-3-methylthiophene-2-carboxamide CC1=C(SC(=C1C#N)N)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 10 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002033 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-132/CID2939678 2-[1-hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acid C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CC(=C3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 8.4 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002034 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-130/CID9586497 2-[(E)-[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]guanidine C1=CC(=CC=C1C=NN=C(N)N)OCC2=C(C=C(C=C2)Cl)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 11 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002035 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-204/cid3500086 2-(5-chloro-1-ethyl-3-nitro-6-oxopyridazin-4-yl)-2-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetonitrile CCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=C(S2)C=CC(=C3)C(F)(F)F)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 13 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002036 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID5413643 2-[4-methyl-6-(phenylamino)pyrimidin-2-yl]phenol CC1=CC(NC2=CC=CC=C2)=NC(=N1)C1=C(O)C=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 16 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002037 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-131/CID2867539/CID/9567210 3-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-6-phenyl-4H-1,2,4-triazin-5-one COC1=CC=C(C=C1)C=NNC2=NN=C(C(=O)N2)C3=CC=CC=C3 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 16 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002038 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-128/CID987585 N-(1-benzyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamide C1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NC(=O)C5=CC=CC=C5Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 17 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002039 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID6524677 (4Z)-4-[[2-(7-chloroquinolin-4-yl)hydrazinyl]methylidene]-2-hydroxycyclohexa-2,5-dien-1-one C1=CC2=C(C=CN=C2C=C1Cl)NNC=C3C=CC(=O)C(=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 15 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002040 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity SPB01017 [1-(1,3-dithiolan-2-yl)naphthalen-2-yl] thiophene-2-carboxylate C1CSC(S1)C2=C(C=CC3=CC=CC=C32)OC(=O)C4=CC=CS4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 19 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002041 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity HTS01888 N-[4-(3-Chloro-4-methylphenyl)-5-methyl-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole-4-sulfonamide Cc1ccc(cc1Cl)c2nc(NS(=O)(=O)c3cccc4nonc34)sc2C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 19 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002042 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-129/CID801956 methyl 2-[(2-methylbenzoyl)carbamothioylamino]benzoate CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=CC=C2C(=O)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 21 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002043 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID5756550 (5Z)-5-[(2-phenyl-1H-indol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C=C4C(=O)NC(=S)S4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 22 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002044 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD07581 6-[(2-chlorophenyl)amino]-2-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile ClC1=CC=CC=C1NC1=C(C#N)C(=O)NC(S1)C1=C(Cl)C=CC=C1Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 23 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002045 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD02660 ethyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylate CCOC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 23 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002046 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity SP01086 3-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazole CSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 23 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002047 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID3598 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 27 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002048 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID2884885 2,2-dichloro-N-(4-fluorophenyl)-3-phenylcyclopropane-1-carboxamide C1=CC=C(C=C1)C2C(C2(Cl)Cl)C(=O)NC3=CC=C(C=C3)F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 27 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002049 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID409928 2-[3-(dibutylamino)propyl]isoindole-1,3-dione CCCCN(CCCC)CCCN1C(=O)C2=CC=CC=C2C1=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 36 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002050 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID5875182 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4SC)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 31 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002051 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID16194309 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-(2-methylpropylsulfonyl)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4S(=O)(=O)CC(C)C)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002052 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID5691857 2-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-one COC1=CC=CC(=C1)N2C(=O)C3=CC=CC=C3N=C2SCC4=CC(=O)OC5=CC(=C(C=C45)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 39 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002053 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-1206/CID2384538 2-(chloromethyl)-1H-pyrimido[1,2-a]benzimidazol-4-one C1=CC=C2C(=C1)N=C3N2C(=O)C=C(N3)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 38 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002054 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-202/CID2810445 2,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide C1=CC=C2C(=C1)C(=O)C(C2=O)(NC(=O)C3=C(C=CC=C3Cl)Cl)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 42 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002055 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID2175556 4-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]benzenesulfonamide C1=CC(=CC=C1NC2=NC(=CS2)C3=C(C=C(C=C3)O)O)S(=O)(=O)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 60 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002056 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-201/CID2810155 2-methyl-N-(7-methyl-4-oxothieno[3,2-d][1,3]thiazin-2-yl)benzamide CC1=CC=CC=C1C(=O)NC2=NC3=C(C(=O)S2)SC=C3C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 62 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002057 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-209/CID2472581 [2-(1H-indol-3-yl)-2-oxoethyl] 5-nitrothiophene-2-carboxylate C1=CC=C2C(=C1)C(=CN2)C(=O)COC(=O)C3=CC=C(S3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 66 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002058 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-199/CID4072379 N'-acridin-9-yl-2,4-dihydroxybenzohydrazide C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NNC(=O)C4=C(C=C(C=C4)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 68 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002059 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID1625680 4-[5-[(Z)-2-carboxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethenyl]furan-2-yl]-2-chlorobenzoic acid CC1=NC(=NN1)SC(=CC2=CC=C(O2)C3=CC(=C(C=C3)C(=O)O)Cl)C(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002060 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KM08995 3-(5-acetylthiophen-2-yl)prop-2-ynyl N-phenylcarbamate CC(=O)C1=CC=C(S1)C#CCOC(=O)NC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002061 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID1976446 (6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-2-pyridin-4-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one C1=CC=C2C(=C1)C(=O)C(=CO2)C=C3C(=N)N4C(=NC3=O)SC(=N4)C5=CC=NC=C5 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002062 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID930238 7-propan-2-yl-10-thia-8,13,15-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1,6,8,11(16),13-pentaene-12-thione CC(C)C1=C2CCCC2=C3C4=C(C(=S)N=CN4)SC3=N1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002063 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID2978460 4-[[4-(2-fluorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]sulfonylamino]benzoic acid C1C=CC2C1C(NC3=C2C=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002064 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD00823 3-(1H-indol-3-ylmethylidene)indolin-2-one O=c1nc2ccccc2c1=Cc1cnc2ccccc21 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002065 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity JFD01560 4-pyren-1-ylbutanoic acid C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCCC(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002066 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-133/CID5559718 (Z)-2-(1,3-benzothiazol-2-yl)-3-hydroxy-4-(4-methylphenyl)sulfanylbut-2-enenitrile CC1=CC=C(C=C1)SCC(=C(C#N)C2=NC3=CC=CC=C3S2)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002067 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-205/CID5982653 3-nitro-4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinyl]benzenesulfonamide C1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])NN=CC2=C(C(=C(C=C2)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002068 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-232/CID3787408 N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-4-methylbenzenesulfonamide CCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)S(=O)(=O)C4=CC=CC=C4)NS(=O)(=O)C5=CC=C(C=C5)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002069 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-233/CID2044030 N-(1-benzylpyrrolo[3,2-b]quinoxalin-2-yl)-4-chlorobenzenesulfonamide C1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=C(C=C5)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002070 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD02506 ethyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylate CCOC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002071 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD06082 3-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazole CSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002072 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID160115 5,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-one CC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002073 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity Eeyarestatin I (Eerl) 2-[3-(4-chlorophenyl)-4-[(4-chlorophenyl)carbamoyl-hydroxyamino]-5,5-dimethyl-2-oxoimidazolidin-1-yl]-N-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]acetamide CC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.7 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002074 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity Myriad 19/KSC-1-275 4-[(4-phenyl-1,3-thiazol-2-yl)amino]phenol C1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=C(C=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 26 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002075 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity Myriad 12/KSC-1-277 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 16 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002076 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-16-5 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]imino]cyclohexa-2,5-dien-1-one C1=CC(=O)C=CC1=NC2=NC(=CS2)C3=CC=C(C=C3)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 38 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002077 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity Mg132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 0.4 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA MRC-5 NA HSPMDB002078 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity Mg132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 0.2 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA HEK293 NA HSPMDB002079 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity Mg132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 1.5 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002080 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity Mg132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 0.14 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA RPMI8226 NA HSPMDB002081 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity DBeQ N2 , N4 -dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 6.6 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA MRC-5 NA HSPMDB002082 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity DBeQ N2 , N4 -dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 4 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA HEK293 NA HSPMDB002083 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity DBeQ N2 , N4 -dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 3.1 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002084 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity DBeQ N2 , N4 -dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 1.2 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA RPMI8226 NA HSPMDB002085 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor NA NA NA 6.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002086 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002087 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002088 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002089 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002090 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor NA NA NA 6.6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002091 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA Palmostatin M (3S,4S)-3-decyl-4-[4-[3-(dimethylamino)propylsulfonyl]butyl]oxetan-2-one CCCCCCCCCCC1C(OC1=O)CCCCS(=O)(=O)CCCN(C)C Non beta lactone inhibitor NA NA NA 21 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002092 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002093 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002094 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002095 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 75% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002096 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 70% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002097 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002098 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002099 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002100 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002101 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 45% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002102 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 85% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002103 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 40% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002104 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002105 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002106 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002107 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 80% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002108 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 40% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002109 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002110 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 30% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002111 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002112 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002113 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 25% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002114 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 25% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002115 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002116 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002117 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002118 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002119 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 60% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002120 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002121 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002122 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 98% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002123 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002124 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 98% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002125 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002126 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002127 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 45% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002128 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002129 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002130 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002131 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002132 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002133 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002134 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 80% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002135 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002136 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002137 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 75% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002138 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002139 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002140 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002141 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002142 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002143 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 99% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002144 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 88% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002145 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 99% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002146 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002147 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002148 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002149 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 88% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002150 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002151 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002152 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 80% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002153 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002154 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002155 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 88% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002156 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 65% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002157 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 25% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002158 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 60% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002159 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 40% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002160 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 45% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002161 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 80% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002162 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002163 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002164 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002165 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 25% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002166 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002167 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002168 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002169 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002170 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 40% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002171 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 45% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002172 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002173 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002174 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002175 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 10-15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002176 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002177 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002178 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 50% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002179 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002180 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002181 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002182 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 5-10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002183 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 50% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002184 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002185 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002186 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002187 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002188 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002189 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002190 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 75% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002191 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 25% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002192 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002193 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002194 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 70% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002195 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002196 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 80% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002197 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 65% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002198 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002199 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002200 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002201 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002202 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002203 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 25% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002204 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002205 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002206 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002207 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002208 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002209 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002210 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002211 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 15% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002212 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML16 Methyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoate C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Non beta lactone inhibitor (AV170 derivative) 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002213 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML21 Methyl 4-(2-(3,4,5-trimethoxyphenyl)acetoxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002214 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML33 Methyl 4-((3-(1H-indol-3-yl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002215 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML03 Isopropyl 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2c[nH]c3ccccc23)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002216 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML23 methyl 3-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoate COc1cc(CCC(=O)Oc2ccc(cc2)C(=O)OC(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002217 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH18 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC(=O)c1cccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c1 Non beta lactone inhibitor (AV170 derivative) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002218 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML14 Butyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3noc(C)n3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002219 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML27 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate CCCCOC(=O)CCc1cc(OC)c(OC)c(OC)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002220 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH19 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002221 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML25 4-formylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3oc(C)nn3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002222 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML05 4-Methoxyphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(C=O)cc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002223 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML06 Phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002224 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML28 4-(Dimethylamino)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 60% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002225 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML92 Methyl 4-((3-(3,4-dimethoxyphenyl)propanoyl)oxy)benzoate COc1cc(CCC(=O)Oc2ccc(cc2)N(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002226 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML57 Methyl 4-((3-(3-acetylphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2ccc(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 55% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002227 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML09 Cyclohexyl 3-(3,4,5-trimethoxyphenyl)propanoate COC(=O)c1ccc(OC(=O)CCc2cccc(c2)C(C)=O)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002228 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML18 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoic acid COc1cc(CCC(=O)OC2CCCCC2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002229 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML20 Methyl 4-(((3,4,5-trimethoxybenzyl)carbamoyl)oxy)benzoate COc1cc(CCC(=O)Oc2ccc(cc2)C(O)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 30% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002230 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML68 methyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoate COC(=O)C1=CC=C(OC(=O)CCC2=CC=CS2)C=C1 Non beta lactone inhibitor (AV170 derivative) 5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002231 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV134 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-sulfonamide CC(C)(C)C(=O)N1CCC(CC1)S(=O)(=O)NC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002232 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML31 Methyl 4-(hept-6-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 15% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002233 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML24 2-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 55% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002234 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML30 Methyl 4-(undec-10-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCCCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002235 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML74 4-(Methoxycarbonyl)phenyl 3,4,5-trimethoxybenzoate COC(=O)c1ccc(OC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 75% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002236 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML12 4-Nitrophenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002237 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV137 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamide CC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002238 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML16 Methyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002239 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML21 Methyl 4-(2-(3,4,5-trimethoxyphenyl)acetoxy)benzoate COC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002240 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML33 Methyl 4-((3-(1H-indol-3-yl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2c[nH]c3ccccc23)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002241 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML03 Isopropyl 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COc1cc(CCC(=O)Oc2ccc(cc2)C(=O)OC(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 90-95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002242 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML23 methyl 3-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoate COC(=O)c1cccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c1 Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002243 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH18 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3noc(C)n3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002244 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML14 Butyl 3-(3,4,5-trimethoxyphenyl)propanoate CCCCOC(=O)CCc1cc(OC)c(OC)c(OC)c1 Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002245 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML27 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 92% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002246 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH19 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3oc(C)nn3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002247 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML25 4-formylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(C=O)cc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 80% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002248 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML05 4-Methoxyphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002249 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML06 Phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002250 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML28 4-(Dimethylamino)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)N(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002251 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML92 Methyl 4-((3-(3,4-dimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2ccc(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002252 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML57 Methyl 4-((3-(3-acetylphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cccc(c2)C(C)=O)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002253 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML09 Cyclohexyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)OC2CCCCC2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002254 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML18 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoic acid COc1cc(CCC(=O)Oc2ccc(cc2)C(O)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002255 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML20 Methyl 4-(((3,4,5-trimethoxybenzyl)carbamoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)NCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002256 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML68 methyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoate COC(=O)c1ccc(OC(=O)CCc2sccc2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002257 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV134 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-sulfonamide CC(C)(C)C(=O)N1CCC(CC1)[S](=O)(=O)Nc2ccc(cc2)N3CCCC3=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002258 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML31 Methyl 4-(hept-6-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002259 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML24 2-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 8% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002260 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML30 Methyl 4-(undec-10-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCCCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002261 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML74 4-(Methoxycarbonyl)phenyl 3,4,5-trimethoxybenzoate COC(=O)c1ccc(OC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002262 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML12 4-Nitrophenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002263 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV137 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamide CC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002264 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML16 Methyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002265 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML21 Methyl 4-(2-(3,4,5-trimethoxyphenyl)acetoxy)benzoate COC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 75% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002266 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML33 Methyl 4-((3-(1H-indol-3-yl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2c[nH]c3ccccc23)cc1 Non beta lactone inhibitor (AV170 derivative) 70% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002267 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML03 Isopropyl 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COc1cc(CCC(=O)Oc2ccc(cc2)C(=O)OC(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 60% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002268 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML23 methyl 3-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoate COC(=O)c1cccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c1 Non beta lactone inhibitor (AV170 derivative) 55% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002269 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH18 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3noc(C)n3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 50% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002270 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML14 Butyl 3-(3,4,5-trimethoxyphenyl)propanoate CCCCOC(=O)CCc1cc(OC)c(OC)c(OC)c1 Non beta lactone inhibitor (AV170 derivative) 50% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002271 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML27 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 45% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002272 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH19 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3oc(C)nn3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 35% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002273 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML25 4-formylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(C=O)cc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 30% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002274 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML05 4-Methoxyphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 15% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002275 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML06 Phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002276 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML28 4-(Dimethylamino)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)N(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002277 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML92 Methyl 4-((3-(3,4-dimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2ccc(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002278 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML57 Methyl 4-((3-(3-acetylphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cccc(c2)C(C)=O)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002279 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML09 Cyclohexyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)OC2CCCCC2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002280 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML18 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoic acid COc1cc(CCC(=O)Oc2ccc(cc2)C(O)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002281 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML20 Methyl 4-(((3,4,5-trimethoxybenzyl)carbamoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)NCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002282 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML68 methyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoate COC(=O)C1=CC=C(OC(=O)CCC2=CC=CS2)C=C1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002283 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV134 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-sulfonamide CC(C)(C)C(=O)N1CCC(CC1)S(=O)(=O)NC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002284 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML31 Methyl 4-(hept-6-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002285 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML24 2-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002286 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML30 Methyl 4-(undec-10-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCCCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002287 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML74 4-(Methoxycarbonyl)phenyl 3,4,5-trimethoxybenzoate COC(=O)c1ccc(OC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002288 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML12 4-Nitrophenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002289 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV137 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamide CC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002290 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML73 Methyl 4-((2-(3,4,5-trimethoxybenzyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(=C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002291 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML91 Methyl (E)-4-((3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002292 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML43 Methyl 4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002293 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML38 Methyl (E)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(/C)=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002294 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML37 Methyl 3-methyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002295 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML15 Methyl 3,5-dimethyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1cc(C)c(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002296 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML89 Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002297 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML90 Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002298 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML95 Methyl (R)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 55% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002299 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML96 Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 10% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002300 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML73 Methyl 4-((2-(3,4,5-trimethoxybenzyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(=C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002301 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML91 Methyl (E)-4-((3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002302 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML43 Methyl 4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002303 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML38 Methyl (E)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(/C)=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 70% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002304 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML37 Methyl 3-methyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002305 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML15 Methyl 3,5-dimethyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1cc(C)c(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002306 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML89 Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002307 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML90 Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 60% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002308 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML95 Methyl (R)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 10% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002309 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML96 Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002310 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML73 Methyl 4-((2-(3,4,5-trimethoxybenzyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(=C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 60% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002311 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML91 Methyl (E)-4-((3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002312 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML43 Methyl 4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 15% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002313 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML38 Methyl (E)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(/C)=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002314 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML37 Methyl 3,5-dimethyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1cc(C)c(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002315 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML15 Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002316 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML89 Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002317 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML90 Methyl (R)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 15% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002318 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML95 Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002319 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML96 Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002320 26083639 Hsp100 NA Human NA NA Antiproliferative activity AV170 methyl 4-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) NA NA NA NA NA NA NA NA NA NA 10 MTT viability assay NA NA NA A549 Cancer HSPMDB002321 26083639 Hsp100 NA Human NA NA Antiproliferative activity ML21 methyl 4-{[2-(3,4,5-trimethoxyphenyl)acetyl]oxy}benzoate COC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) NA NA NA NA NA NA NA NA NA NA 10 MTT viability assay NA NA NA A549 Cancer HSPMDB002322 26083639 Hsp100 NA Human NA NA Antiproliferative activity ML89 Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) NA NA NA NA NA NA NA NA NA NA 10 MTT viability assay NA NA NA A549 Cancer HSPMDB002323 26083639 Hsp100 NA Human NA NA Antiproliferative activity ML90 Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) NA NA NA NA NA NA NA NA NA NA 5-Oct MTT viability assay NA NA NA A549 Cancer HSPMDB002324 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV145 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Isopropyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamide CC(C)n1ncc2cc(cnc12)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 10 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002325 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV280 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3,4-dimethylbenzyl)-1H-pyrazolo[3,4-b]pyridine5-carboxamide (AV280) Cc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1C COMAS Library NA NA NA 1.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002326 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV191 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Benzyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamide O=C(NCc1coc(n1)c2sccc2)c3cnc4n(Cc5ccccc5)ncc4c3 COMAS Library NA NA NA 2 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002327 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV267 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide COc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1 COMAS Library NA NA NA 2.2 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002328 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV261 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(2-Phenethyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide CCc1ccccc1n2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5 COMAS Library NA NA NA 2.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002329 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV253 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide Cc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1 COMAS Library NA NA NA 2.4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002330 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV259 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Phenylpropyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide O=C(NCc1coc(n1)c2sccc2)c3cnc4n(CCCc5ccccc5)ncc4c3 COMAS Library NA NA NA 3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002331 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV268 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide Cc1cccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)c1 COMAS Library NA NA NA 3.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002332 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV264 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Cyanobenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide O=C(NCc1coc(n1)c2sccc2)c3cnc4n(Cc5cccc(c5)C#N)ncc4c3 COMAS Library NA NA NA 4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002333 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV266 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide COc1cccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)c1 COMAS Library NA NA NA 4.4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002334 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV265 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Cyanobenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide O=C(NCc1coc(n1)c2sccc2)c3cnc4n(Cc5ccc(cc5)C#N)ncc4c3 COMAS Library NA NA NA 5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002335 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV279 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Isopropylbenzyl)-1H-pyrazolo[3,4-b]pyridine5-carboxamide CC(C)c1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1 COMAS Library NA NA NA 5.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002336 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV145 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Isopropyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamide CC(C)n1ncc2cc(cnc12)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 10 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002337 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV286 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzylaminocarbonylamino)benzamide O=C(NCc1ccccc1)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 0.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002338 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV241 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(tert-butyloxycarbonylamino)benzamide CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3 COMAS Library NA NA NA 1.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002339 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV285 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzyloxycarbonylamino)benzamide O=C(Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3)OCc4ccccc4 COMAS Library NA NA NA 2.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002340 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV236 4-(4-ethoxybenzenesulfonamido)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamide CCOc1ccc(cc1)[S](=O)(=O)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002341 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV243 4-(cyclopropylsulfamoyl)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamide O=C(NCc1coc(n1)c2sccc2)c3ccc(cc3)[S](=O)(=O)NC4CC4 COMAS Library NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002342 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV224 4-(dimethylsulfamoyl)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamide CN(C)[S](=O)(=O)c1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3 COMAS Library NA NA NA 6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002343 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV245 4-methanesulfonamido-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamide C[S](=O)(=O)Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3 COMAS Library NA NA NA 8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002344 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV235 4-Acetamido-N-((2-(thiophen-2-yl)oxazol-4-yl)methyl)benzamide CC(=O)Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3 COMAS Library NA NA NA 9.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002345 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV145 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Isopropyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamide CC(C)n1ncc2cc(cnc12)C(=O)NCc3coc(n3)c4sccc4 COMAS Library 98% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002346 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV280 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3,4-dimethylbenzyl)-1H-pyrazolo[3,4-b]pyridine5-carboxamide (AV280) Cc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1C COMAS Library 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002347 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV286 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzylaminocarbonylamino)benzamide O=C(NCc1ccccc1)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4 COMAS Library 55% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002348 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV321 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(2-(3-(But-3-ynyl)-3H-diazirin-3- yl)ethyloxycarbonylamino)benzamide O=C(Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3)OCCC4(CCC#C)N=N4 COMAS Library 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002349 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV286 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzylaminocarbonylamino)benzamide O=C(NCc1ccccc1)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 2.1 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002350 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C2 COMAS Library NA NA NA 10.1 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002351 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C3 COMAS Library NA NA NA 21.1 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002352 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C4 COMAS Library NA NA NA 51.2 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002353 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C5 COMAS Library NA NA NA 78.1 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002354 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C6 COMAS Library NA NA NA >95 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002355 25944857 Hsp100 ClpP1P2 Human Cytosol NA Antibacterial activity 100, (Bortezomib) [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 90% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002356 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity 100, (Bortezomib) [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 90% at 3 uM Bacterial growth inhibition assay (OD based) NA NA NA M. bovis Tuberculosis HSPMDB002357 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity 100, (Bortezomib) [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 30% Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002358 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity 100, (Bortezomib) + Amikacin [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 90% Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002359 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity 100, (Bortezomib) + streptomycin [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 95% Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002360 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Bz-al (2S)-N-[(2S)-4-methyl-1-oxopentan-2-yl]-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamide CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)C=O Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 5% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002361 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity CEP-18770 (Delanzomib) [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenylpyridine-2-carbonyl)amino]butanoyl]amino]-3-methylbutyl]boronic acid B(C(CC(C)C)NC(=O)C(C(C)O)NC(=O)C1=CC=CC(=N1)C2=CC=CC=C2)(O)O Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 80% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002362 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity MG-262 [(1R)-3-methyl-1-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)(O)O Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 45% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002363 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity MG-132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 10% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002364 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity MLN-2238 (Ixazomib) [(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 60% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002365 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10001 1-[(3,5-difluorophenyl)methyl]-1-[(2E)-hept-2-enoyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea FC=1C=C(C=C(C1)F)CN(C(=O)N[C@@H]1C(N2CCC[C@H]2C(C2CCCC[C@H]2C(N[C@H](C(N2CCC[C@H]2C(OC1)=O)=O)C)=O)=O)=O)C(\C=C\CCCC)=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 100 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002366 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP2 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 25 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002367 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP3 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 100 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002368 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP4 1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]-1-[(2E)-hept-2-enoyl]urea CCCC\C=C\C(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C1=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 50 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002369 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10011 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C(=O)[C@H](COC(=O)[C@@H]2CCCN2C1=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 50 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002370 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10001 1-[(3,5-difluorophenyl)methyl]-1-[(2E)-hept-2-enoyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea FC=1C=C(C=C(C1)F)CN(C(=O)N[C@@H]1C(N2CCC[C@H]2C(C2CCCC[C@H]2C(N[C@H](C(N2CCC[C@H]2C(OC1)=O)=O)C)=O)=O)=O)C(\C=C\CCCC)=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 1 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002371 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP2 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 1.25 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002372 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP3 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA >100 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002373 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP4 1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]-1-[(2E)-hept-2-enoyl]urea CCCC\C=C\C(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C1=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 0.125 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002374 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10011 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C(=O)[C@H](COC(=O)[C@@H]2CCCN2C1=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 5 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002375 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10001 1-[(3,5-difluorophenyl)methyl]-1-[(2E)-hept-2-enoyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea FC=1C=C(C=C(C1)F)CN(C(=O)N[C@@H]1C(N2CCC[C@H]2C(C2CCCC[C@H]2C(N[C@H](C(N2CCC[C@H]2C(OC1)=O)=O)C)=O)=O)=O)C(\C=C\CCCC)=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >100 ug/ml (MIC99) E. coli Bacterial infection HSPMDB002376 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10011 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C(=O)[C@H](COC(=O)[C@@H]2CCCN2C1=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >100 ug/ml (MIC99) E. coli Bacterial infection HSPMDB002377 19206121 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA R1 trans-4-methyl-3-(8-nonen-1-yl)oxetan-2-one C[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA 3 NA NA NA NA NA Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002378 19206121 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA U1 trans-3-(8-Nonen-1-yl)-4-pheneth-1-yloxetan-2-one CCC1(CC=CC=C1)[C@@H]2OC(=O)[C@H]2CCCCCCCC=C Beta lactone analogue NA NA NA 7 NA NA NA NA NA Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002379 26675528 Hsp100 ClpP Human Cytosol NA Antiproliferative activity Cisplatin dichloroplatinumdiamine N.N.Cl[Pt]Cl Chemical compound NA NA NA NA NA NA NA NA NA NA <50% Bacterial growth inhibition assay (OD based) NA NA NA HeLa Cancer HSPMDB002380 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA DFP Diisopropyl fluorophosphate CC(C)O[P](F)(=O)OC(C)C Chemical compound 95% NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002381 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COc1ccc(cc1)C2C(CCCC#C)OC2=O Chemical compound 98% NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002382 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS09 4-(4-ethynylbenzoyl)-2-(undec-10-enoyl)-1??,2-thiazetidine-1,1-dione C=CCCCCCCCCC(=O)N1CC(C(=O)c2ccc(cc2)C#C)[S]1(=O)=O Chemical compound 99% NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002383 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA DCI 3,4-Dichloroisocoumarine ClC1=C(Cl)c2ccccc2C(=O)O1 Chemical compound 60% at 25ºC for 1 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002384 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA CMK chloromethylketone CC(Cl)=O Chemical compound 85% at 25ºC for 1 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002385 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA FP Diisopropyl fluorophosphate CC(C)O[P](F)(=O)OC(C)C Chemical compound 60% at 25ºC for 1 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002386 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS02 2-(hex-5-ynoyl)-1??,2-thiazetidine-1,1-dione O=C(CCCC#C)N1CC[S]1(=O)=O Chemical compound 75% at 25ºC for 1 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002387 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA DCI 3,4-Dichloroisocoumarine ClC1=C(Cl)c2ccccc2C(=O)O1 Chemical compound 98% at 37ºC for 2 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002388 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA CMK chloromethylketone CC(Cl)=O Chemical compound 98% at 37ºC for 2 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002389 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA FP Diisopropyl fluorophosphate CC(C)O[P](F)(=O)OC(C)C Chemical compound 99% at 37ºC for 2 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002390 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS02 2-(hex-5-ynoyl)-1??,2-thiazetidine-1,1-dione O=C(CCCC#C)N1CCS1(=O)=O Chemical compound 98% at 37ºC for 2 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002391 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS07 2-acetyl-4-(4-ethynylbenzoyl)-1??,2-thiazetidine-1,1-dione CC(=O)N1CC(C(=O)C2=CC=C(C=C2)C#C)S1(=O)=O Chemical compound NA NA NA 0.98 at 1 uM NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002392 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS07 2-acetyl-4-(4-ethynylbenzoyl)-1??,2-thiazetidine-1,1-dione CC(=O)N1CC(C(=O)C2=CC=C(C=C2)C#C)S1(=O)=O Chemical compound NA NA NA 0.98 at 0.4 uM NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002393 18847196 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA Lactone D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Beta lactone analogue NA NA NA 6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002394 18847196 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA Lactone E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Beta lactone analogue NA NA NA 4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002395 18847196 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA Lactone G2 4-(pent-4-yn-1-yl)-3-pentyloxetan-2-one CCCCCC1C(CCCC#C)OC1=O Beta lactone analogue NA NA NA 31 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002396 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.37 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002397 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-694 N,N’-dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Small molecule NA NA NA 2 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002398 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-485A N 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamine Fc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1 Small molecule NA NA NA 0.45 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002399 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-862 3-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazole CC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3 Small molecule NA NA NA 2.66 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002400 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-873 3-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridine Cc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=O Small molecule NA NA NA 0.03 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002401 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.36 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002402 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-694 N,N’-dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Small molecule NA NA NA 9.13 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002403 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-485A N 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamine Fc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1 Small molecule NA NA NA 2.47 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002404 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-862 3-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazole CC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3 Small molecule NA NA NA 2.79 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002405 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-873 3-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridine Cc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=O Small molecule NA NA NA 0.02 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002406 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 20.7 uM at 0 minute NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002407 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 1.13 uM at 7.5 minutes NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002408 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.504 uM at 15 minutes NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002409 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.196 uM at 30 minutes NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002410 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.166 uM at 60 minutes NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002411 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 3.5 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002412 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-694 N,N’-dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Small molecule NA NA NA 3.2 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002413 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-485A N 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamine Fc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1 Small molecule NA NA NA 2.8 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002414 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-862 3-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazole CC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3 Small molecule NA NA NA >10 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002415 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-873 3-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridine Cc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=O Small molecule NA NA NA 0.4 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002416 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 3 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002417 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-694 N,N’-dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Small molecule NA NA NA 3.6 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002418 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-485A N 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamine Fc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1 Small molecule NA NA NA 4.1 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002419 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-862 3-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazole CC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3 Small molecule NA NA NA >10 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002420 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-873 3-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridine Cc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=O Small molecule NA NA NA 0.7 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002421 23892893 Hsp100 p97 Bacteria Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Binding Affinity NA NMS-249 4-(5-cyclopentylsulfanyl-4-pyridin-3-yl-4H-[1,2,4]triazol-3-ylmethoxy)-benzoic acid methyl ester COC(=O)c1ccc(OCc2nnc(SC3CCCC3)n2c4cccnc4)cc1 Small molecule NA 1.03 NA NA NA NA NA NA Nucleotide binding domain (D2) Isothermal titration calorimetry (ITC) NA NA NA NA NA NA NA HSPMDB002422 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 1 N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamide CCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1 Library of small molecule structures NA NA NA 30 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002423 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 2 2,20,200-((1,3,5-Triazin-2,4,6-triyl)tris(sulfanediyl))-tris-(N-(furan-2-ylmethyl)acetamide) O=C(CNC(=O)OCc1ccccc1)N[C@@H](CCC(=O)OCc2ccccc2)C(=O)OCc3ccccc3 Library of small molecule structures NA NA NA 92 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002424 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 3 Dibenzyl ((benzyloxy)carbonyl)glycylglutamate C(C1=CC=CC=C1)OC(=O)NCC(=O)N[C@@H](CCC(=O)OCC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002425 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 4 N,N-(5-(Thiazol-2-ylcarbamoyl)-1,3-phenylene)bis(2-phenoxyacetamide) COc1ccc(CNC(=O)C(=O)N/N=C/c2oc(CN[S](=O)(=O)c3ccc(Br)cc3)cc2)cc1 Library of small molecule structures NA NA NA 88 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002426 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 5 (E)-2-(2-((5-(((4-Bromophenyl)sulfonamido)methyl)furan-2-yl)methylene)hydrazinyl)-N-(4-methoxybenzyl)-2-oxoacetamide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)c3ccccc3)n1 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002427 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 6 2-((6-Methyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4-yl)thio)-N-(2-phenylacetyl)acetohydrazide CCCCOc1ccc(c(C)c1)c2nn(cc2\C=C(C#N)\C(=O)NCc3occc3)c4ccccc4 Library of small molecule structures NA NA NA 26 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002428 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 7 (E)-3-(3-(4-Butoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-cyano-N-(furan-2-ylmethyl)acrylamide CCCOc1ccc(cc1F)c2nn(cc2\C=C\3SC(=S)N(CCc4ccccc4)C3=O)c5ccccc5 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002429 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 8 (Z)-5-((3-(3-Fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-phenethyl-2-thioxothiazolidin-4-one CCc1ccc(CSc2ncc(Cl)c(n2)C(=O)NCCC(=O)Nc3ccc(Cl)cc3)cc1 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002430 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 9 5-Chloro-N-(3-((4-chlorophenyl)amino)-3-oxopropyl)-2-((4-ethylbenzyl)thio)pyrimidine-4-carboxamide ClC=1C(=NC(=NC1)SCC1=CC=C(C=C1)CC)C(=O)NCCC(=O)NC1=CC=C(C=C1)Cl Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002431 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 10 N-(3-methoxyphenyl)-2-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}acetamide COC1=CC=CC(NC(=O)CSC2=NC3=C(C4=C(COC(C4)C(C)C)S3)C(=O)N2CCC2=CC=CC=C2)=C1 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002432 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 11 2-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}-N-(4-phenylbutan-2-yl)acetamide CC(CCC1=CC=CC=C1)NC(=O)CSC1=NC2=C(C3=C(COC(C3)C(C)C)S2)C(=O)N1CCC1=CC=CC=C1 Library of small molecule structures NA NA NA 23 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002433 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 12 N-Benzyl-2-((6-isopropyl-4-oxo-3-phenethyl-3,5,6,8-tetrahydro-4H-pyrano[40,30:4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide CCCC1=CC(=O)Oc2cc(OCC(=O)N[C@@H](CSCc3ccccc3)C(O)=O)ccc12 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002434 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 13 S-Benzyl-N-(2-((2-oxo-4-propyl-2H-chromen-7-yl)oxy)acetyl)-cysteine COc1ccc(cc1)C(=O)CSc2nc(C)cc(SCC(=O)N(N)C(=O)Cc3ccccc3)n2 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002435 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 22 2-(2-(2-(4-Methoxyphenyl)-2-oxoethylthio)-6-methylpyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazide COC1=CC=C(C=C1)C(CSC1=NC(=CC(=N1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O)C)=O Library of small molecule structures NA NA NA 34.7 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002436 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 23 2-(2-(2-(4-(Diethylamino)phenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)N3CCOCC3)n1 Library of small molecule structures NA NA NA 28.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002437 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 24 2-(6-Methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCCN3CCOCC3)n1 Library of small molecule structures NA NA NA 28.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002438 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 25 2-(6-Methyl-2-(2-morpholinoethylthio)pyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)c3ccc(cc3)C#N)n1 Library of small molecule structures NA NA NA 30.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002439 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 26 2-(2-(2-(4-Cyanophenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccccc4 Library of small molecule structures NA NA NA 37.4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002440 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 30 1-Benzyl-6-oxo-2-(2-oxo-2-phenylethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide COc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 24 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002441 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 31 1-Benzyl-2-(2-(4-methoxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6 dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)NNC(=O)Cc4ccccc4 Library of small molecule structures NA NA NA 45 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002442 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 32 1-Benzyl-6-oxo-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(NCCCc1ccccc1)C2=CN=C(SCCN3CCOCC3)N(Cc4ccccc4)C2=O Library of small molecule structures NA NA NA 72.6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002443 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 33 1-Benzyl-2-(2-morpholinoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide CCOC(=O)CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3 Library of small molecule structures NA NA NA 10.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002444 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 34 Ethyl-2-(1-benzyl-6-oxo-5-(3-phenylpropylcarbamoyl)-1,6-dihydropyrimidin-2-ylthio)acetate CCN(CC)c1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 58.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002445 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 35 1-Benzyl-2-(2-(4-(diethylamino)phenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide Oc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002446 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 36 1-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#N Library of small molecule structures NA NA NA 53 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002447 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 37 1-Benzyl-2-(2-(4-cyanophenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)N4CCOCC4 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002448 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 38 1-Benzyl-2-(2-morpholino-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide C(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)N1CCOCC1 Library of small molecule structures NA NA NA 46 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002449 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 40 Ethyl-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-pyrimidin-4-one-5-carboxylate CCOC(=O)C1=CN=C(NC1=O)SCCN2CCOCC2 Library of small molecule structures NA NA NA 42 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002450 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 41 Ethyl 2-(2-morpholinoethylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxylate O1CCN(CC1)CCSC=1NC(C(=CN1)C(=O)OCC)=O Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002451 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 42 Ethyl 2-(2-morpholinoethylthio)-1-(2-oxo-2-phenylethyl)-pyrimidin-4-one-5-carboxylate OC(=O)C1=CN=C2SC(=C(CN2C1=O)c3ccccc3)CN4CCOCC4 Library of small molecule structures NA NA NA 40 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002452 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 43 2-(Morpholinomethyl)-6-oxo-3-phenyl-4,6-dihydropyrimido[2,1-b][1,3]thiazine-7-carboxylic acid O1CCN(CC1)CC1=C(CN2C(S1)=NC=C(C2=O)C(=O)O)C2=CC=CC=C2 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002453 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 44 2-(2-Morpholinoethylthio)-N-(3-phenylpropyl)-pyrimidin-4-one-5-carboxamide CCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1 Library of small molecule structures NA NA NA 44 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002454 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 1 N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamide C(C)C1=NN=C(S1)NC(CSC1=NN=C(N1CCOC)C1=CC2=CC=CC=C2C=C1O)=O Library of small molecule structures NA NA 12.1 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002455 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 2 2,2,2-((1,3,5-Triazin-2,4,6-triyl)tris(sulfanediyl))-tris-(N-(furan-2-ylmethyl)acetamide) O=C(CNC(=O)OCc1ccccc1)N[C@@H](CCC(=O)OCc2ccccc2)C(=O)OCc3ccccc3 Library of small molecule structures NA NA 38 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002456 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 4 N,N-(5-(Thiazol-2-ylcarbamoyl)-1,3-phenylene)bis(2-phenoxyacetamide) COc1ccc(CNC(=O)C(=O)N/N=C/c2oc(CN[S](=O)(=O)c3ccc(Br)cc3)cc2)cc1 Library of small molecule structures NA NA 36 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002457 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 6 2-((6-Methyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4-yl)thio)-N0-(2-phenylacetyl)acetohydrazide CCCCOc1ccc(c(C)c1)c2nn(cc2\C=C(C#N)\C(=O)NCc3occc3)c4ccccc4 Library of small molecule structures NA NA 11 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002458 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 11 2-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}-N-(4-phenylbutan-2-yl)acetamide CC(CCC1=CC=CC=C1)NC(=O)CSC1=NC2=C(C3=C(COC(C3)C(C)C)S2)C(=O)N1CCC1=CC=CC=C1 Library of small molecule structures NA NA 9 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002459 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 22 2-(2-(2-(4-Methoxyphenyl)-2-oxoethylthio)-6-methylpyrimidin-4-ylthio)-N0-(2-phenylacetyl)acetohydrazide CCN(CC)c1ccc(cc1)C(=O)CSc2nc(C)cc(SCC(=O)N(N)C(=O)Cc3ccccc3)n2 Library of small molecule structures NA NA 14.2 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002460 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 23 2-(2-(2-(4-(Diethylamino)phenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N0-(2-^phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)N3CCOCC3)n1 Library of small molecule structures NA NA 11.6 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002461 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 24 2-(6-Methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4-ylthio)-N0-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCCN3CCOCC3)n1 Library of small molecule structures NA NA 11.8 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002462 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 25 2-(6-Methyl-2-(2-morpholinoethylthio)pyrimidin-4-yl-thio)-N0-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)c3ccc(cc3)C#N)n1 Library of small molecule structures NA NA 12.3 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002463 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 26 2-(2-(2-(4-Cyanophenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N0-(2-phenylacetyl)acetohydrazide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccccc4 Library of small molecule structures NA NA 15.3 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002464 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 30 1-Benzyl-6-oxo-2-(2-oxo-2-phenylethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide COc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA 10 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002465 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 31 1-Benzyl-2-(2-(4-methoxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6 dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)NNC(=O)Cc4ccccc4 Library of small molecule structures NA NA 18 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002466 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 32 1-Benzyl-6-oxo-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(NCCCc1ccccc1)C2=CN=C(SCCN3CCOCC3)N(Cc4ccccc4)C2=O Library of small molecule structures NA NA 29.5 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002467 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 33 1-Benzyl-2-(2-morpholinoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide CCOC(=O)CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3 Library of small molecule structures NA NA 2.3 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002468 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 34 Ethyl-2-(1-benzyl-6-oxo-5-(3-phenylpropylcarbamoyl)-1,6-dihydropyrimidin-2-ylthio)acetate CCN(CC)c1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA 23.8 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002469 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 36 1-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#N Library of small molecule structures NA NA 21.6 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002470 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 38 1-Benzyl-2-(2-morpholino-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide C(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)N1CCOCC1 Library of small molecule structures NA NA 18.8 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002471 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 40 Ethyl-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-pyrimidin-4-one-5-carboxylate CCOC(=O)C1=CN=C(NC1=O)SCCN2CCOCC2 Library of small molecule structures NA NA 17 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002472 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 42 Ethyl 2-(2-morpholinoethylthio)-1-(2-oxo-2-phenylethyl)-pyrimidin-4-one-5-carboxylate OC(=O)C1=CN=C2SC(=C(CN2C1=O)c3ccccc3)CN4CCOCC4 Library of small molecule structures NA NA 16 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002473 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 44 2-(2-Morpholinoethylthio)-N-(3-phenylpropyl)-pyrimidin-4-one-5-carboxamide CCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1 Library of small molecule structures NA NA 18 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002474 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 1 N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamide C(C)C1=NN=C(S1)NC(CSC1=NN=C(N1CCOC)C1=CC2=CC=CC=C2C=C1O)=O Library of small molecule structures NA NA NA 27 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002475 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 6 2-((6-Methyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4-yl)thio)-N0-(2-phenylacetyl)acetohydrazide CCCCOc1ccc(c(C)c1)c2nn(cc2\C=C(C#N)\C(=O)NCc3occc3)c4ccccc4 Library of small molecule structures NA NA NA 75 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002476 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 11 2-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}-N-(4-phenylbutan-2-yl)acetamide CC(CCC1=CC=CC=C1)NC(=O)CSC1=NC2=C(C3=C(COC(C3)C(C)C)S2)C(=O)N1CCC1=CC=CC=C1 Library of small molecule structures NA NA NA 25 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002477 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 22 2-(2-(2-(4-Methoxyphenyl)-2-oxoethylthio)-6-methylpyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazide COC1=CC=C(C=C1)C(CSC1=NC(=CC(=N1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O)C)=O Library of small molecule structures NA NA NA 11.8 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002478 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 23 2-(2-(2-(4-(Diethylamino)phenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide C(C)N(C1=CC=C(C=C1)C(CSC1=NC(=CC(=N1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O)C)=O)CC Library of small molecule structures NA NA NA 12.14 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002479 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 24 2-(6-Methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazide CC1=CC(=NC(=N1)SCC(=O)N1CCOCC1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O Library of small molecule structures NA NA NA 17.3 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002480 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 25 2-(6-Methyl-2-(2-morpholinoethylthio)pyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide CC1=CC(=NC(=N1)SCCN1CCOCC1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O Library of small molecule structures NA NA NA 14.4 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002481 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 26 2-(2-(2-(4-Cyanophenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccccc4 Library of small molecule structures NA NA NA 12.4 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002482 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 30 1-Benzyl-6-oxo-2-(2-oxo-2-phenylethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide COc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 20 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002483 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 31 1-Benzyl-2-(2-(4-methoxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6 dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)NNC(=O)Cc4ccccc4 Library of small molecule structures NA NA NA 2.4 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002484 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 33 1-Benzyl-2-(2-morpholinoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide CCOC(=O)CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3 Library of small molecule structures NA NA NA 9 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002485 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 34 Ethyl-2-(1-benzyl-6-oxo-5-(3-phenylpropylcarbamoyl)-1,6-dihydropyrimidin-2-ylthio)acetate CCN(CC)c1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 15.9 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002486 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 35 1-Benzyl-2-(2-(4-(diethylamino)phenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide Oc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 9.2 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002487 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 36 1-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#N Library of small molecule structures NA NA NA 9.2 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002488 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 37 1-Benzyl-2-(2-(4-cyanophenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide C(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)C1=CC=C(C=C1)C#N Library of small molecule structures NA NA NA 13.7 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002489 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 38 1-Benzyl-2-(2-morpholino-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide C(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)N1CCOCC1 Library of small molecule structures NA NA NA 11.7 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002490 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 40 Ethyl-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-pyrimidin-4-one-5-carboxylate C(C)OC(=O)C=1C(NC(=NC1)SCC(NNC(CC1=CC=CC=C1)=O)=O)=O Library of small molecule structures NA NA NA 82.5 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002491 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 42 Ethyl 2-(2-morpholinoethylthio)-1-(2-oxo-2-phenylethyl)-pyrimidin-4-one-5-carboxylate O1CCN(CC1)CCSC=1N(C=C(C(N1)=O)C(=O)OCC)CC(C1=CC=CC=C1)=O Library of small molecule structures NA NA NA 19 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002492 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 43 2-(Morpholinomethyl)-6-oxo-3-phenyl-4,6-dihydropyrimido[2,1-b][1,3]thiazine-7-carboxylic acid O1CCN(CC1)CC1=C(CN2C(S1)=NC=C(C2=O)C(=O)O)C2=CC=CC=C2 Library of small molecule structures NA NA NA 11 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002493 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 44 2-(2-Morpholinoethylthio)-N-(3-phenylpropyl)-pyrimidin-4-one-5-carboxamide O1CCN(CC1)CCSC1=NC=C(C(N1)=O)C(=O)NCCCC1=CC=CC=C1 Library of small molecule structures NA NA NA 22 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002494 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3S,4S)-4-{2-[3-(dimethylamino)propanesulfonyl]ethyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002495 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3S,4S)-4-{3-[3-(dimethylamino)propanesulfonyl]propyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002496 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 3 (3S,4S)-4-{4-[3-(dimethylamino)propanesulfonyl]butyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002497 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 4 (3S,4S)-4-{5-[3-(dimethylamino)propanesulfonyl]pentyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002498 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 5 trimethyl(3-{3-[(2S,3S)-4-oxo-3-undecyloxetan-2-yl]propanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002499 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 trimethyl(3-{4-[(2S,3S)-4-oxo-3-undecyloxetan-2-yl]butanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@H]1[C@H](CCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 64% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002500 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 7 trimethyl(3-{5-[(2S,3S)-4-oxo-3-undecyloxetan-2-yl]pentanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@H]1[C@H](CCCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002501 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 8 (3S,4S)-4-(2-{[3-(dimethylamino)propyl]sulfanyl}ethyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCSCCCN(C)C)OC1=O Beta lactone analogue 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002502 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 9 (3S,4S)-4-(3-{[3-(dimethylamino)propyl]sulfanyl}propyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCSCCCN(C)C)OC1=O Beta lactone analogue 60% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002503 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 10 (3S,4S)-4-(4-{[3-(dimethylamino)propyl]sulfanyl}butyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCCSCCCN(C)C)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002504 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 11 (3S,4S)-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCCCSCCCN(C)C)OC1=O Beta lactone analogue 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002505 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 12 (3R,4R)-4-{2-[3-(dimethylamino)propanesulfonyl]ethyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 63% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002506 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 13 (3R,4R)-4-{3-[3-(dimethylamino)propanesulfonyl]propyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 92% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002507 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 14 (3R,4R)-4-{4-[3-(dimethylamino)propanesulfonyl]butyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 87% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002508 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 15 (3R,4R)-4-{5-[3-(dimethylamino)propanesulfonyl]pentyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002509 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 16 trimethyl(3-{3-[(2R,3R)-4-oxo-3-undecyloxetan-2-yl]propanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@@H]1[C@@H](CCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 93% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002510 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 17 trimethyl(3-{4-[(2R,3R)-4-oxo-3-undecyloxetan-2-yl]butanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@@H]1[C@@H](CCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 91% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002511 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 18 trimethyl(3-{5-[(2R,3R)-4-oxo-3-undecyloxetan-2-yl]pentanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@@H]1[C@@H](CCCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 91% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002512 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 19 (3R,4R)-4-(2-{[3-(dimethylamino)propyl]sulfanyl}ethyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCSCCCN(C)C)OC1=O Beta lactone analogue 89% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002513 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 20 (3R,4R)-4-(3-{[3-(dimethylamino)propyl]sulfanyl}propyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCSCCCN(C)C)OC1=O Beta lactone analogue 74% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002514 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 21 (3R,4R)-4-(4-{[3-(dimethylamino)propyl]sulfanyl}butyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCCSCCCN(C)C)OC1=O Beta lactone analogue 94% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002515 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 22 (3R,4R)-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCCCSCCCN(C)C)OC1=O Beta lactone analogue 85% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002516 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 23 but-3-yn-1-yl N-(2-phenylethyl)carbamate O=C(NCCC1=CC=CC=C1)OCCC#C Beta lactone analogue 8% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002517 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 4-(but-3-yn-1-yl)-3-(non-8-en-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCC#C)OC1=O Beta lactone analogue 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002518 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 25 but-3-yn-1-yl N-pentylcarbamate CCCCCNC(=O)OCCC#C Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002519 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 26 [(but-3-yn-1-yloxy)(hydroxy)methyl](non-8-en-1-yl)amine OC(NCCCCCCCC=C)OCCC#C Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002520 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 27 methyl undec-10-enoate COC(=O)CCCCCCCCC=C Beta lactone analogue 4% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002521 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 28 tert-butyl undec-10-enoate CC(C)(C)OC(=O)CCCCCCCCC=C Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002522 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 (4S)-4-(but-3-yn-1-yl)-3-dodecyloxetan-2-one CCCCCCCCCCCCC1[C@H](CCC#C)OC1=O Beta lactone analogue 5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002523 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 (3R)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@H]1CCC1=CC=CC=C1 Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002524 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 31 (3S)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@@H]1CCC1=CC=CC=C1 Beta lactone analogue 94% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002525 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 3-(oct-7-en-1-yl)-4-(2-phenylethyl)oxetan-2-one C=CCCCCCCC1C(CCC2=CC=CC=C2)OC1=O Beta lactone analogue 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002526 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 33 3-(oct-7-en-1-yl)-4-[2-(pyridin-3-yl)ethyl]oxetan-2-one C=CCCCCCCC1C(CCC2=CN=CC=C2)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002527 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 34 4-[2-(pyridin-3-yl)ethyl]-3-undecyloxetan-2-one CCCCCCCCCCCC1C(CCC2=CN=CC=C2)OC1=O Beta lactone analogue 5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002528 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 35 4-(dimethylamino)-N-{5-[3-(oct-7-en-1-yl)-4-oxooxetan-2-yl]pentyl}benzamide CN(C)C1=CC=C(C=C1)C(=O)NCCCCCC1OC(=O)C1CCCCCCC=C Beta lactone analogue 70% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002529 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 36 tert-butyl N-{11-[3-(oct-7-en-1-yl)-4-oxooxetan-2-yl]undecyl}carbamate CC(C)(C)OC(=O)NCCCCCCCCCCCC1OC(=O)C1CCCCCCC=C Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002530 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 37 tert-butyl N-{8-[2-(non-8-en-1-yl)-4-oxooxetan-3-yl]octyl}carbamate CC(C)(C)OC(=O)NCCCCCCCCC1C(CCCCCCCC=C)OC1=O Beta lactone analogue 5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002531 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3S,4S)-3-decyl-4-{2-[3-(dimethylamino)propanesulfonyl]ethyl}oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone (library of enantiopure) 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002532 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3S,4S)-3-decyl-4-{3-[3-(dimethylamino)propanesulfonyl]propyl}oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone (library of enantiopure) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002533 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 3 (3S,4S)-3-decyl-4-{4-[3-(dimethylamino)propanesulfonyl]butyl}oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone (library of enantiopure) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002534 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 5 (3-{3-[(2S,3S)-3-decyl-4-oxooxetan-2-yl]propanesulfonyl}propyl)trimethylazanium iodide [I-].CCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone (library of enantiopure) 93% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002535 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 7 (3-{5-[(2S,3S)-3-decyl-4-oxooxetan-2-yl]pentanesulfonyl}propyl)trimethylazanium iodide [I-].CCCCCCCCCC[C@H]1[C@H](CCCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone (library of enantiopure) 93% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002536 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 8 (3S,4S)-3-decyl-4-(2-{[3-(dimethylamino)propyl]sulfanyl}ethyl)oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure) 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002537 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 10 (3S,4S)-3-decyl-4-(4-{[3-(dimethylamino)propyl]sulfanyl}butyl)oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCCCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure) 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002538 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 11 (3S,4S)-3-decyl-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCCCCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure) 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002539 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 22 (3R,4R)-3-decyl-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)oxetan-2-one CCCCCCCCCC[C@@H]1[C@@H](CCCCCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure) 50% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002540 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 3-decyloxetan-2-one CCCCCCCCCCC1COC1=O Beta lactone (library of enantiopure) 10% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002541 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 3-decyloxetan-2-one CCCCCCCCCCC1COC1=O Beta lactone (library of enantiopure) 50% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002542 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 3-decyloxetan-2-one CCCCCCCCCCC1COC1=O Beta lactone (library of enantiopure) 45% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002543 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 31 4-decyloxetan-2-one CCCCCCCCCCC1CC(=O)O1 Beta lactone (library of enantiopure) 1% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002544 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 31 4-decyloxetan-2-one CCCCCCCCCCC1CC(=O)O2 Beta lactone (library of enantiopure) 1% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002545 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 31 4-decyloxetan-2-one CCCCCCCCCCC1CC(=O)O3 Beta lactone (library of enantiopure) 5% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002546 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 3-(2-phenylethyl)oxetan-2-one O=C1OCC1CCC1=CC=CC=C1 Beta lactone (library of enantiopure) 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002547 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 3-(2-phenylethyl)oxetan-2-one O=C1OCC1CCC1=CC=CC=C2 Beta lactone (library of enantiopure) 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002548 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 3-(2-phenylethyl)oxetan-2-one O=C1OCC1CCC1=CC=CC=C3 Beta lactone (library of enantiopure) 95% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002549 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 33 4-(2-phenylethyl)oxetan-2-one O=C1CC(CCC2=CC=CC=C2)O1 Beta lactone (library of enantiopure) 1% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002550 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 33 4-(2-phenylethyl)oxetan-2-one O=C1CC(CCC2=CC=CC=C2)O2 Beta lactone (library of enantiopure) 2% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002551 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 33 4-(2-phenylethyl)oxetan-2-one O=C1CC(CCC2=CC=CC=C2)O3 Beta lactone (library of enantiopure) 1% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002552 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 34 (3R)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@H]1CCC1=CC=CC=C1 Beta lactone (library of enantiopure) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002553 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 34 (3R)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@H]1CCC1=CC=CC=C2 Beta lactone (library of enantiopure) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002554 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 34 (3R)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@H]1CCC1=CC=CC=C3 Beta lactone (library of enantiopure) 40% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002555 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 35 (3S)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@@H]1CCC1=CC=CC=C1 Beta lactone (library of enantiopure) 55% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002556 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 35 (3S)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@@H]1CCC1=CC=CC=C2 Beta lactone (library of enantiopure) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002557 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 35 (3S)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@@H]1CCC1=CC=CC=C3 Beta lactone (library of enantiopure) 98% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002558 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one [H]C(=C)CCCCCCCC1C(CCCC#C)OC1=O Beta lactone (library of enantiopure) 5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002559 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 (3S,4S)-4-(pent-4-yn-1-yl)-3-tridecyloxetan-2-one CCCCCCCCCCCCC[C@H]1[C@H](CCCC#C)OC1=O Beta lactone (library of enantiopure) 13% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002560 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one [H]C(=C)CCCCCCCC1C(CCCC#C)OC1=O Beta lactone (library of enantiopure) 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA E. coli Bacterial infection HSPMDB002561 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 (3S,4S)-4-(pent-4-yn-1-yl)-3-tridecyloxetan-2-one CCCCCCCCCCCCC[C@H]1[C@H](CCCC#C)OC1=O Beta lactone (library of enantiopure) 15% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA E. coli Bacterial infection HSPMDB002562 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one [H]C(=C)CCCCCCCC1C(CCCC#C)OC1=O Beta lactone (library of enantiopure) 70% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002563 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 (3S,4S)-4-(pent-4-yn-1-yl)-3-tridecyloxetan-2-one CCCCCCCCCCCCC[C@H]1[C@H](CCCC#C)OC1=O Beta lactone (library of enantiopure) 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002564 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3R,4R)-3-(8-Nonenyl)-4-(2-phenylethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC1=CC=CC=C1)=O Beta lactone analogue 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002565 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3R,4R)-3-(8-Nonenyl)-4-(2-(3-pyridyl)ethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC=1C=NC=CC1)=O Beta lactone analogue 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002566 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 4 (3R,4R)-4-(4-(N,N-Dimethylamino)benzamido-5-pentyl)-3-(non-8-enyl)oxetan-2-one CN(C)C1=CC=C(C(=O)NC(CCCC)[C@H]2[C@H](C(O2)=O)CCCCCCCC=C)C=C1 Beta lactone analogue 55% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002567 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3R,4R)-3-(8-Nonenyl)-4-(2-phenylethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC1=CC=CC=C1)=O Beta lactone analogue 30% at 20 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002568 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3R,4R)-3-(8-Nonenyl)-4-(2-(3-pyridyl)ethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC=1C=NC=CC1)=O Beta lactone analogue 92% at 20 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002569 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 4 (3R,4R)-4-(4-(N,N-Dimethylamino)benzamido-5-pentyl)-3-(non-8-enyl)oxetan-2-one CN(C)C1=CC=C(C(=O)NC(CCCC)[C@H]2[C@H](C(O2)=O)CCCCCCCC=C)C=C1 Beta lactone analogue 65% at 20 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002570 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3R,4R)-3-(8-Nonenyl)-4-(2-phenylethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC1=CC=CC=C1)=O Beta lactone analogue 25% at 40 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002571 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3R,4R)-3-(8-Nonenyl)-4-(2-(3-pyridyl)ethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC=1C=NC=CC1)=O Beta lactone analogue 90% at 40 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002572 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 4 (3R,4R)-4-(4-(N,N-Dimethylamino)benzamido-5-pentyl)-3-(non-8-enyl)oxetan-2-one CN(C)C1=CC=C(C(=O)NC(CCCC)[C@H]2[C@H](C(O2)=O)CCCCCCCC=C)C=C1 Beta lactone analogue 50% at 40 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002573 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 (3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-one C(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=O Beta lactone analogue 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002574 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 (3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-one C(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=O Beta lactone analogue 15% at 400 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002575 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 (3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-one C(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=O Beta lactone analogue 20% at 600 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002576 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 (3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-one C(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=O Beta lactone analogue 10% at 800 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002577 30543804 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of protease activity NA DCC Dicyclohexylcarbodiimide C1CCC(CC1)N=C=NC2CCCCC2 GSK Library collection NA NA NA 80 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB002578 30543804 Hsp100 ClpC1 Bacteria Cytosol Inhibition of protease activity NA ecumicin (2S,3R)-2-[[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-N-[(3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,31R)-27-[(1R)-1-hydroxyethyl]-6-[(R)-hydroxy(phenyl)methyl]-12-[(4-methoxy-1H-indol-3-yl)methyl]-13,16,22,28,31-pentamethyl-21-(2-methylpropyl)-2,5,8,11,14,17,20,23,26,29-decaoxo-3,9,15,18,24-penta(propan-2-yl)-1-oxa-4,7,10,13,16,19,22,25,28-nonazacyclohentriacont-30-yl]-3-methylpentanamide CCC(C)C(C(=O)NC1C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N(C(=O)C(N(C(=O)C(NC(=O)C(N(C(=O)C(NC(=O)C(N(C1=O)C)C(C)O)C(C)C)C)CC(C)C)C(C)C)C)C(C)C)C)CC2=CNC3=C2C(=CC=C3)OC)C(C)C)C(C4=CC=CC=C4)O)C(C)C)C)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C GSK Library collection NA NA NA 4 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB002579 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-02 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.08 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002580 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-10 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.07 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002581 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-18 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.06 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002582 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-06 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC(F)=CC(F)=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.04 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002583 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-15 NA O=C([C@H](C)NC([C@@](CCC1)([H])N1C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.04 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002584 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-20 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC=C3)NC(/C=C/CCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.03 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002585 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-32 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CN4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.03 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002586 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-04 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.02 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002587 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-13 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.02 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002588 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-17 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CCCCC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.02 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002589 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-21 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3CCCCC3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.00 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002590 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-14 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C=C/CCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.99 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002591 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-30 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.98 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002592 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-05 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.98 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002593 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-25 NA O=C([C@H](CC)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.97 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002594 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-08 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.97 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002595 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-41 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.96 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002596 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-01 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.96 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002597 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-28 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.95 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002598 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-38 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.95 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002599 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-37 NA O=C([C@H](C)NC([C@@]1([H])N(CCC2=C1C=CC=C2)C([C@@]3([H])N(C([C@@H](NC([C@H](CC4=CC(F)=CC(F)=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC3)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002600 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-29 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002601 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-43 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(C=CC=C4)=C4C=C3)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.87 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002602 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-42 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CSC4=C3C=CC=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.87 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002603 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-26 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.86 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002604 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-39 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C4=CC=CC(C(F)(F)F)=C4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.78 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002605 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-11 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.77 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002606 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-09 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.76 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002607 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-03 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.66 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002608 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-27 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C#CCCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.64 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002609 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-07 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCCC(O)=O)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.61 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002610 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-44 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C4=CC=CC=C4C(F)(F)F)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.42 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002611 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-12 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C#CCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.36 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002612 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-19 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C\CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.34 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002613 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-45 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC(C(F)=C3F)=C(F)C(F)=C3F)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.29 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002614 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-23 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C#CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.12 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002615 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-33 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C\CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.07 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002616 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-16 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OCC3=CC=CC=C3)=O)=O)CO4)=O)CCC1)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.06 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002617 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-46 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/COC3([H])OCCCC3)=O)=O)CO4)=O)CCC1)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.02 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002618 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-36 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/CO)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002619 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-24 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(C4=CC=C([N+]([O-])=O)C=C4)=O)=O)CO5)=O)CCC2)=O)=O)N6CCC[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 1 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002620 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-34 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OC(C)(C)C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 2 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002621 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-35 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OC(C)(C)C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 3 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002622 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-31 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)N)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 4 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002623 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-22 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OCC3=CC=CC=C3)=O)=O)CO4)=O)CCC1)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 5 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002624 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-40 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)N)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 6 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002625 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-32 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CN4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.9 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002626 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-06 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC(F)=CC(F)=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.94 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002627 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-30 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.93 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002628 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-41 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.93 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002629 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-28 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.93 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002630 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-25 NA O=C([C@H](CC)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002631 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-14 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C=C/CCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002632 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-15 NA O=C([C@H](C)NC([C@@](CCC1)([H])N1C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002633 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-13 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.91 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002634 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-17 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CCCCC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.91 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002635 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-20 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC=C3)NC(/C=C/CCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.90 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002636 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-38 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.89 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002637 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-02 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.88 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002638 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-29 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.87 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002639 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-37 NA O=C([C@H](C)NC([C@@]1([H])N(CCC2=C1C=CC=C2)C([C@@]3([H])N(C([C@@H](NC([C@H](CC4=CC(F)=CC(F)=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC3)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.86 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002640 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-10 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.85 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002641 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-04 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.78 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002642 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-18 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.72 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002643 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-21 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3CCCCC3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.70 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002644 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-01 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.70 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002645 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-05 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.69 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002646 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-43 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(C=CC=C4)=C4C=C3)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.55 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002647 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-08 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.52 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002648 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-42 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CSC4=C3C=CC=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.49 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002649 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-17 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CC5CCCCC5)=O)CC6=CC(F)=CC(F)=C6)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.81 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002650 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-28 NA O=C(N1CCC[C@]12[H])[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CC[C@@H](C3)C)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.82 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002651 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-14 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/C=C/CCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.79 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002652 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-41 NA O=C(N1CCC[C@]12[H])[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.79 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002653 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-32 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](CNC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.79 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002654 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-29 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.76 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002655 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-38 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CC[C@@H](C3)C)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.76 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002656 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-30 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CC[C@@H](C3)C)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.69 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002657 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-37 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCC6=C3C=CC=C6)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.68 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002658 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-06 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@@H](N(C([C@]3(N(CCC3)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC4=CC(F)=CC(F)=C4)=O)=O)[H])=O)C)C)=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.64 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002659 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-25 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)CC Acyldepsipeptide analogue NA NA NA NA NA NA 0.61 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002660 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-13 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CC5CC5)=O)CC6=CC(F)=CC(F)=C6)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.59 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002661 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-15 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3([H])CCCN3C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.58 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002662 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-20 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCC)=O)CC5=CC(F)=CC=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.53 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002663 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-02 NA O=C(N1CCC[C@]12[H])[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC5=CC=CC=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.52 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002664 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-10 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC5=CC=CC=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.44 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002665 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-04 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@@H](N(C([C@]3(N(CCC3)C([C@H](COC2=O)NC([C@H](NC(/C=C/C=C/CCC)=O)CC4=CC=CC=C4)=O)=O)[H])=O)C)C)=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.32 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002666 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-01 NA O=C(N1CCC[C@]12[H])[C@@H](NC([C@@H](N(C([C@]3(N(CCC3)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC4=CC=CC=C4)=O)=O)[H])=O)C)C)=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.22 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA


Accession_No PMID Target HSP_Name Organism Localization Enzymatic_activity Cellular_activity compound_Name IUPAC_Name SMILES Class Enzymatic_Inhibition Kd Ki IC50 EC50 DC50 RD_Index GI50 Site_of_Interaction Type_of_Enzymatic_Assay Percentage_Cell_ Cellular_assay HSP_client_protein_assay CC50 MIC_MBC Celllines Disease HSPMDB001484 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Hexachlorophene 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol Oc1c(Cl)cc(Cl)c(Cl)c1Cc2c(O)c(Cl)cc(Cl)c2Cl NIH, Spectrum, and Hit finder collection 80.21% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001485 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Tannic acid [2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5 trihydroxybenzoate Oc1cc(cc(O)c1O)C(=O)Oc2cc(cc(O)c2O)C(=O)OC[C@H]3O[C@@H](OC(=O)c4cc(O)c(O)c(OC(=O)c5cc(O)c(O)c(O)c5)c4)[C@H](OC(=O)c6cc(O)c(O)c(OC(=O)c7cc(O)c(O)c(O)c7)c6)[C@@H](OC(=O)c8cc(O)c(O)c(OC(=O)c9cc(O)c(O)c(O)c9)c8)[C@@H]3OC(=O)c%10cc(O)c(O)c(OC(=O)c%11cc(O)c(O)c(O)c%11)c%10 NIH, Spectrum, and Hit finder collection 79.79% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001486 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Cisplatin dichloroplatinum N.N.Cl[Pt]Cl NIH, Spectrum, and Hit finder collection 76.58% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001487 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA carboplatin cyclobutane-1,1-dicarboxylate platinum C1CC(C1)(C(=O)O)C(=O)O.N.N.[Pt] NIH, Spectrum, and Hit finder collection 73.75% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001488 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Theaflavin monogallates [(2R,3R)-5,7-dihydroxy-2-[3,4,5-trihydroxy-6-oxo-1-[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]benzo[7]annulen-8-yl]-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1C3=CC(=C(O)C4=C(O)C(=O)C=C(C=C34)[C@H]5Oc6cc(O)cc(O)c6C[C@H]5OC(=O)c7cc(O)c(O)c(O)c7)O NIH, Spectrum, and Hit finder collection 57.25% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001489 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Suramin 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate CC1=C(C=C(C(=O)NC2=CC=C(C=3C=C(C=C(C23)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C=C1)NC(C1=CC(=CC=C1)NC(NC1=CC(=CC=C1)C(NC1=C(C=CC(=C1)C(NC1=CC=C(C2=CC(=CC(=C12)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])=O)C)=O)=O)=O NIH, Spectrum, and Hit finder collection 50.83% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001490 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Gossypol-acetic acid complex 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde C(=O)C=1C(=C(C(=C2C=C(C(=C(C12)O)C1=C(C=C2C(=C(C(=C(C2=C1O)C=O)O)O)C(C)C)C)C)C(C)C)O)O NIH, Spectrum, and Hit finder collection 47.92%at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001491 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Hematein 4,6a,9,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-3-one Oc1cc2CC3(O)COC4=C(O)C(=O)C=CC4=C3c2cc1O NIH, Spectrum, and Hit finder collection 45.71% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001492 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Gossypol 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O NIH, Spectrum, and Hit finder collection 42.33% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001493 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA chlorophyllide Cu complex Na salt 3-[20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl-13-ethyl-3,7,12,17-tetramethyl-2,3-dihydroporphyrin-2,3-id-2-yl]propanoate CCC1=C2C=C3C(=C4C(=O)C(C(=C4[N-]3)C5=C(C(=C([N-]5)C=C6C(=C(C(=CC(=C1C)[N-]2)[N-]6)C=C)C)C)CCC(=O)[O-])C(=O)[O-])C.[Na+].[Na+].[Cu] NIH, Spectrum, and Hit finder collection 33.79% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001494 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Methacycline hydrochloride 4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide hydrochloride Cl.CN(C1C(C(=C(C2(C(C3=C(C4=C(C=CC=C4C(C3C(C12)O)=C)O)O)=O)O)O)C(=O)N)=O)C NIH, Spectrum, and Hit finder collection 33.33% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001495 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Sucralfate sodium [(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-bis(?1-alumanyloxysulfonyloxy)-2,5-bis(?1-alumanyloxysulfonyloxymethyl)oxolan-2-yl]oxy-3,5-bis(?1-alumanyloxysulfonyloxy)-6-(?1-alumanyloxysulfonyloxymethyl)oxan-4-yl]oxysulfonyloxyaluminum;hexadecahydrate O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Al]OS(=O)(=O)O[C@@H]1[C@](O[C@@H]([C@H]1OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])(COS(=O)(=O)O[Al])O[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al] NIH, Spectrum, and Hit finder collection 25.67% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001496 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Aurin tricarboxylic acid 5-[(3-carboxy-4-hydroxyphenyl)-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid OC(=O)c1cc(ccc1O)C(c2ccc(O)c(c2)C(O)=O)=C3C=CC(=O)C(=C3)C(O)=O NIH, Spectrum, and Hit finder collection 24.25% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001497 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Epigallocatechin 3,5-digallate (2R,3R)-7-hydroxy-5-(3,4,5-trihydroxybenzoyl)oxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate OC=1C=C(C(=O)O[C@H]2[C@H](OC3=CC(=CC(=C3C2)OC(C2=CC(=C(C(=C2)O)O)O)=O)O)C2=CC(=C(C(=C2)O)O)O)C=C(C1O)O NIH, Spectrum, and Hit finder collection 21.88% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001498 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Merbromin (2',7'-dibromo-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury(1+) Oc1cc2Oc3c([Hg+])c(O)c(Br)cc3C4(OC(=O)c5ccccc45)c2cc1Br NIH, Spectrum, and Hit finder collection 21.17% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001499 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of ATPase activity NA Sennoside a (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@@H]4c5cccc(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O NIH, Spectrum, and Hit finder collection 19.92% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001500 25299406 Hsp100 Hsp104 Yeast Cytosol Inhibition of chaperone activity NA Suramin 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate CC1=C(C=C(C(=O)NC2=CC=C(C=3C=C(C=C(C23)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C=C1)NC(C1=CC(=CC=C1)NC(NC1=CC(=CC=C1)C(NC1=C(C=CC(=C1)C(NC1=CC=C(C2=CC(=CC(=C12)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])=O)C)=O)=O)=O NIH, Spectrum, and Hit finder collection NA NA NA 10.1 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA NA HSPMDB001501 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 1 (S)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl acetyl-L-prolinate COC(=O)[C@H](COC(=O)[C@@H]1CCCN1C(C)=O)NC(=O)OCc2ccccc2 Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.016 ug/ml B. subtilis Bacterial infection HSPMDB001502 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 2 (2S,3S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutan-2-yl acetyl-L-prolinate COC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@H](C)OC(=O)[C@@H]2CCCN2C(C)=O Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml B. subtilis Bacterial infection HSPMDB001503 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 3 (2R,3S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutan-2-yl acetyl-L-prolinate COC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@@H](C)OC(=O)[C@@H]2CCCN2C(C)=O Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml B. subtilis Bacterial infection HSPMDB001504 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 (S)-2-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-3-methoxy-3-oxopropyl acetyl-L-prolinate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H](COC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OC Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001505 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 5 Methyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2-enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OC Fragments of a cyclic acyldepsipeptide NA NA NA NA NA NA NA NA NA NA NA NA NA NA 8 ug/ml B. subtilis Bacterial infection HSPMDB001506 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 (S)-2-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-3-methoxy-3-oxopropyl acetyl-L-prolinate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H](COC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001507 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 5 Methyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2-enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 8 ug/ml B. subtilis Bacterial infection HSPMDB001508 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 6 (2S,3S)-3-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-4-methoxy-4-oxobutan-2-yl acetyl-L-prolinate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]([C@H](C)OC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001509 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 (2R,3S)-3-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-4-methoxy-4-oxobutan-2-yl acetyl?L-prolinate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]([C@@H](C)OC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001510 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 8 Methyl (S,E)-2-(3-cyclohexylacrylamido)-3-(3,5-difluorophenyl)propanoate COC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)/C=C/C2CCCCC2 N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001511 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 9 Methyl (S)-3-(3,5-difluorophenyl)-2-((2E,4E,6E)-octa-2,4,6-trienamido)propanoate COC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)\C=C\C=C\C=C\C N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001512 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 10 Methyl (2S)-3-(3,5-difluorophenyl)-2-((E)-5-methylhept-2-enamido)propanoate CCC(C)C/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 8 ug/ml B. subtilis Bacterial infection HSPMDB001513 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 11 Methyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2?enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA >128 ug/ml B. subtilis Bacterial infection HSPMDB001514 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 12 Methyl (S)-2-(3-cyclohexylpropanamido)-3-(3,5-difluorophenyl)propanoate COC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)CCC2CCCCC2 N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml B. subtilis Bacterial infection HSPMDB001515 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 13 Methyl (E)-hept-2-enoyl-L-phenylalaninate CCCC/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml B. subtilis Bacterial infection HSPMDB001516 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 14 Methyl (E)-hept-2-enoyl-L-leucinate CCCC/C=C/C(=O)N[C@@H](CC(C)C)C(=O)OC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA >128 ug/ml B. subtilis Bacterial infection HSPMDB001517 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 15 3-(3,5-difluorophenyl)-2-[(2E)-hex-2-enamido]propanoic acid CCC/C=C/C(=O)NC(Cc1cc(F)cc(F)c1)C(O)=O N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml B. subtilis Bacterial infection HSPMDB001518 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 16 (S,E)-N-(1-amino-3-(3,5-difluorophenyl)-1-oxopropan-2-yl)hept-2-enamide CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(N)=O N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001519 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 17 (S,E)-N-(3-(3,5-difluorophenyl)-1-(methylamino)-1-oxopropan-2-yl)hept-2-enamide CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)NC N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001520 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 18 (S,E)-N-(3-(3,5-difluorophenyl)-1-(dimethylamino)-1-oxopropan-2-yl)hept-2-enamide CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N(C)C N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml B. subtilis Bacterial infection HSPMDB001521 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 19 (furan-2-yl)methyl (2S)-3-(3,5-difluorophenyl)-2-[(2E)-hex-2-enamido]propanoate CCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCc2occc2 N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml B. subtilis Bacterial infection HSPMDB001522 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 20 Benzyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2?enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCc2ccccc2 N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA >128 ug/ml B. subtilis Bacterial infection HSPMDB001523 25212124 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 21 Prop-2-yn-1-yl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2-enamido)propanoate CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCC#C N-acyldifluorophenylalanine fragment analogue NA NA NA NA NA NA NA NA NA NA NA NA NA NA 2 ug/ml B. subtilis Bacterial infection HSPMDB001524 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 1 (3Z)-3-[3-(4-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5- ylidene]-5-nitro-1,3-dihydro-2H-indol-2-one [O-][N+](=O)c1ccc2NC(=O)\C(=C3/SC(=S)N(C3=O)c4ccc(Cl)cc4)c2c1 MyriaScreen diversity collection NA NA NA 10 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001525 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 2 (5Z)-5-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-phenyl1,3-thiazolidine-2,4-dione Brc1ccc2NC(=O)C(=C/3SC(=O)N(C3=O)c4ccccc4)/c2c1 MyriaScreen diversity collection NA NA NA 30 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001526 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA NA NA 7 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001527 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 4 3,4-Dichloro-N-(3-nitrophenyl)-1-benzothiophene-2-carboxamide [O-][N+](=O)c1cccc(NC(=O)c2sc3cccc(Cl)c3c2Cl)c1 MyriaScreen diversity collection NA NA NA 90 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001528 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 5 (4Z)-1-(4-Chlorophenyl)-4-{4-[(4-fluorobenzyl)oxy]-3- methoxybenzylidene}-3,5-pyrazolidinedione COc1cc(ccc1OCc2ccc(F)cc2)/C=C3/C(=O)NN(C3=O)c4ccc(Cl)cc4 MyriaScreen diversity collection NA NA NA 7.5 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001529 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA NA NA 20 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001530 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 7 (3Z)-3-(3-Allyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3- dihydro-2H-indol-2-one C=CCN1C(=S)S\C(C1=O)=C2/C(=O)Nc3ccccc23 MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001531 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 8 2-(4-Chloro-5-methyl-3-nitro-1H-pyrazol-1-yl)-N-[3-(2,4- dichlorophenoxy)-5-nitrophenyl]acetamide Cc1n(CC(=O)Nc2cc(Oc3ccc(Cl)cc3Cl)cc(c2)[N+]([O-])=O)nc(c1Cl)[N+]([O-])=O MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001532 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 9 2-[(5Z)-5-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2- thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid CC(C)C(N1C(=S)SC(/C1=O)=C/2C(=O)Nc3ccc(Br)cc23)C(O)=O MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001533 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 10 1-Ethyl-4-hydroxy-N-(3-hydroxyphenyl)-2-oxo-1,2-dihydro-3- quinolinecarboxamide CCN1C(=O)C(=C(O)c2ccccc12)C(=O)Nc3cccc(O)c3 MyriaScreen diversity collection NA NA NA 65 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001534 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 11 (1E,3E,5E)-N,N'-Diphenyl-1,3,5-hexatriene-1,6-diamine hydrochloride (1:1) Cl.N(\C=C\C=C\C=C\Nc1ccccc1)c2ccccc2 MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001535 23961953 Hsp100 ClpB Bacteria Cytosol Inhibition of chaperone activity NA 12 (3Z)-5-Bromo-3-[3-(3-methoxypropyl)-4-oxo-2-thioxo-1,3- thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one COCCCN1C(=S)SC(/C1=O)=C/2C(=O)Nc3ccc(Br)cc23 MyriaScreen diversity collection NA NA NA >100 NA NA NA NA Nucleotide binding domain Luciferase aggregate reactivation assay NA NA NA NA NA NA Bacterial infection HSPMDB001536 23961953 Hsp100 ClpB Bacteria Cytosol NA Antibacterial activity 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 60-100 uM E. coli strains MC4100 Bacterial infection HSPMDB001537 23961953 Hsp100 ClpB Bacteria Cytosol NA Antibacterial activity 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 60-100 uM E. coli strains MC4100 Bacterial infection HSPMDB001538 23961953 Hsp100 NA Human NA NA Antiproliferative activity 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA 30-50% MTT viability assay NA NA NA HeLa Bacterial infection HSPMDB001539 23961953 Hsp100 NA Human NA NA Antiproliferative activity 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA 30-50% MTT viability assay NA NA NA HeLa Bacterial infection HSPMDB001540 23961953 Hsp100 NA Human NA NA Antiproliferative activity 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA 30-50% MTT viability assay NA NA NA CHO Bacterial infection HSPMDB001541 23961953 Hsp100 NA Human NA NA Antiproliferative activity 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA NA NA NA NA NA NA NA NA NA 30-50% MTT viability assay NA NA NA CHO Bacterial infection HSPMDB001542 23961953 Hsp100 ClpB Bacteria Cytosol Binding affinity NA 3 5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O MyriaScreen diversity collection NA 12.9 NA NA NA NA NA NA NA Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001543 23961953 Hsp100 ClpB Bacteria Cytosol Binding affinity NA 6 2-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamate Clc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1Cl MyriaScreen diversity collection NA 19 NA NA NA NA NA NA NA Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001544 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.125 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001545 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.25 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001546 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001547 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001548 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001549 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001550 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 4 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001551 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 16 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001552 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.125 ug/ml L. monocytogenes Bacterial infection HSPMDB001553 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ADEPA1 (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001554 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001555 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001556 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001557 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001558 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001559 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001560 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001561 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001562 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml L. monocytogenes Bacterial infection HSPMDB001563 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001564 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001565 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001566 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001567 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001568 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001569 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001570 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001571 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 16 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001572 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml L. monocytogenes Bacterial infection HSPMDB001573 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP2 3-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acid C[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001574 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001575 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001576 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001577 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001578 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001579 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001580 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001581 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001582 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml L. monocytogenes Bacterial infection HSPMDB001583 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP3 [4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanone ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001584 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 4 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001585 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 32 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001586 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001587 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001588 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001589 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001590 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001591 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 8 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001592 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml L. monocytogenes Bacterial infection HSPMDB001593 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP4 ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=O LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 128 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001594 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001595 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001596 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001597 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001598 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001599 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001600 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001601 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. pneumoniae (ATCC 49619) Bacterial infection HSPMDB001602 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml L. monocytogenes Bacterial infection HSPMDB001603 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP5 ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate [H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1 LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001604 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001605 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 64 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001606 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001607 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001608 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001609 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001610 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001611 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1a 2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001612 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml N. gonorrhoeae (N.279) Bacterial infection HSPMDB001613 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA 16 ug/ml N. meningitidis (MC58) Bacterial infection HSPMDB001614 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml H. influenzae (H2192) Bacterial infection HSPMDB001615 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml E. coli Bacterial infection HSPMDB001616 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. typhimurium (SL1344) Bacterial infection HSPMDB001617 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml P. aeruginosa (PAO1) Bacterial infection HSPMDB001618 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml S. aureus (ATCC 29213) Bacterial infection HSPMDB001619 21944755 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA NA NA NA NA NA NA NA NA NA NA NA NA NA >256 ug/ml M. smegmatis (mc2155) Bacterial infection HSPMDB001620 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1A (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.3,n=14.6 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001621 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1B (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.7, n=11.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001622 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 3.2, n=16.1 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001623 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1A (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.3, n=15.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001624 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1B (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.7, n=11.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001625 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 3.3, n=16.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001626 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1A (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.4, n=14.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001627 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1B (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 0.7, n=14.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001628 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ACP1b N-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide CC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 4.1, n=14.0 NA NA NA NA NA NA Nucleotide binding domain Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Bacterial infection HSPMDB001629 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1A (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 1.1 NA NA NA NA NA NA Nucleotide binding domain Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001630 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ADEP1B (2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide [H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\C LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 1.4 NA NA NA NA NA NA Nucleotide binding domain Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001631 21944755 Hsp100 ClpP Bacteria Cytosol Binding affinity NA ACP1 N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamide CC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)F LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSet NA 128 NA NA NA NA NA NA Nucleotide binding domain Surface plasmon resonance (SPR) NA NA NA NA NA NA Bacterial infection HSPMDB001632 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 334 5,11-Dihydro-11-(3-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Oc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001633 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 358 5,11-Dihydro-11-(3-bromo-5-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin12-one Oc1cc(Br)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001634 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 369 2-(3-hydroxyphenyl)-17-oxo-N-(prop-2-yn-1-yl)-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide OC=1C=C(C=CC1)[S]1C=2C(C3=CC(=CC=C3C2NC=2C=CC=CC12)C(=O)NCC#C)=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001635 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 344 5,11-Dihydro-11-(3-hydroxy-5-methoxyphenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one COc1cc(O)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001636 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 347 5,11-Dihydro-11-(3,5-dihydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Oc1cc(O)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001637 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 336 10-(thiophen-2-yl)-9-thia-2-azatetracyclo[9.7.0.0³,?.0¹³,¹?]octadeca-1(11),3(8),4,6,13(18),14,16-heptaen-12-one O=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5sccc5 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001638 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 376 N-{2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethyl}-2-(3-hydroxyphenyl)-17-oxo-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide C(CC#C)C1(N=N1)CCNC(=O)C1=CC=C2C=3NC=4C=CC=CC4[S](C3C(C2=C1)=O)C1=CC(=CC=C1)O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001639 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 348 11-(3-Fluorophenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Fc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001640 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 366 2,3-Dichloro-5,11-dihydro-11-(3-hydroxyphenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one Oc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5cc(Cl)c(Cl)cc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001641 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 350 5,11-Dihydro-11-(3-hydroxy-5-(hex-5-ynyloxy)-phenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one Oc1cc(OCCCCC#C)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001642 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 353 4-{12-oxo-9-thia-2-azatetracyclo[9.7.0.0³,?.0¹³,¹?]octadeca-1(11),3(8),4,6,13(18),14,16-heptaen-10-yl}phenyl formate O=COc1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001643 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 356 2-Ethynyl-5,11-dihydro-11-(3-hydroxyphenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one Oc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5cc(ccc45)C#C Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001644 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 340 5,11-Dihydro-11-phenyl-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one O=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5ccccc5 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001645 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 343 5,11-Dihydro-11-(4-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Oc1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001646 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 341 5,11-Dihydro-11-(3-methoxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one COc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001647 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 368 2-(3-hydroxyphenyl)-17-oxo-N-(prop-2-yn-1-yl)-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-13-carboxamide OC=1C=C(C=CC1)[S]1C=2C(C3=CC=C(C=C3C2NC=2C=CC=CC12)C(=O)NCC#C)=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001648 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 359 5,11-Dihydro-11-(3-aminophenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Nc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001649 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 370 2-(3-hydroxyphenyl)-17-oxo-N-(prop-2-yn-1-yl)-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-13-carboxamide OC=1C=C(C=CC1)[S]1C=2C(C3=CC=C(C=C3C2NC=2C=CC=CC12)C(=O)NCC#C)=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001650 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 351 5,11-Dihydro-11-(2-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Oc1ccccc1C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001651 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 367 5,11-Dihydro-11-(3-(hydroxymethyl)phenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin12-one OCc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001652 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 355 11-(3-hydroxyphenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10- dioxide Oc1cccc(c1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001653 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 352 10-(pyridin-2-yl)-9-thia-2-azatetracyclo[9.7.0.0³,?.0¹³,¹?]octadeca-1(11),3(8),4,6,13(18),14,16-heptaen-12-one O=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5ccccn5 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001654 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 345 5,11-Dihydro-11-(3-hydroxyphenyl)-8-methoxy-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-one COc1ccc2NC3=C(C(Sc2c1)c4cccc(O)c4)C(=O)c5ccccc35 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001655 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 346 11-(4-Fluorophenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one Fc1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001656 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 349 11-(4-Carboxyphenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one OC(=O)c1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001657 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 360 11-(4-(trifluoromethyl)phenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one FC(F)(F)c1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001658 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 354 11-(4-fluorophenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10-dioxide Fc1ccc(cc1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001659 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 374 N-{2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethyl}-2-(3-methoxyphenyl)-17-oxo-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide [H]C1=C(C=C2C(=O)C3=C(NC4=C(C=CC=C4)[S]3C3=CC=CC(OC)=C3)C2=C1)C(=O)NCCC1(CCC#C)N=N1 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001660 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 362 11-(3-methoxyphenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10- dioxide COc1cccc(c1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001661 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 364 11-(4-(trifluoromethyl)phenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10-dioxide FC(F)(F)c1ccc(cc1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=O Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001662 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 363 11-([1,1'-biphenyl]-4-yl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10- dioxide O=C1c2ccccc2C3=C1C(c4ccc(cc4)c5ccccc5)[S](=O)(=O)c6ccccc6N3 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001663 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 365 11-([1,1'-biphenyl]-4-yl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one O=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5ccc(cc5)c6ccccc6 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001664 28906057 Hsp100 ClpX Bacteria Cytosol Inhibition of protease activity NA 375 N-{2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethyl}-2-(3-methoxyphenyl)-17-oxo-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide [H]C1=C(C=C2C(=O)C3=C(NC4=C(C=CC=C4)[S]3C3=CC=CC(OC)=C3)C2=C1)C(=O)NCCC1(CCC#C)N=N1 Synthetic chemical compounds NA NA NA <50 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP) NA NA NA NA NA NA Bacterial infection HSPMDB001665 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 2 Trans 4-butyl 3-pentyloxetan-2-one CCCCC[C@H]1[C@H](CCCC)OC1=O Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 250 ug/ml M. smegmatis (mc2155) Tuberculosis HSPMDB001666 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 3 Trans-4-butyl 3-heptyloxetan-2-one CCCCCCC[C@H]1[C@H](CCCC)OC1=O Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 150 ug/ml M. smegmatis (mc2155) Tuberculosis HSPMDB001667 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-one CCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 45 ug/ml M. smegmatis (mc2155) Tuberculosis HSPMDB001668 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2 Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 10 ug/ml M. smegmatis (mc2155) Tuberculosis HSPMDB001669 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-one CCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 47 ug/ml M. tuberculosis (H37Rv) Tuberculosis HSPMDB001670 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2 Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 28 ug/ml M. tuberculosis (H37Rv) Tuberculosis HSPMDB001671 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 3 Trans-4-butyl 3-heptyloxetan-2-one CCCCCCC[C@H]1[C@H](CCCC)OC1=O Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >800 ug/ml S. coelicolor Bacterial infection HSPMDB001672 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-one CCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >800 ug/ml S. coelicolor Bacterial infection HSPMDB001673 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2 Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >800 ug/ml S. coelicolor Bacterial infection HSPMDB001674 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 3 Trans-4-butyl 3-heptyloxetan-2-one CCCCCCC[C@H]1[C@H](CCCC)OC1=O Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 650 ug/ml S. griseus Bacterial infection HSPMDB001675 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-one CCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 580 ug/ml S. griseus Bacterial infection HSPMDB001676 24047344 Hsp100 ClpP Bacteria Cytosol NA Antibacterial activity 7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2 Beta lactone analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA 250 ug/ml S. griseus Bacterial infection HSPMDB001677 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA 2.4 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001678 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA Ac-His-Lys-boroMet NA NA Boronate compounds NA NA 6.8 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001679 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA 2.1 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001680 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA 1.46 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001681 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA 0.96 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001682 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA 1.7 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001683 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA 4.2 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001684 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA 5.8 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001685 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.9 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001686 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA 2.4 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001687 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.75 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001688 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA 0.34 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001689 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA 0.4 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001690 25759383 Hsp100 ClpP1P2 Human Mitochondria Inhibition of peptidase activity NA N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA 11.6 NA NA NA NA NA NA Peptide specific clevage assay NA NA NA NA NA NA Tuberculosis HSPMDB001691 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA 0.46 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001692 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA Ac-His-Lys-boroMet NA NA Boronate compounds NA NA 0.78 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001693 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA 0.8 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001694 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA 3.2 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001695 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA 0.18 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001696 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA 0.24 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001697 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA 0.82 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001698 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA 0..34 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001699 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.23 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001700 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.18 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001701 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA 0.0625 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001702 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA 0.29 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001703 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA 0.12 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001704 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of peptidase activity NA N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA 13 NA NA NA NA NA Nucleotide binding domain Peptide specific clevage assay NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB001705 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 12 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001706 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-His-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 6 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001707 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 3 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001708 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 12 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001709 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 3 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001710 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 3 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001711 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 24 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001712 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 6 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001713 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 3 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001714 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 6 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001715 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 7 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001716 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 12 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001717 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 13 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001718 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA 200 uM M. tuberculosis (H37Rv) Tuberculosis HSPMDB001719 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001720 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-His-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001721 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001722 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001723 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001724 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001725 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001726 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001727 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001728 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001729 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001730 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001731 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001732 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM E. coli Bacterial infection HSPMDB001733 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001734 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-His-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001735 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ac-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001736 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Ala(1-naphtyl)-Lys-boroLeu NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001737 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Trp-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001738 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Ala-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001739 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Pro-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001740 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Picolinoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001741 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(3-Phenyl)propanoyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001742 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Benzyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001743 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001744 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001745 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001746 25759383 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity N-(Phenylmetanesulfonyl)-Lys-boroMet NA NA Boronate compounds NA NA NA NA NA NA NA NA NA NA NA Resazurin based viability assay NA NA >200 uM S. aureus Bacterial infection HSPMDB001747 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of protease activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA 0.14 NA NA NA NA Nucleotide binding domain Peptidase assay (Ac-PKM-amc) NA NA NA NA NA NA Tuberculosis HSPMDB001748 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of protease activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA 5.8 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Tuberculosis HSPMDB001749 25759383 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of protease activity NA N-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMet NA NA Boronate compounds NA NA NA 3.2 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Tuberculosis HSPMDB001750 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 6.99 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001751 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA AV176 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 1.54 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001752 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA TG42 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 0.39 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001753 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA TG43 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 0.57 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001754 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA TG53 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 0.33 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001755 30109319 Hsp100 hClpP Human Mitochondria Inhibition of peptidase activity NA TG54 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 1.49 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB001756 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 4.01 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001757 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 1.44 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001758 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA TG42 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001759 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA TG43 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001760 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA TG53 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001761 30109319 Hsp100 hClpP Bacteria Cytosol Inhibition of peptidase activity NA TG54 4-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetate O=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5 Naphthofuran derivative with 8-methoxynaphthofuran moiety NA NA NA 2.74 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001762 24022489 Hsp100 ClpC1 Bacteria Cytosol Binding affinity NA CymA1 (3S,6S,9S,12S,15S,18S,21S)-3-[(R)-[1-[(3S)-4-(3-aminopropylamino)-3-hydroxy-2-methylbutan-2-yl]indol-3-yl]-hydroxymethyl]-21-[(2R)-3-hydroxy-2-methylpropyl]-15-[(R)-methoxy(phenyl)methyl]-1,10,18-trimethyl-6-[(2R)-4-methylpent-3-en-2-yl]-9-(2-methylpropyl)-12-propan-2-yl-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptone CC1C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)CO)C)C(C2=CN(C3=CC=CC=C32)C(C)(C)C(CNCCCN)O)O)C(C)C=C(C)C)CC(C)C)C)C(C)C)C(C4=CC=CC=C4)OC Cyclomarine A (CymA) derivative NA 0.012 NA NA NA NA NA NA NA Isothermal titration calorimetry (ITC) NA NA NA NA NA NA Tuberculosis HSPMDB001763 24022489 Hsp100 ClpC1 Bacteria Cytosol NA Antibacterial activity CymA1 (3S,6S,9S,12S,15S,18S,21S)-3-[(R)-[1-[(3S)-4-(3-aminopropylamino)-3-hydroxy-2-methylbutan-2-yl]indol-3-yl]-hydroxymethyl]-21-[(2R)-3-hydroxy-2-methylpropyl]-15-[(R)-methoxy(phenyl)methyl]-1,10,18-trimethyl-6-[(2R)-4-methylpent-3-en-2-yl]-9-(2-methylpropyl)-12-propan-2-yl-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptone CC1C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)CO)C)C(C2=CN(C3=CC=CC=C32)C(C)(C)C(CNCCCN)O)O)C(C)C=C(C)C)CC(C)C)C)C(C)C)C(C4=CC=CC=C4)OC Cyclomarine A (CymA) derivative NA NA NA NA NA NA NA NA NA NA 50% Bacterial growth inhibition assay (OD based) NA NA 1.2 uM M. smegmatis (mc2155) Tuberculosis HSPMDB001764 24022489 Hsp100 ClpC1 Bacteria Cytosol NA Antibacterial activity CymA1 (3S,6S,9S,12S,15S,18S,21S)-3-[(R)-[1-[(3S)-4-(3-aminopropylamino)-3-hydroxy-2-methylbutan-2-yl]indol-3-yl]-hydroxymethyl]-21-[(2R)-3-hydroxy-2-methylpropyl]-15-[(R)-methoxy(phenyl)methyl]-1,10,18-trimethyl-6-[(2R)-4-methylpent-3-en-2-yl]-9-(2-methylpropyl)-12-propan-2-yl-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptone CC1C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)CO)C)C(C2=CN(C3=CC=CC=C32)C(C)(C)C(CNCCCN)O)O)C(C)C=C(C)C)CC(C)C)C)C(C)C)C(C4=CC=CC=C4)OC Cyclomarine A (CymA) derivative NA NA NA NA NA NA NA NA NA NA 50% Bacterial growth inhibition assay (OD based) NA NA 0.28 uM M. bovis Tuberculosis HSPMDB001765 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 10 Benzyl (1-(Diphenoxyphosphoryl)-2-phenylethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=CC=C4 Serine protease inhibitor library 7% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001766 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 11 Benzyl (1-(Diphenoxyphosphoryl)-2-(p-tolyl)ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(C)C=C4 Serine protease inhibitor library 7% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001767 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 12 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-methoxyphenyl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(OC)C=C4 Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001768 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 13 Benzyl (Benzofuran-5-yl(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3OC=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 6% at 200uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001769 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 14 Benzyl (1-(Diphenoxyphosphoryl)-2-(naphthalen-2-yl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C5C=CC=CC5=C4 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001770 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 15 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-fluorophenyl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(F)C=C4 Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001771 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 16 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamate O=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library 100% at 200 uM NA NA 14.2 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001772 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 17 Benzyl (1-(Diphenoxyphosphoryl)-3-(methylthio)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCSC Serine protease inhibitor library 9% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001773 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 18 Benzyl ((Diphenoxyphosphoryl)(6-hydroxynaphthalen-2-yl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C5C=C(O)C=CC5=C4 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001774 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 21 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-hydroxyphenyl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001775 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 22 Benzyl (1-(Diphenoxyphosphoryl)-2-(3-hydroxyphenyl)ethyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=CC(O)=C4 Serine protease inhibitor library 3% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001776 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 23 Benzyl (1-((4-Acetamidobenzyl)(4-acetamidophenoxy)-phosphoryl)-2-phenylethyl)carbamate O=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(CC2=CC=C(NC(C)=O)C=C2)=O)CC3=CC=CC=C3)NCC4=CC=CC=C4 Serine protease inhibitor library 9% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001777 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 Benzyl (1-(Hydroxy(phenoxy)phosphoryl)-2-(4-hydroxyphenyl)-ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(O)=O)CC3=CC=C(O)C=C3 Serine protease inhibitor library 11% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001778 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 25 Benzyl (2-(4-Hydroxyphenyl)-1-(methoxy(phenoxy)phosphoryl)-ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC)=O)CC3=CC=C(O)C=C3 Serine protease inhibitor library 14% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001779 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 Benzyl (S)-(1-Cyano-2-(4-hydroxyphenyl)ethyl)carbamate O=C(OCC1=CC=CC=C1)N[C@H](C#N)CC2=CC=C(O)C=C2 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001780 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 Benzyl (S)-(1-Cyano-2-phenylethyl)carbamate O=C(OCC1=CC=CC=C1)N[C@H](C#N)CC2=CC=CC=C2 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001781 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 Benzyl ((2S)-1-((1-(Diphenoxyphosphoryl)-2-(4-hydroxyphenyl)-ethyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4)=O Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001782 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 36 Benzyl ((2S)-6-Amino-1-((1-(diphenoxyphosphoryl)-3-(methylthio)propyl)amino)-1-oxohexan-2-yl)carbamate Hydrochloride O=C(OCC1=CC=CC=C1)N[C@@H](CCCCN)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCSC)=O.[H]Cl Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001783 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 41 Benzyl ((S)-1-(((S)-1-Cyano-2-(4-hydroxyphenyl)ethyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@H](C#N)CC2=CC=C(O)C=C2)=O Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001784 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 42 Diphenyl ((1-Carbamimidoy l p i p e r i d i n - 4 - y l ) ( 2 - ( 4 -methoxyphenyl)acetamido)methyl)phosphonate 2,2,2-trifluoroacetate O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)CC4=CC=C(OC)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001785 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 43 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(nicotinamido)-methyl)phosphonate 2,2,2-trifluoroacetate O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)C4=CN=CC=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001786 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 44 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(furan-2-carboxamido)methyl)phosphonate 2,2,2-trifluoroacetate O=C(C1=CC=CO1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4CCN(C(N)=N)CC4.O=C(O)C(F)(F)F Serine protease inhibitor library 24% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001787 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 45 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(cinnamamido)-methyl)phosphonate Bis(2,2,2-trifluoroacetate) O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)/C=C/C4=CC=CC=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F Serine protease inhibitor library 18% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001788 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 46 D i p h e n y l ( ( 1 - C a rbami m i d o y l p i p e r i d i n - 4 - y l ) ( 2 -phenoxyethylsulfonamido)methyl)phosphonate 2,2,2-trifluoroacetate O=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)(CCOC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 27% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001789 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 47 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(3-(piperidin-4-yl)-propanamido)methyl)phosphonate bis(2,2,2-trifluoroacetate) O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)CCC4CCNCC4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001790 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 48 Diphenyl (E)-Diphenyl ((3-(Benzo[d][1,3]dioxol-5-yl)acrylamido)-(1-carbamimidoylpiperidin-4-yl)methyl)phosphonate 2,2,2-Trifluoroacetate NC(N1CCC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC(/C=C/C4=CC=C(OCO5)C5=C4)=O)CC1)=N.O=C(O)C(F)(F)F Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001791 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 49 Diphenyl ((3-(Benzo[d][1,3]dioxol-5-yl)propiolamido)(1-carbamimidoylpiperidin-4-yl)methyl)phosphonate NC(N1CCC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC(C#CC4=CC=C(OCO5)C5=C4)=O)CC1)=N Serine protease inhibitor library 24% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001792 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 50 Diphenyl ((1-Carbamimidoylpiperidin-4-yl)((5-phenylpyrimidin-2-yl)amino)methyl)phosphonate 2,2,2-trifluoroacetate NC(N1CCC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC4=NC=C(C5=CC=CC=C5)C=N4)CC1)=N.O=C(O)C(F)(F)F Serine protease inhibitor library 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001793 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 51 (Z)-Diphenyl ((1-Carbamimidoylpiperidin - 4 - y l ) ( 3 -phenylacrylamido)methyl)phosphonate 2,2,2-Trifluoroacetate O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)/C=C\C4=CC=CC=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 11% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001794 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 52 Methyl (1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)-carbamate O=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3 Serine protease inhibitor library 27% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001795 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 53 Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonate C[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=O Serine protease inhibitor library 90% at 200 uM NA NA 49.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001796 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 54 P e n t - 4 - y n - 1 - y l ( 1 - ( d i p h e n o x y p h o s p h o r y l ) - 2 - ( 4 -guanidinophenyl)ethyl)carbamate O=C(OCCCC#C)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3 Serine protease inhibitor library 23% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001797 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 55 2-(2-Azidoethoxy)ethyl (1-(diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)carbamate O=C(OCCOCCN=[N+]=[N-])NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3 Serine protease inhibitor library 68% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001798 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 56 (Perfluorophenyl)methyl (1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)carbamate 2,2,2-Trifluoroacetate O=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4 Serine protease inhibitor library 25% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001799 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 57 3,3,4,4,5,5,6,6,7,8,8,8-Dodecafluoro-7-(trifluoromethyl)octyl 1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethylcarbamate2,2,2-Trifluoroacetate O=C(OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(C(F)(F)F)(F)C(F)(F)F)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3.O=C(O)C(F)(F)F Serine protease inhibitor library 55% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001800 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 58 Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 96% at 200 uM NA NA 39.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001801 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 59 2-Phenoxyethyl ((4-Aminophenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCCOC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001802 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 60 4,4,4-Trifluorobutyl ((4-Aminophenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCCCC(F)(F)F)NC(C1=CC=C(N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001803 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 61 ( P e r fl u o r o p h e n y l ) m e t h y l ( ( 4 - A m i n o p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 28% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001804 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 62 Diphenyl ((4-Guanidinophenyl)((4-(trifluoromethyl)phenyl)-sulfonamido)methyl)phosphonate O=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(N)=N)C=C3)(C4=CC=C(C(F)(F)F)C=C4)=O Serine protease inhibitor library 27% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001805 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 63 Diphenyl ((4-Guanidinophenyl)(phenylsulfonamido)methyl)-phosphonate O=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(N)=N)C=C3)(C4=CC=CC=C4)=O Serine protease inhibitor library 29% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001806 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 64 (Perfluorophenyl)methyl ((Diphenoxyphosphoryl)(4-guanidinophenyl)methyl)carbamate O=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(NC(N)=N)C=C4 Serine protease inhibitor library 48% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001807 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 65 Methyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)-phenyl)methyl)carbamate O=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(C(F)(F)F)=O)C=C3 Serine protease inhibitor library 64% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001808 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 66 Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5 Serine protease inhibitor library 93% at 200 uM NA NA 8.2 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001809 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 67 2-Ami n o e t h y l ((Diphenoxyphosph o r y l ) ( 4 - ( 2 , 2 , 2 -trifluoroacetamido)phenyl)methyl)carbamate 2,2,2-Trifluoroacetate O=C(OCCN)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(C(F)(F)F)=O)C=C3.O=C(O)C(F)(F)F Serine protease inhibitor library 73% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001810 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 68 B e n z y l 2 - ( 4 - ( 3 , 3 - D i m e t h y l u r e i d o ) p h e n y l ) - 1 -(diphenoxyphosphoryl)ethylcarbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N(C)C)=O)C=C4 Serine protease inhibitor library 9% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001811 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 69 Benzyl ((4-(2-Aminoethoxy)phenyl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(OCCN)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001812 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 70 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library 100% at 200 uM NA NA 13.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001813 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 71 Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library 93% at 200 uM NA NA 48.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001814 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 72 Methyl ((Diphenoxyphosphoryl)(5-nitronaphthalen-1-yl)-methyl)carbamate O=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=C4C=CC=C([N+]([O-])=O)C4=CC=C3 Serine protease inhibitor library 17% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001815 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 73 Diphenyl ((1-Carbamimidoylazetidin-3-yl)(pyrimidin-2-ylamino)methyl)phosphonate 2,2,2-trifluoroacetate NC(N1CC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC4=NC=CC=N4)C1)=N.O=C(O)C(F)(F)F Serine protease inhibitor library 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001816 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 74 Diphenyl ((3-(N-Hydroxycarbamimidoyl)phenyl)(pyrimidin-2-ylamino)methyl)phosphonate N=C(C1=CC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC4=NC=CC=N4)=CC=C1)NO Serine protease inhibitor library 23% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001817 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 75 2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethyl (Diphenoxyphosphoryl)(4-(piperazin-1-yl)phenyl)methylcarbamate 2,2,2-Trifluoroacetate O=C(O)C(F)(F)F.O=C(OCCOCCOCC#C)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(N4CCNCC4)C=C3 Serine protease inhibitor library 25% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001818 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 76 Benzyl (1-(Diphenoxyphosphoryl)-4-guanidinobutyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCCNC(N)=N Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001819 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 77 Benzyl (Benzo[d][1,3]dioxol-5-yl(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(OCO3)C3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001820 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 78 Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 100% at 200 uM NA NA 0.6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001821 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 79 Benzyl ((Diphenoxyphosphoryl)(pyridin-3-yl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=CN=C4 Serine protease inhibitor library 27% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001822 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 80 Benzyl ((Diphenoxyphosphoryl)(3-nitrophenyl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=CC([N+]([O-])=O)=C4 Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001823 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 81 Benzyl (1-(Diphenoxyphosphoryl)ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C Serine protease inhibitor library 3% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001824 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 82 Benzyl (1-(Diphenoxyphosphoryl)-3-methylbutyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC(C)C Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001825 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 83 Benzyl ((Diphenoxyphosphoryl)(4-guanidinophenyl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(NC(N)=N)C=C4 Serine protease inhibitor library 29% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001826 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 84 Benzyl (2-(Benzyloxy)-1-(diphenoxyphosphoryl)ethyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)COCC4=CC=CC=C4 Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001827 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 100% at 200 uM NA NA 0.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001828 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 86 Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4 Serine protease inhibitor library 100% at 200 uM NA NA 38 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001829 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 87 Benzyl ((2-Chloro-5-nitrophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC([N+]([O-])=O)=CC=C2Cl)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001830 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 88 Benzyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(C(N)=N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 30% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001831 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 89 Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 88% at 200 uM NA NA 100.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001832 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 81% at 200 uM NA NA 79.7 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001833 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 91 Benzyl ((Diphenoxyphosphoryl)(4-nitrophenyl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library 71% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001834 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 92 Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 100% at 200 uM NA NA 0.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001835 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 93 Benzyl (1-(Diphenoxyphosphoryl)-3-phenylpropyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=CC=C4 Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001836 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 94 Benzyl ((Diphenoxyphosphoryl)(naphthalen-1-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=C5C=CC=CC5=CC=C4 Serine protease inhibitor library 6% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001837 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 95 Benzyl ((Diphenoxyphosphoryl)(naphthalen-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C5C=CC=CC5=C4 Serine protease inhibitor library 51% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001838 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 96 Benzyl ((3-Cyanophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C#N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001839 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 97 B e n z y l ( ( 4 - ( D i m e t h y l a m i n o) n a p h t h a l e n - 1 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=C3C=CC=CC3=C(N(C)C)C=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001840 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 98 Benzyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)-phenyl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(NC(C(F)(F)F)=O)C=C4 Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001841 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 107 Benzyl ((Diphenoxyphosphoryl)(4-(piperazin-1-yl)phenyl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 100% at 200 uM NA NA 0.6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001842 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 108 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N3CCNCC3)C(C#N)=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 10% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001843 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 109 Benzyl ((Diphenoxyphosphoryl)(piperidin-4-yl)methyl)-carbamate 2,2,2-Trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4CCNCC4.O=C(O)C(F)(F)F Serine protease inhibitor library 30% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001844 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 110 Benzyl 1-(Diphenoxyphosphoryl)-2-(piperidin-4-yl)-ethylcarbamate 2,2,2-Trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4CCNCC4.O=C(O)C(F)(F)F Serine protease inhibitor library 16% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001845 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 111 Benzyl ((4-(Aminomethyl)cyclohexyl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-Trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CCC(CN)CC2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001846 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 114 Benzyl ((6-Aminonaphthalen-2-yl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library <1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001847 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library 100% at 200 uM NA NA 71.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001848 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 116 Benzyl 2-(4-Acetamidophenyl)-1-(diphenoxyphosphoryl)-ethylcarbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(C)=O)C=C4 Serine protease inhibitor library 18% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001849 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 117 Benzyl ((Diphenoxyphosphoryl)(5-nitronaphthalen-1-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=C5C=CC=C([N+]([O-])=O)C5=CC=C4 Serine protease inhibitor library 49% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001850 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 118 B e n z y l ( ( 4 - ( D i m e t h y l a m i n o ) - 3 - n i t r o p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C([N+]([O-])=O)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 39% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001851 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 120 Benzyl (3-(4-Aminophenyl)-1-(diphenoxyphosphoryl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C(N)C=C4 Serine protease inhibitor library 13% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001852 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 121 B e n z y l ( ( 3 - A m i n o - 4 - ( d i m e t h y l a m i n o ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 22% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001853 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 122 Benzyl ((4-Acetamidophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(NC(C)=O)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 8% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001854 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 123 Benzyl ((4-(3,3-Dimethylureido)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(NC(N(C)C)=O)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 22% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001855 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 124 Benzyl ((Diphenoxyphosphoryl)(3-guanidinophenyl)methyl)-carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=CC(NC(N)=N)=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 15% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001856 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 125 Benzyl ((Diphenoxyphosphoryl)(5-guanidinonaphthalen-1-yl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=C5C=CC=C(NC(N)=N)C5=CC=C4.O=C(O)C(F)(F)F Serine protease inhibitor library 38% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001857 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 126 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-(methylsulfonamido)-phenyl)propyl)carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C(NS(=O)(C)=O)C=C4 Serine protease inhibitor library 10% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001858 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 127 Benzyl ((4-(Dimethylamino)-3-(methylsulfonamido)phenyl)-(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C(NS(=O)(C)=O)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library 46% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001859 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 128 Methyl ((Diphenoxyphosphoryl)(3-(trifluoromethyl)phenyl)-methyl)carbamate O=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=CC(C(F)(F)F)=C3 Serine protease inhibitor library 4% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001860 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 129 Benzyl (1-(Bis(4-acetamidophenoxy)phosphoryl)-2-(4-(trifluoromethyl)phenyl)ethyl)carbamate O=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library 1% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001861 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 130 Methyl (1-(Bis(4-acetamidophenoxy)phosphoryl)-2-(4-(trifluoromethyl)phenyl)ethyl)carbamate O=C(OC)NC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)CC3=CC=C(C(F)(F)F)C=C3 Serine protease inhibitor library 20% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001862 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 135 Methyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OC)NC(C1=CC=CC(N)=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library 7% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001863 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 136 Benzo[d][1,3]dioxol-5-ylmethyl ((3-Aminophenyl)-(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(C3=CC=CC(N)=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library 20% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001864 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 137 Benzyl ((3-Aminophenyl)(bis(4-acetamidophenoxy)phosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=C(NC(C)=O)C=C3)(OC4=CC=C(NC(C)=O)C=C4)=O Serine protease inhibitor library 21% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001865 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 138 Methyl ((3-Aminophenyl)(bis(4-acetamidophenoxy)phosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=CC(N)=C1)P(OC2=CC=C(NC(C)=O)C=C2)(OC3=CC=C(NC(C)=O)C=C3)=O Serine protease inhibitor library 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001866 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 145 Methyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=CC(C(N)=N)=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library 30% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001867 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 146 Benzyl ( ( B is(4-acetamidophenoxy)phosphoryl)( 3-carbamimidoylphenyl)methyl)carbamate O=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)C3=CC=CC(C(N)=N)=C3)NCC4=CC=CC=C4 Serine protease inhibitor library 29% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001868 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 147 Methyl ((Bis(4-acetamidophenoxy)phosphoryl)(3-carbamimidoylphenyl)methyl)carbamate O=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)C3=CC=CC(C(N)=N)=C3)NC Serine protease inhibitor library 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001869 30571121 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 151 (S)-Benzyl ((3-Aminophenyl)(cyano)methyl)carbamate O=C(OCC1=CC=CC=C1)N[C@@H](C2=CC=CC(N)=C2)C#N Serine protease inhibitor library 8% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB001870 30571121 Hsp100 NA Human NA NA Antiproliferative activity 16 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamate O=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001871 30571121 Hsp100 NA Human NA NA Antiproliferative activity 53 Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonate C[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001872 30571121 Hsp100 NA Human NA NA Antiproliferative activity 58 Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001873 30571121 Hsp100 NA Human NA NA Antiproliferative activity 66 Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001874 30571121 Hsp100 NA Human NA NA Antiproliferative activity 70 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001875 30571121 Hsp100 NA Human NA NA Antiproliferative activity 71 Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001876 30571121 Hsp100 NA Human NA NA Antiproliferative activity 78 Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001877 30571121 Hsp100 NA Human NA NA Antiproliferative activity 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001878 30571121 Hsp100 NA Human NA NA Antiproliferative activity 86 Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001879 30571121 Hsp100 NA Human NA NA Antiproliferative activity 89 Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 19.9 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001880 30571121 Hsp100 NA Human NA NA Antiproliferative activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 19.9 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001881 30571121 Hsp100 NA Human NA NA Antiproliferative activity 92 Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001882 30571121 Hsp100 NA Human NA NA Antiproliferative activity 107 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 8.6 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001883 30571121 Hsp100 NA Human NA NA Antiproliferative activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB001884 30571121 Hsp100 NA Human NA NA Antiproliferative activity 16 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamate O=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001885 30571121 Hsp100 NA Human NA NA Antiproliferative activity 53 Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonate C[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001886 30571121 Hsp100 NA Human NA NA Antiproliferative activity 58 Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001887 30571121 Hsp100 NA Human NA NA Antiproliferative activity 66 Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001888 30571121 Hsp100 NA Human NA NA Antiproliferative activity 70 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001889 30571121 Hsp100 NA Human NA NA Antiproliferative activity 71 Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001890 30571121 Hsp100 NA Human NA NA Antiproliferative activity 78 Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 28.4 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001891 30571121 Hsp100 NA Human NA NA Antiproliferative activity 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 23.8 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001892 30571121 Hsp100 NA Human NA NA Antiproliferative activity 86 Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001893 30571121 Hsp100 NA Human NA NA Antiproliferative activity 89 Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 10.5 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001894 30571121 Hsp100 NA Human NA NA Antiproliferative activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 28.3 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001895 30571121 Hsp100 NA Human NA NA Antiproliferative activity 92 Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001896 30571121 Hsp100 NA Human NA NA Antiproliferative activity 107 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 1.1 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001897 30571121 Hsp100 NA Human NA NA Antiproliferative activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA HepG2 Cancer HSPMDB001898 30571121 Hsp100 NA Human NA NA Antiproliferative activity 16 Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamate O=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001899 30571121 Hsp100 NA Human NA NA Antiproliferative activity 53 Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonate C[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001900 30571121 Hsp100 NA Human NA NA Antiproliferative activity 58 Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 57.8 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001901 30571121 Hsp100 NA Human NA NA Antiproliferative activity 66 Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamate O=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5 Serine protease inhibitor library NA NA NA NA 41.5 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001902 30571121 Hsp100 NA Human NA NA Antiproliferative activity 70 Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001903 30571121 Hsp100 NA Human NA NA Antiproliferative activity 71 Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001904 30571121 Hsp100 NA Human NA NA Antiproliferative activity 78 Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 65.6 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001905 30571121 Hsp100 NA Human NA NA Antiproliferative activity 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 27.5 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001906 30571121 Hsp100 NA Human NA NA Antiproliferative activity 86 Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4 Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001907 30571121 Hsp100 NA Human NA NA Antiproliferative activity 89 Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 5.9 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001908 30571121 Hsp100 NA Human NA NA Antiproliferative activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA 25.6 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001909 30571121 Hsp100 NA Human NA NA Antiproliferative activity 92 Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001910 30571121 Hsp100 NA Human NA NA Antiproliferative activity 107 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 0.4 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001911 30571121 Hsp100 NA Human NA NA Antiproliferative activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA 100 NA NA NA NA NA NA Luminescence based viability assay NA NA NA A549 Cancer HSPMDB001912 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 99.90% Bacterial growth inhibition assay (OD based) NA NA NA S. aureus (ATCC 29213) Bacterial infection HSPMDB001913 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 98.90% Bacterial growth inhibition assay (OD based) NA NA NA E. coli tolC deleted (JW5503) Bacterial infection HSPMDB001914 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 107 B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 69.90% Bacterial growth inhibition assay (OD based) NA NA NA E. coli tolC deleted (JW5503) Bacterial infection HSPMDB001915 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 115 Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetate O=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)F Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 99% Bacterial growth inhibition assay (OD based) NA NA NA E. coli tolC deleted (JW5503) Bacterial infection HSPMDB001916 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 98.50% Bacterial growth inhibition assay (OD based) NA NA NA E. coli (BW25113) + PAbetaN Bacterial infection HSPMDB001917 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 90 B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA 99.40% Bacterial growth inhibition assay (OD based) NA NA NA E. coli clpP deleted (JW0427-1) + PAbetaN Bacterial infection HSPMDB001918 30571121 Hsp100 NA Bacteria NA NA Antibacterial activity 85 Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamate O=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O Serine protease inhibitor library NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA NA E. coli (BW25113) + DPTA NONOate Bacterial infection HSPMDB001919 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID16472035/CID676352 2-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochloride Cl.C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001920 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-150/CID886813 2-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochloride Cl.C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001921 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD03665 (10E)-10-(hydroxymethylidene)-9,10-dihydrophenanthren-9-one O\C=C1\C(=O)C2=C(C=CC=C2)C2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001922 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-127/CID6763 phenanthrene-9,10-dione C1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001923 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD02342 1-(4-Methylphenyl)-3-phenyl-2-propyn-1-one CC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 47 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001924 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID934321 2-chloro-1-(1-methylindol-3-yl)ethanone CN1C=C(C2=CC=CC=C21)C(=O)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001925 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA S09756 9-[(E)-2-nitroethenyl]anthracene [O-][N+](=O)\C=C\C1=C2C=CC=CC2=CC2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.28 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001926 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD00597 3-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-one O1C(=NC2=C1C=CC=C2)SC2=CC(CC(C2)(C)C)=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001927 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SEW05182 5-({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione CC1(C)OC(=O)C(=CC2=CC=C(O2)C2=C(Cl)C=CC(=C2)C(F)(F)F)C(=O)O1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 10 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA Bacterial infection HSPMDB001928 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1109468 5-amino-4-cyano-N-[(2-methoxynaphthalen-1-yl)methylideneamino]-3-methylthiophene-2-carboxamide CC1=C(SC(=C1C#N)N)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.6 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001929 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-132/CID2939678 2-[1-hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acid C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CC(=C3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001930 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-130/CID9586497 2-[(E)-[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]guanidine C1=CC(=CC=C1C=NN=C(N)N)OCC2=C(C=C(C=C2)Cl)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 51 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001931 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-204/CID3500086 2-(5-chloro-1-ethyl-3-nitro-6-oxopyridazin-4-yl)-2-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetonitrile CCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=C(S2)C=CC(=C3)C(F)(F)F)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 52 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001932 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5413643 2-[4-methyl-6-(phenylamino)pyrimidin-2-yl]phenol CC1=CC(NC2=CC=CC=C2)=NC(=N1)C1=C(O)C=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 53 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001933 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-131/CID2867539/CID/9567210 3-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-6-phenyl-4H-1,2,4-triazin-5-one COC1=CC=C(C=C1)C=NNC2=NN=C(C(=O)N2)C3=CC=CC=C3 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 54 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001934 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-128/CID987585 N-(1-benzyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamide C1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NC(=O)C5=CC=CC=C5Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 55 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001935 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID6524677 (4Z)-4-[[2-(7-chloroquinolin-4-yl)hydrazinyl]methylidene]-2-hydroxycyclohexa-2,5-dien-1-one C1=CC2=C(C=CN=C2C=C1Cl)NNC=C3C=CC(=O)C(=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 36 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001936 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SPB01017 [1-(1,3-dithiolan-2-yl)naphthalen-2-yl] thiophene-2-carboxylate C1CSC(S1)C2=C(C=CC3=CC=CC=C32)OC(=O)C4=CC=CS4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001937 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA HTS01888 N-[4-(3-Chloro-4-methylphenyl)-5-methyl-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole-4-sulfonamide Cc1ccc(cc1Cl)c2nc(NS(=O)(=O)c3cccc4nonc34)sc2C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 14.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001938 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-129/CID801956 methyl 2-[(2-methylbenzoyl)carbamothioylamino]benzoate CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=CC=C2C(=O)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001939 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5756550 (5Z)-5-[(2-phenyl-1H-indol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C=C4C(=O)NC(=S)S4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001940 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD07581 6-[(2-chlorophenyl)amino]-2-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile ClC1=CC=CC=C1NC1=C(C#N)C(=O)NC(S1)C1=C(Cl)C=CC=C1Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 5.9 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001941 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD02660 methyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylate [H]COC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001942 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SP01086 3-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazole CSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 25 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001943 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID3598 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 5.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001944 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2884885 2,2-dichloro-N-(4-fluorophenyl)-3-phenylcyclopropane-1-carboxamide C1=CC=C(C=C1)C2C(C2(Cl)Cl)C(=O)NC3=CC=C(C=C3)F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001945 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID409928 2-[3-(dibutylamino)propyl]isoindole-1,3-dione CCCCN(CCCC)CCCN1C(=O)C2=CC=CC=C2C1=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001946 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5875182 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4SC)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 22 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001947 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID16194309 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-(2-methylpropylsulfonyl)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4S(=O)(=O)CC(C)C)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 12 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001948 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5691857 2-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-one COC1=CC=CC(=C1)N2C(=O)C3=CC=CC=C3N=C2SCC4=CC(=O)OC5=CC(=C(C=C45)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 21 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001949 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-1206/CID2384538 2-(chloromethyl)-1H-pyrimido[1,2-a]benzimidazol-4-one C1=CC=C2C(=C1)N=C3N2C(=O)C=C(N3)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001950 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-202/CID2810445 2,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide C1=CC=C2C(=C1)C(=O)C(C2=O)(NC(=O)C3=C(C=CC=C3Cl)Cl)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001951 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2175556 4-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]benzenesulfonamide C1=CC(=CC=C1NC2=NC(=CS2)C3=C(C=C(C=C3)O)O)S(=O)(=O)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 24 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001952 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-201/CID2810155 2-methyl-N-(7-methyl-4-oxothieno[3,2-d][1,3]thiazin-2-yl)benzamide CC1=CC=CC=C1C(=O)NC2=NC3=C(C(=O)S2)SC=C3C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001953 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-209/CID2472581 [2-(1H-indol-3-yl)-2-oxoethyl] 5-nitrothiophene-2-carboxylate C1=CC=C2C(=C1)C(=CN2)C(=O)COC(=O)C3=CC=C(S3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 51 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001954 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-199/CID4072379 N'-acridin-9-yl-2,4-dihydroxybenzohydrazide C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NNC(=O)C4=C(C=C(C=C4)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 52 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001955 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1625680 4-[5-[(Z)-2-carboxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethenyl]furan-2-yl]-2-chlorobenzoic acid CC1=NC(=NN1)SC(=CC2=CC=C(O2)C3=CC(=C(C=C3)C(=O)O)Cl)C(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 53 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001956 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KM08995 3-(5-acetylthiophen-2-yl)prop-2-ynyl N-phenylcarbamate CC(=O)C1=CC=C(S1)C#CCOC(=O)NC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 7.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001957 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1976446 (6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-2-pyridin-4-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one C1=CC=C2C(=C1)C(=O)C(=CO2)C=C3C(=N)N4C(=NC3=O)SC(=N4)C5=CC=NC=C5 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 11 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001958 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID930238 7-propan-2-yl-10-thia-8,13,15-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1,6,8,11(16),13-pentaene-12-thione CC(C)C1=C2CCCC2=C3C4=C(C(=S)N=CN4)SC3=N1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 42 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001959 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2978460 4-[[4-(2-fluorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]sulfonylamino]benzoic acid C1C=CC2C1C(NC3=C2C=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 19 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001960 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD00823 3-(1H-indol-3-ylmethylidene)indolin-2-one O=c1nc2ccccc2c1=Cc1cnc2ccccc21 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001961 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD01560 4-pyren-1-ylbutanoic acid C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCCC(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 10 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001962 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-133/CID5559718 (Z)-2-(1,3-benzothiazol-2-yl)-3-hydroxy-4-(4-methylphenyl)sulfanylbut-2-enenitrile CC1=CC=C(C=C1)SCC(=C(C#N)C2=NC3=CC=CC=C3S2)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001963 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-205/CID5982653 3-nitro-4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinyl]benzenesulfonamide C1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])NN=CC2=C(C(=C(C=C2)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001964 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-232/CID3787408 N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-4-methylbenzenesulfonamide CCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)S(=O)(=O)C4=CC=CC=C4)NS(=O)(=O)C5=CC=C(C=C5)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001965 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-233/CID2044030 N-(1-benzylpyrrolo[3,2-b]quinoxalin-2-yl)-4-chlorobenzenesulfonamide C1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=C(C=C5)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001966 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD02506 3-{bicyclo[2.2.1]hept-5-en-2-yl}-1-{[(4-bromo-3-chlorophenyl)carbamothioyl]amino}thiourea ClC1=CC(NC(=S)NNC(=S)NC2CC3CC2C=C3)=CC=C1Br Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001967 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD06082 N-{[(2,5-dichlorophenyl)carbamothioyl]amino}-2-{[(E)-[(2,4-dichlorophenyl)methylidene]amino]oxy}acetamide ClC1=CC(Cl)=C(\C=N\OCC(=O)NNC(=S)NC2=C(Cl)C=CC(Cl)=C2)C=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001968 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID160115 5,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-one CC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 44 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001969 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID16472035/CID676352 2-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochloride C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4.Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001970 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-150/CID886813 N-benzyl-2-(2-fluorophenyl)quinazolin-4-amine Fc1ccccc1c2nc(NCc3ccccc3)c4ccccc4n2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001971 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD03665 (10E)-10-(hydroxymethylidene)-9,10-dihydrophenanthren-9-one O\C=C1\C(=O)C2=C(C=CC=C2)C2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.26 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001972 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-127/CID6763 phenanthrene-9,10-dione C1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.5 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001973 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD02342 1-(4-Methylphenyl)-3-phenyl-2-propyn-1-one CC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001974 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID934321 2-chloro-1-(1-methylindol-3-yl)ethanone CN1C=C(C2=CC=CC=C21)C(=O)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.3 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001975 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA S09756 9-[(E)-2-nitroethenyl]anthracene [O-][N+](=O)\C=C\C1=C2C=CC=CC2=CC2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.8 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001976 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD00597 3-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-one O1C(=NC2=C1C=CC=C2)SC2=CC(CC(C2)(C)C)=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 6.1 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001977 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SEW05182 5-({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione CC1(C)OC(=O)C(=CC2=CC=C(O2)C2=C(Cl)C=CC(=C2)C(F)(F)F)C(=O)O1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 13 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001978 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1109468 5-amino-4-cyano-N-[(2-methoxynaphthalen-1-yl)methylideneamino]-3-methylthiophene-2-carboxamide CC1=C(SC(=C1C#N)N)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001979 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-132/CID2939678 2-[1-hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acid C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CC(=C3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 24 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001980 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-130/CID9586497 2-[(E)-[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]guanidine C1=CC(=CC=C1C=NN=C(N)N)OCC2=C(C=C(C=C2)Cl)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 24 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001981 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-204/CID3500086 2-(5-chloro-1-ethyl-3-nitro-6-oxopyridazin-4-yl)-2-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetonitrile CCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=C(S2)C=CC(=C3)C(F)(F)F)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 14 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001982 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5413643 2-[4-methyl-6-(phenylamino)pyrimidin-2-yl]phenol CC1=CC(NC2=CC=CC=C2)=NC(=N1)C1=C(O)C=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 10 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001983 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-131/CID2867539/CID/9567210 3-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-6-phenyl-4H-1,2,4-triazin-5-one COC1=CC=C(C=C1)C=NNC2=NN=C(C(=O)N2)C3=CC=CC=C3 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001984 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-128/CID987585 N-(1-benzyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamide C1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NC(=O)C5=CC=CC=C5Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 147 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001985 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID6524677 (4Z)-4-[[2-(7-chloroquinolin-4-yl)hydrazinyl]methylidene]-2-hydroxycyclohexa-2,5-dien-1-one C1=CC2=C(C=CN=C2C=C1Cl)NNC=C3C=CC(=O)C(=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 4.9 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001986 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SPB01017 [1-(1,3-dithiolan-2-yl)naphthalen-2-yl] thiophene-2-carboxylate C1CSC(S1)C2=C(C=CC3=CC=CC=C32)OC(=O)C4=CC=CS4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 6.4 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001987 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA HTS01888 N-[4-(3-Chloro-4-methylphenyl)-5-methyl-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole-4-sulfonamide Cc1ccc(cc1Cl)c2nc(NS(=O)(=O)c3cccc4nonc34)sc2C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 19 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001988 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-129/CID801956 methyl 2-[(2-methylbenzoyl)carbamothioylamino]benzoate CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=CC=C2C(=O)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.1 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001989 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5756550 (5Z)-5-[(2-phenyl-1H-indol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C=C4C(=O)NC(=S)S4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 34 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001990 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD07581 6-[(2-chlorophenyl)amino]-2-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile ClC1=CC=CC=C1NC1=C(C#N)C(=O)NC(S1)C1=C(Cl)C=CC=C1Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 4 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001991 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD02660 ethyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylate CCOC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001992 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA SP01086 3-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazole CSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >50 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001993 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID3598 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.7 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001994 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2884885 2,2-dichloro-N-(4-fluorophenyl)-3-phenylcyclopropane-1-carboxamide C1=CC=C(C=C1)C2C(C2(Cl)Cl)C(=O)NC3=CC=C(C=C3)F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.15 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001995 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID409928 2-[3-(dibutylamino)propyl]isoindole-1,3-dione CCCCN(CCCC)CCCN1C(=O)C2=CC=CC=C2C1=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.6 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001996 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5875182 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4SC)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 8.3 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001997 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID16194309 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-(2-methylpropylsulfonyl)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4S(=O)(=O)CC(C)C)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 7.8 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001998 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID5691857 2-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-one COC1=CC=CC(=C1)N2C(=O)C3=CC=CC=C3N=C2SCC4=CC(=O)OC5=CC(=C(C=C45)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 4.1 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB001999 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-1206/CID2384538 2-(chloromethyl)-1H-pyrimido[1,2-a]benzimidazol-4-one C1=CC=C2C(=C1)N=C3N2C(=O)C=C(N3)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.9 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002000 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-202/CID2810445 2,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide C1=CC=C2C(=C1)C(=O)C(C2=O)(NC(=O)C3=C(C=CC=C3Cl)Cl)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002001 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2175556 4-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]benzenesulfonamide C1=CC(=CC=C1NC2=NC(=CS2)C3=C(C=C(C=C3)O)O)S(=O)(=O)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.7 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002002 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-201/CID2810155 2-methyl-N-(7-methyl-4-oxothieno[3,2-d][1,3]thiazin-2-yl)benzamide CC1=CC=CC=C1C(=O)NC2=NC3=C(C(=O)S2)SC=C3C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 104 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002003 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-209/CID2472581 [2-(1H-indol-3-yl)-2-oxoethyl] 5-nitrothiophene-2-carboxylate C1=CC=C2C(=C1)C(=CN2)C(=O)COC(=O)C3=CC=C(S3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 92 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002004 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-199/CID4072379 N'-acridin-9-yl-2,4-dihydroxybenzohydrazide C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NNC(=O)C4=C(C=C(C=C4)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 18 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002005 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1625680 4-[5-[(Z)-2-carboxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethenyl]furan-2-yl]-2-chlorobenzoic acid CC1=NC(=NN1)SC(=CC2=CC=C(O2)C3=CC(=C(C=C3)C(=O)O)Cl)C(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 0.85 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002006 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KM08995 3-(5-acetylthiophen-2-yl)prop-2-ynyl N-phenylcarbamate CC(=O)C1=CC=C(S1)C#CCOC(=O)NC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.4 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002007 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID1976446 (6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-2-pyridin-4-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one C1=CC=C2C(=C1)C(=O)C(=CO2)C=C3C(=N)N4C(=NC3=O)SC(=N4)C5=CC=NC=C5 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.6 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002008 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID930238 7-propan-2-yl-10-thia-8,13,15-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1,6,8,11(16),13-pentaene-12-thione CC(C)C1=C2CCCC2=C3C4=C(C(=S)N=CN4)SC3=N1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 5.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002009 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID2978460 4-[[4-(2-fluorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]sulfonylamino]benzoic acid C1C=CC2C1C(NC3=C2C=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 9 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002010 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD00823 3-(1H-indol-3-ylmethylidene)indolin-2-one O=c1nc2ccccc2c1=Cc1cnc2ccccc21 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 9.2 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002011 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA JFD01560 4-pyren-1-ylbutanoic acid C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCCC(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 12 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002012 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-133/CID5559718 (Z)-2-(1,3-benzothiazol-2-yl)-3-hydroxy-4-(4-methylphenyl)sulfanylbut-2-enenitrile CC1=CC=C(C=C1)SCC(=C(C#N)C2=NC3=CC=CC=C3S2)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 8.8 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002013 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-205/CID5982653 3-nitro-4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinyl]benzenesulfonamide C1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])NN=CC2=C(C(=C(C=C2)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002014 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-232/CID3787408 N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-4-methylbenzenesulfonamide CCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)S(=O)(=O)C4=CC=CC=C4)NS(=O)(=O)C5=CC=C(C=C5)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002015 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-1-233/CID2044030 N-(1-benzylpyrrolo[3,2-b]quinoxalin-2-yl)-4-chlorobenzenesulfonamide C1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=C(C=C5)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 80 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002016 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD02506 3-{bicyclo[2.2.1]hept-5-en-2-yl}-1-{[(4-bromo-3-chlorophenyl)carbamothioyl]amino}thiourea ClC1=CC(NC(=S)NNC(=S)NC2CC3CC2C=C3)=CC=C1Br Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002017 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CD06082 N-{[(2,5-dichlorophenyl)carbamothioyl]amino}-2-{[(E)-[(2,4-dichlorophenyl)methylidene]amino]oxy}acetamide ClC1=CC(Cl)=C(\C=N\OCC(=O)NNC(=S)NC2=C(Cl)C=CC(Cl)=C2)C=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 20 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002018 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA CID160115 5,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-one CC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002019 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA Eeyarestatin I (Eerl) 2-[3-(4-chlorophenyl)-4-[(4-chlorophenyl)carbamoyl-hydroxyamino]-5,5-dimethyl-2-oxoimidazolidin-1-yl]-N-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]acetamide CC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002020 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA Myriad 19/KSC-1-275 4-[(4-phenyl-1,3-thiazol-2-yl)amino]phenol C1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=C(C=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 21 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002021 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA Myriad 12/KSC-1-277 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 20 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002022 21383145 Hsp100 p97 Human Cytosol Inhibition of ATPase activity NA KSC-16-5 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]imino]cyclohexa-2,5-dien-1-one C1=CC(=O)C=CC1=NC2=NC(=CS2)C3=CC=C(C=C3)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 68 NA NA NA NA Nucleotide binding domain ATPase assay NA NA NA NA NA NA NA HSPMDB002023 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID16472035/CID676352 2-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochloride C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4.Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 2.6 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002024 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-150/CID886813 N-benzyl-2-(2-fluorophenyl)quinazolin-4-amine Fc1ccccc1c2nc(NCc3ccccc3)c4ccccc4n2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 9 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002025 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity JFD03665 (10E)-10-(hydroxymethylidene)-9,10-dihydrophenanthren-9-one O\C=C1\C(=O)C2=C(C=CC=C2)C2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.1 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002026 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-127/CID6763 phenanthrene-9,10-dione C1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 1.3 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002027 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity JFD02342 1-(4-Methylphenyl)-3-phenyl-2-propyn-1-one CC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.4 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002028 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID934321 2-chloro-1-(1-methylindol-3-yl)ethanone CN1C=C(C2=CC=CC=C21)C(=O)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.6 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002029 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity S09756 9-[(E)-2-nitroethenyl]anthracene [O-][N+](=O)\C=C\C1=C2C=CC=CC2=CC2=C1C=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 5 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002030 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity JFD00597 3-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-one O1C(=NC2=C1C=CC=C2)SC2=CC(CC(C2)(C)C)=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 6.6 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002031 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity SEW05182 5-({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione CC1(C)OC(=O)C(=CC2=CC=C(O2)C2=C(Cl)C=CC(=C2)C(F)(F)F)C(=O)O1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 7.5 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002032 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID1109468 5-amino-4-cyano-N-[(2-methoxynaphthalen-1-yl)methylideneamino]-3-methylthiophene-2-carboxamide CC1=C(SC(=C1C#N)N)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 10 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002033 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-132/CID2939678 2-[1-hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acid C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CC(=C3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 8.4 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002034 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-130/CID9586497 2-[(E)-[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]guanidine C1=CC(=CC=C1C=NN=C(N)N)OCC2=C(C=C(C=C2)Cl)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 11 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002035 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-204/cid3500086 2-(5-chloro-1-ethyl-3-nitro-6-oxopyridazin-4-yl)-2-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetonitrile CCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=C(S2)C=CC(=C3)C(F)(F)F)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 13 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002036 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID5413643 2-[4-methyl-6-(phenylamino)pyrimidin-2-yl]phenol CC1=CC(NC2=CC=CC=C2)=NC(=N1)C1=C(O)C=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 16 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002037 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-131/CID2867539/CID/9567210 3-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-6-phenyl-4H-1,2,4-triazin-5-one COC1=CC=C(C=C1)C=NNC2=NN=C(C(=O)N2)C3=CC=CC=C3 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 16 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002038 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-128/CID987585 N-(1-benzyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamide C1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NC(=O)C5=CC=CC=C5Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 17 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002039 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID6524677 (4Z)-4-[[2-(7-chloroquinolin-4-yl)hydrazinyl]methylidene]-2-hydroxycyclohexa-2,5-dien-1-one C1=CC2=C(C=CN=C2C=C1Cl)NNC=C3C=CC(=O)C(=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 15 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002040 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity SPB01017 [1-(1,3-dithiolan-2-yl)naphthalen-2-yl] thiophene-2-carboxylate C1CSC(S1)C2=C(C=CC3=CC=CC=C32)OC(=O)C4=CC=CS4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 19 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002041 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity HTS01888 N-[4-(3-Chloro-4-methylphenyl)-5-methyl-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole-4-sulfonamide Cc1ccc(cc1Cl)c2nc(NS(=O)(=O)c3cccc4nonc34)sc2C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 19 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002042 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-129/CID801956 methyl 2-[(2-methylbenzoyl)carbamothioylamino]benzoate CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=CC=C2C(=O)OC Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 21 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002043 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID5756550 (5Z)-5-[(2-phenyl-1H-indol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C=C4C(=O)NC(=S)S4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 22 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002044 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD07581 6-[(2-chlorophenyl)amino]-2-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile ClC1=CC=CC=C1NC1=C(C#N)C(=O)NC(S1)C1=C(Cl)C=CC=C1Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 23 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002045 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD02660 ethyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylate CCOC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 23 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002046 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity SP01086 3-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazole CSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 23 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002047 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID3598 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 27 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002048 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID2884885 2,2-dichloro-N-(4-fluorophenyl)-3-phenylcyclopropane-1-carboxamide C1=CC=C(C=C1)C2C(C2(Cl)Cl)C(=O)NC3=CC=C(C=C3)F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 27 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002049 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID409928 2-[3-(dibutylamino)propyl]isoindole-1,3-dione CCCCN(CCCC)CCCN1C(=O)C2=CC=CC=C2C1=O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 36 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002050 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID5875182 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4SC)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 31 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002051 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID16194309 5-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-(2-methylpropylsulfonyl)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one CC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4S(=O)(=O)CC(C)C)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002052 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID5691857 2-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-one COC1=CC=CC(=C1)N2C(=O)C3=CC=CC=C3N=C2SCC4=CC(=O)OC5=CC(=C(C=C45)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 39 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002053 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-1206/CID2384538 2-(chloromethyl)-1H-pyrimido[1,2-a]benzimidazol-4-one C1=CC=C2C(=C1)N=C3N2C(=O)C=C(N3)CCl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 38 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002054 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-202/CID2810445 2,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide C1=CC=C2C(=C1)C(=O)C(C2=O)(NC(=O)C3=C(C=CC=C3Cl)Cl)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 42 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002055 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID2175556 4-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]benzenesulfonamide C1=CC(=CC=C1NC2=NC(=CS2)C3=C(C=C(C=C3)O)O)S(=O)(=O)N Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 60 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002056 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-201/CID2810155 2-methyl-N-(7-methyl-4-oxothieno[3,2-d][1,3]thiazin-2-yl)benzamide CC1=CC=CC=C1C(=O)NC2=NC3=C(C(=O)S2)SC=C3C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 62 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002057 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-209/CID2472581 [2-(1H-indol-3-yl)-2-oxoethyl] 5-nitrothiophene-2-carboxylate C1=CC=C2C(=C1)C(=CN2)C(=O)COC(=O)C3=CC=C(S3)[N+](=O)[O-] Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 66 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002058 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-199/CID4072379 N'-acridin-9-yl-2,4-dihydroxybenzohydrazide C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NNC(=O)C4=C(C=C(C=C4)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 68 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002059 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID1625680 4-[5-[(Z)-2-carboxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethenyl]furan-2-yl]-2-chlorobenzoic acid CC1=NC(=NN1)SC(=CC2=CC=C(O2)C3=CC(=C(C=C3)C(=O)O)Cl)C(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002060 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KM08995 3-(5-acetylthiophen-2-yl)prop-2-ynyl N-phenylcarbamate CC(=O)C1=CC=C(S1)C#CCOC(=O)NC2=CC=CC=C2 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002061 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID1976446 (6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-2-pyridin-4-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one C1=CC=C2C(=C1)C(=O)C(=CO2)C=C3C(=N)N4C(=NC3=O)SC(=N4)C5=CC=NC=C5 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002062 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID930238 7-propan-2-yl-10-thia-8,13,15-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1,6,8,11(16),13-pentaene-12-thione CC(C)C1=C2CCCC2=C3C4=C(C(=S)N=CN4)SC3=N1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002063 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID2978460 4-[[4-(2-fluorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]sulfonylamino]benzoic acid C1C=CC2C1C(NC3=C2C=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5F Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002064 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD00823 3-(1H-indol-3-ylmethylidene)indolin-2-one O=c1nc2ccccc2c1=Cc1cnc2ccccc21 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002065 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity JFD01560 4-pyren-1-ylbutanoic acid C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCCC(=O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002066 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-133/CID5559718 (Z)-2-(1,3-benzothiazol-2-yl)-3-hydroxy-4-(4-methylphenyl)sulfanylbut-2-enenitrile CC1=CC=C(C=C1)SCC(=C(C#N)C2=NC3=CC=CC=C3S2)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002067 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-205/CID5982653 3-nitro-4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinyl]benzenesulfonamide C1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])NN=CC2=C(C(=C(C=C2)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002068 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-232/CID3787408 N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-4-methylbenzenesulfonamide CCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)S(=O)(=O)C4=CC=CC=C4)NS(=O)(=O)C5=CC=C(C=C5)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002069 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-1-233/CID2044030 N-(1-benzylpyrrolo[3,2-b]quinoxalin-2-yl)-4-chlorobenzenesulfonamide C1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=C(C=C5)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002070 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD02506 ethyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylate CCOC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002071 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CD06082 3-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazole CSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002072 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity CID160115 5,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-one CC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA >30 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002073 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity Eeyarestatin I (Eerl) 2-[3-(4-chlorophenyl)-4-[(4-chlorophenyl)carbamoyl-hydroxyamino]-5,5-dimethyl-2-oxoimidazolidin-1-yl]-N-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]acetamide CC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)C Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 3.7 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002074 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity Myriad 19/KSC-1-275 4-[(4-phenyl-1,3-thiazol-2-yl)amino]phenol C1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=C(C=C3)O Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 26 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002075 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity Myriad 12/KSC-1-277 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 16 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002076 21383145 Hsp100 p97 Human Cytosol NA Substrate degradation activity KSC-16-5 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]imino]cyclohexa-2,5-dien-1-one C1=CC(=O)C=CC1=NC2=NC(=CS2)C3=CC=C(C=C3)Cl Maybridge, Hitfinder, and NIH molecular libraries NA NA NA 38 NA NA NA NA Nucleotide binding domain NA NA Reporter degradation assay (UbG76V-GFP) NA NA NA HeLa Cancer HSPMDB002077 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity Mg132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 0.4 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA MRC-5 NA HSPMDB002078 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity Mg132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 0.2 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA HEK293 NA HSPMDB002079 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity Mg132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 1.5 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002080 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity Mg132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 0.14 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA RPMI8226 NA HSPMDB002081 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity DBeQ N2 , N4 -dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 6.6 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA MRC-5 NA HSPMDB002082 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity DBeQ N2 , N4 -dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 4 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA HEK293 NA HSPMDB002083 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity DBeQ N2 , N4 -dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 3.1 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002084 21383145 Hsp100 p97 Human Cytosol NA Antiproliferative activity DBeQ N2 , N4 -dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Maybridge, Hitfinder, and NIH molecular libraries NA NA NA NA NA NA NA 1.2 Nucleotide binding domain NA 50% Luminescence based viability assay NA NA NA RPMI8226 NA HSPMDB002085 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor NA NA NA 6.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002086 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002087 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002088 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002089 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002090 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor NA NA NA 6.6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002091 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA Palmostatin M (3S,4S)-3-decyl-4-[4-[3-(dimethylamino)propylsulfonyl]butyl]oxetan-2-one CCCCCCCCCCC1C(OC1=O)CCCCS(=O)(=O)CCCN(C)C Non beta lactone inhibitor NA NA NA 21 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002092 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002093 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002094 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002095 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 75% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002096 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 70% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002097 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002098 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002099 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002100 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002101 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 45% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002102 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 85% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002103 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 40% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002104 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002105 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002106 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002107 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 80% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002108 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 40% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002109 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002110 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 30% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002111 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002112 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002113 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 25% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002114 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 25% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002115 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002116 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002117 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002118 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002119 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 60% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002120 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002121 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002122 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 98% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002123 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002124 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 98% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002125 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002126 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002127 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 45% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002128 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002129 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002130 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002131 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002132 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002133 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002134 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 80% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002135 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002136 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002137 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 75% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002138 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002139 26083639 Hsp100 ClpP2 Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002140 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002141 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002142 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002143 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 99% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002144 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 88% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002145 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 99% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002146 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002147 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002148 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002149 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 88% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002150 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002151 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002152 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 80% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002153 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002154 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002155 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 88% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002156 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 65% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002157 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 25% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002158 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 60% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002159 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 40% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002160 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 45% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002161 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 80% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002162 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002163 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002164 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002165 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 25% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002166 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002167 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002168 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002169 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002170 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 40% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002171 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 45% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002172 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002173 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002174 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002175 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 10-15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002176 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002177 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002178 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 50% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002179 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002180 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002181 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002182 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 5-10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002183 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 50% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002184 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002185 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002186 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002187 26083639 Hsp100 ClpP Human Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002188 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002189 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002190 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 75% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002191 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 25% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002192 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002193 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002194 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 70% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002195 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002196 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 80% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002197 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 65% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002198 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002199 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002200 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002201 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002202 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002203 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 25% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002204 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV126 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002205 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV127 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002206 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV166 (2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-one COC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1 Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002207 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV167 4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate O=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002208 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV168 4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate CN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1 Non beta lactone inhibitor 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002209 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV170 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OC Non beta lactone inhibitor 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002210 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Non beta lactone inhibitor 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002211 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Non beta lactone inhibitor 15% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002212 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML16 Methyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoate C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Non beta lactone inhibitor (AV170 derivative) 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002213 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML21 Methyl 4-(2-(3,4,5-trimethoxyphenyl)acetoxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002214 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML33 Methyl 4-((3-(1H-indol-3-yl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002215 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML03 Isopropyl 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2c[nH]c3ccccc23)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002216 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML23 methyl 3-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoate COc1cc(CCC(=O)Oc2ccc(cc2)C(=O)OC(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002217 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH18 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COC(=O)c1cccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c1 Non beta lactone inhibitor (AV170 derivative) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002218 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML14 Butyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3noc(C)n3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002219 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML27 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate CCCCOC(=O)CCc1cc(OC)c(OC)c(OC)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002220 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH19 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002221 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML25 4-formylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3oc(C)nn3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002222 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML05 4-Methoxyphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(C=O)cc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002223 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML06 Phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002224 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML28 4-(Dimethylamino)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 60% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002225 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML92 Methyl 4-((3-(3,4-dimethoxyphenyl)propanoyl)oxy)benzoate COc1cc(CCC(=O)Oc2ccc(cc2)N(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002226 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML57 Methyl 4-((3-(3-acetylphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2ccc(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 55% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002227 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML09 Cyclohexyl 3-(3,4,5-trimethoxyphenyl)propanoate COC(=O)c1ccc(OC(=O)CCc2cccc(c2)C(C)=O)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002228 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML18 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoic acid COc1cc(CCC(=O)OC2CCCCC2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002229 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML20 Methyl 4-(((3,4,5-trimethoxybenzyl)carbamoyl)oxy)benzoate COc1cc(CCC(=O)Oc2ccc(cc2)C(O)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 30% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002230 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML68 methyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoate COC(=O)C1=CC=C(OC(=O)CCC2=CC=CS2)C=C1 Non beta lactone inhibitor (AV170 derivative) 5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002231 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV134 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-sulfonamide CC(C)(C)C(=O)N1CCC(CC1)S(=O)(=O)NC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002232 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML31 Methyl 4-(hept-6-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 15% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002233 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML24 2-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 55% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002234 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML30 Methyl 4-(undec-10-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCCCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002235 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML74 4-(Methoxycarbonyl)phenyl 3,4,5-trimethoxybenzoate COC(=O)c1ccc(OC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 75% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002236 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML12 4-Nitrophenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002237 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV137 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamide CC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002238 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML16 Methyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002239 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML21 Methyl 4-(2-(3,4,5-trimethoxyphenyl)acetoxy)benzoate COC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002240 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML33 Methyl 4-((3-(1H-indol-3-yl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2c[nH]c3ccccc23)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002241 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML03 Isopropyl 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COc1cc(CCC(=O)Oc2ccc(cc2)C(=O)OC(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 90-95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002242 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML23 methyl 3-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoate COC(=O)c1cccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c1 Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002243 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH18 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3noc(C)n3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002244 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML14 Butyl 3-(3,4,5-trimethoxyphenyl)propanoate CCCCOC(=O)CCc1cc(OC)c(OC)c(OC)c1 Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002245 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML27 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 92% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002246 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH19 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3oc(C)nn3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002247 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML25 4-formylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(C=O)cc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 80% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002248 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML05 4-Methoxyphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002249 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML06 Phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002250 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML28 4-(Dimethylamino)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)N(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002251 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML92 Methyl 4-((3-(3,4-dimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2ccc(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002252 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML57 Methyl 4-((3-(3-acetylphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cccc(c2)C(C)=O)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002253 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML09 Cyclohexyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)OC2CCCCC2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002254 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML18 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoic acid COc1cc(CCC(=O)Oc2ccc(cc2)C(O)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002255 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML20 Methyl 4-(((3,4,5-trimethoxybenzyl)carbamoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)NCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002256 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML68 methyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoate COC(=O)c1ccc(OC(=O)CCc2sccc2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002257 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV134 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-sulfonamide CC(C)(C)C(=O)N1CCC(CC1)[S](=O)(=O)Nc2ccc(cc2)N3CCCC3=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002258 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML31 Methyl 4-(hept-6-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002259 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML24 2-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 8% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002260 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML30 Methyl 4-(undec-10-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCCCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002261 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML74 4-(Methoxycarbonyl)phenyl 3,4,5-trimethoxybenzoate COC(=O)c1ccc(OC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002262 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML12 4-Nitrophenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 15% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002263 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV137 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamide CC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002264 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML16 Methyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002265 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML21 Methyl 4-(2-(3,4,5-trimethoxyphenyl)acetoxy)benzoate COC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 75% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002266 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML33 Methyl 4-((3-(1H-indol-3-yl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2c[nH]c3ccccc23)cc1 Non beta lactone inhibitor (AV170 derivative) 70% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002267 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML03 Isopropyl 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COc1cc(CCC(=O)Oc2ccc(cc2)C(=O)OC(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 60% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002268 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML23 methyl 3-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoate COC(=O)c1cccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c1 Non beta lactone inhibitor (AV170 derivative) 55% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002269 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH18 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3noc(C)n3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 50% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002270 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML14 Butyl 3-(3,4,5-trimethoxyphenyl)propanoate CCCCOC(=O)CCc1cc(OC)c(OC)c(OC)c1 Non beta lactone inhibitor (AV170 derivative) 50% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002271 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML27 4-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 45% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002272 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA MLIH19 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)c3oc(C)nn3)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 35% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002273 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML25 4-formylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(C=O)cc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 30% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002274 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML05 4-Methoxyphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 15% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002275 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML06 Phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002276 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML28 4-(Dimethylamino)phenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)N(C)C)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002277 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML92 Methyl 4-((3-(3,4-dimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2ccc(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002278 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML57 Methyl 4-((3-(3-acetylphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cccc(c2)C(C)=O)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002279 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML09 Cyclohexyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)OC2CCCCC2)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002280 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML18 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoic acid COc1cc(CCC(=O)Oc2ccc(cc2)C(O)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002281 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML20 Methyl 4-(((3,4,5-trimethoxybenzyl)carbamoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)NCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002282 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML68 methyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoate COC(=O)C1=CC=C(OC(=O)CCC2=CC=CS2)C=C1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002283 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV134 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-sulfonamide CC(C)(C)C(=O)N1CCC(CC1)S(=O)(=O)NC1=CC=C(C=C1)N1CCCC1=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002284 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML31 Methyl 4-(hept-6-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002285 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML24 2-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccccc2C(C)=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002286 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML30 Methyl 4-(undec-10-ynoyloxy)benzoate COC(=O)c1ccc(OC(=O)CCCCCCCCC#C)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002287 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML74 4-(Methoxycarbonyl)phenyl 3,4,5-trimethoxybenzoate COC(=O)c1ccc(OC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002288 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML12 4-Nitrophenyl 3-(3,4,5-trimethoxyphenyl)propanoate COc1cc(CCC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002289 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV137 1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamide CC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=O Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002290 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML73 Methyl 4-((2-(3,4,5-trimethoxybenzyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(=C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002291 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML91 Methyl (E)-4-((3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002292 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML43 Methyl 4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 100% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002293 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML38 Methyl (E)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(/C)=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002294 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML37 Methyl 3-methyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002295 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML15 Methyl 3,5-dimethyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1cc(C)c(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002296 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML89 Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002297 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML90 Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002298 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML95 Methyl (R)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 55% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002299 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML96 Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 10% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002300 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML73 Methyl 4-((2-(3,4,5-trimethoxybenzyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(=C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002301 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML91 Methyl (E)-4-((3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002302 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML43 Methyl 4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002303 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML38 Methyl (E)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(/C)=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 70% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002304 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML37 Methyl 3-methyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002305 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML15 Methyl 3,5-dimethyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1cc(C)c(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002306 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML89 Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002307 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML90 Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 60% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002308 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML95 Methyl (R)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 10% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002309 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML96 Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002310 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML73 Methyl 4-((2-(3,4,5-trimethoxybenzyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(=C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 60% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002311 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML91 Methyl (E)-4-((3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002312 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML43 Methyl 4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 15% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002313 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML38 Methyl (E)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoate COC(=O)c1ccc(OC(=O)C(/C)=C/c2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 10% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002314 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML37 Methyl 3,5-dimethyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1cc(C)c(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002315 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML15 Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002316 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML89 Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) 20% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002317 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML90 Methyl (R)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 15% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002318 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML95 Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002319 26083639 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA ML96 Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoate CC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OC Non beta lactone inhibitor (AV170 derivative) 0-5% at 1 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002320 26083639 Hsp100 NA Human NA NA Antiproliferative activity AV170 methyl 4-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoate COC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) NA NA NA NA NA NA NA NA NA NA 10 MTT viability assay NA NA NA A549 Cancer HSPMDB002321 26083639 Hsp100 NA Human NA NA Antiproliferative activity ML21 methyl 4-{[2-(3,4,5-trimethoxyphenyl)acetyl]oxy}benzoate COC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) NA NA NA NA NA NA NA NA NA NA 10 MTT viability assay NA NA NA A549 Cancer HSPMDB002322 26083639 Hsp100 NA Human NA NA Antiproliferative activity ML89 Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) NA NA NA NA NA NA NA NA NA NA 10 MTT viability assay NA NA NA A549 Cancer HSPMDB002323 26083639 Hsp100 NA Human NA NA Antiproliferative activity ML90 Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoate COC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1 Non beta lactone inhibitor (AV170 derivative) NA NA NA NA NA NA NA NA NA NA 5-Oct MTT viability assay NA NA NA A549 Cancer HSPMDB002324 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV145 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Isopropyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamide CC(C)n1ncc2cc(cnc12)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 10 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002325 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV280 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3,4-dimethylbenzyl)-1H-pyrazolo[3,4-b]pyridine5-carboxamide (AV280) Cc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1C COMAS Library NA NA NA 1.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002326 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV191 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Benzyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamide O=C(NCc1coc(n1)c2sccc2)c3cnc4n(Cc5ccccc5)ncc4c3 COMAS Library NA NA NA 2 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002327 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV267 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide COc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1 COMAS Library NA NA NA 2.2 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002328 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV261 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(2-Phenethyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide CCc1ccccc1n2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5 COMAS Library NA NA NA 2.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002329 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV253 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide Cc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1 COMAS Library NA NA NA 2.4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002330 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV259 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Phenylpropyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide O=C(NCc1coc(n1)c2sccc2)c3cnc4n(CCCc5ccccc5)ncc4c3 COMAS Library NA NA NA 3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002331 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV268 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide Cc1cccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)c1 COMAS Library NA NA NA 3.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002332 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV264 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Cyanobenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide O=C(NCc1coc(n1)c2sccc2)c3cnc4n(Cc5cccc(c5)C#N)ncc4c3 COMAS Library NA NA NA 4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002333 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV266 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide COc1cccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)c1 COMAS Library NA NA NA 4.4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002334 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV265 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Cyanobenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide O=C(NCc1coc(n1)c2sccc2)c3cnc4n(Cc5ccc(cc5)C#N)ncc4c3 COMAS Library NA NA NA 5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002335 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV279 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Isopropylbenzyl)-1H-pyrazolo[3,4-b]pyridine5-carboxamide CC(C)c1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1 COMAS Library NA NA NA 5.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002336 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV145 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Isopropyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamide CC(C)n1ncc2cc(cnc12)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 10 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002337 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV286 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzylaminocarbonylamino)benzamide O=C(NCc1ccccc1)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 0.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002338 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV241 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(tert-butyloxycarbonylamino)benzamide CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3 COMAS Library NA NA NA 1.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002339 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV285 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzyloxycarbonylamino)benzamide O=C(Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3)OCc4ccccc4 COMAS Library NA NA NA 2.1 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002340 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV236 4-(4-ethoxybenzenesulfonamido)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamide CCOc1ccc(cc1)[S](=O)(=O)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002341 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV243 4-(cyclopropylsulfamoyl)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamide O=C(NCc1coc(n1)c2sccc2)c3ccc(cc3)[S](=O)(=O)NC4CC4 COMAS Library NA NA NA 5.9 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002342 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV224 4-(dimethylsulfamoyl)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamide CN(C)[S](=O)(=O)c1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3 COMAS Library NA NA NA 6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002343 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV245 4-methanesulfonamido-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamide C[S](=O)(=O)Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3 COMAS Library NA NA NA 8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002344 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA AV235 4-Acetamido-N-((2-(thiophen-2-yl)oxazol-4-yl)methyl)benzamide CC(=O)Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3 COMAS Library NA NA NA 9.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002345 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV145 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Isopropyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamide CC(C)n1ncc2cc(cnc12)C(=O)NCc3coc(n3)c4sccc4 COMAS Library 98% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002346 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV280 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3,4-dimethylbenzyl)-1H-pyrazolo[3,4-b]pyridine5-carboxamide (AV280) Cc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1C COMAS Library 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002347 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV286 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzylaminocarbonylamino)benzamide O=C(NCc1ccccc1)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4 COMAS Library 55% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002348 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV321 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(2-(3-(But-3-ynyl)-3H-diazirin-3- yl)ethyloxycarbonylamino)benzamide O=C(Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3)OCCC4(CCC#C)N=N4 COMAS Library 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002349 26566002 Hsp100 ClpXP Bacteria Cytosol Inhibition of protease activity NA AV286 N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzylaminocarbonylamino)benzamide O=C(NCc1ccccc1)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4 COMAS Library NA NA NA 2.1 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA NA Bacterial infection HSPMDB002350 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C2 COMAS Library NA NA NA 10.1 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002351 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C3 COMAS Library NA NA NA 21.1 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002352 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C4 COMAS Library NA NA NA 51.2 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002353 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C5 COMAS Library NA NA NA 78.1 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002354 26566002 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA AV287 N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamide CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C6 COMAS Library NA NA NA >95 NA NA NA NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA Bacterial infection HSPMDB002355 25944857 Hsp100 ClpP1P2 Human Cytosol NA Antibacterial activity 100, (Bortezomib) [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 90% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002356 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity 100, (Bortezomib) [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 90% at 3 uM Bacterial growth inhibition assay (OD based) NA NA NA M. bovis Tuberculosis HSPMDB002357 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity 100, (Bortezomib) [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 30% Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002358 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity 100, (Bortezomib) + Amikacin [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 90% Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002359 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity 100, (Bortezomib) + streptomycin [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O PHARMAKON1600 library NA NA NA NA NA NA NA NA Nucleotide binding domain NA 95% Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002360 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity Bz-al (2S)-N-[(2S)-4-methyl-1-oxopentan-2-yl]-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamide CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)C=O Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 5% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002361 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity CEP-18770 (Delanzomib) [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenylpyridine-2-carbonyl)amino]butanoyl]amino]-3-methylbutyl]boronic acid B(C(CC(C)C)NC(=O)C(C(C)O)NC(=O)C1=CC=CC(=N1)C2=CC=CC=C2)(O)O Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 80% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002362 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity MG-262 [(1R)-3-methyl-1-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)(O)O Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 45% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002363 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity MG-132 benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 10% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002364 25944857 Hsp100 ClpP1P2 Bacteria Cytosol NA Antibacterial activity MLN-2238 (Ixazomib) [(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O Bortezomib derivative NA NA NA NA NA NA NA NA Nucleotide binding domain NA 60% at 50 uM Bacterial growth inhibition assay (OD based) NA NA NA M. smegmatis (mc2155) Tuberculosis HSPMDB002365 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10001 1-[(3,5-difluorophenyl)methyl]-1-[(2E)-hept-2-enoyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea FC=1C=C(C=C(C1)F)CN(C(=O)N[C@@H]1C(N2CCC[C@H]2C(C2CCCC[C@H]2C(N[C@H](C(N2CCC[C@H]2C(OC1)=O)=O)C)=O)=O)=O)C(\C=C\CCCC)=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 100 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002366 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP2 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 25 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002367 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP3 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 100 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002368 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP4 1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]-1-[(2E)-hept-2-enoyl]urea CCCC\C=C\C(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C1=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 50 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002369 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10011 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C(=O)[C@H](COC(=O)[C@@H]2CCCN2C1=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 50 ug/ml (MIC99) M. tuberculosis (H37Rv) Tuberculosis HSPMDB002370 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10001 1-[(3,5-difluorophenyl)methyl]-1-[(2E)-hept-2-enoyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea FC=1C=C(C=C(C1)F)CN(C(=O)N[C@@H]1C(N2CCC[C@H]2C(C2CCCC[C@H]2C(N[C@H](C(N2CCC[C@H]2C(OC1)=O)=O)C)=O)=O)=O)C(\C=C\CCCC)=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 1 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002371 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP2 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 1.25 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002372 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP3 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA >100 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002373 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity ADEP4 1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]-1-[(2E)-hept-2-enoyl]urea CCCC\C=C\C(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C1=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 0.125 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002374 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10011 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C(=O)[C@H](COC(=O)[C@@H]2CCCN2C1=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA Nucleotide binding domain NA NA Bacterial growth inhibition assay (OD based) NA NA 5 ug/ml (MIC99) S. aureus Bacterial infection HSPMDB002375 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10001 1-[(3,5-difluorophenyl)methyl]-1-[(2E)-hept-2-enoyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea FC=1C=C(C=C(C1)F)CN(C(=O)N[C@@H]1C(N2CCC[C@H]2C(C2CCCC[C@H]2C(N[C@H](C(N2CCC[C@H]2C(OC1)=O)=O)C)=O)=O)=O)C(\C=C\CCCC)=O Acyldepsipeptide analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >100 ug/ml (MIC99) E. coli Bacterial infection HSPMDB002376 22123255 Hsp100 ClpP2 Bacteria Cytosol NA Antibacterial activity IDR-10011 1-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]urea C[C@@H]1NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C(=O)[C@H](COC(=O)[C@@H]2CCCN2C1=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1 Acyldepsipeptide analogue NA NA NA NA NA NA NA NA NA NA NA Bacterial growth inhibition assay (OD based) NA NA >100 ug/ml (MIC99) E. coli Bacterial infection HSPMDB002377 19206121 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA R1 trans-4-methyl-3-(8-nonen-1-yl)oxetan-2-one C[C@@H]1OC(=O)[C@H]1CCCCCCCC=C Beta lactone analogue NA NA NA 3 NA NA NA NA NA Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002378 19206121 Hsp100 ClpP Bacteria Cytosol Inhibition of protease activity NA U1 trans-3-(8-Nonen-1-yl)-4-pheneth-1-yloxetan-2-one CCC1(CC=CC=C1)[C@@H]2OC(=O)[C@H]2CCCCCCCC=C Beta lactone analogue NA NA NA 7 NA NA NA NA NA Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002379 26675528 Hsp100 ClpP Human Cytosol NA Antiproliferative activity Cisplatin dichloroplatinumdiamine N.N.Cl[Pt]Cl Chemical compound NA NA NA NA NA NA NA NA NA NA <50% Bacterial growth inhibition assay (OD based) NA NA NA HeLa Cancer HSPMDB002380 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA DFP Diisopropyl fluorophosphate CC(C)O[P](F)(=O)OC(C)C Chemical compound 95% NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002381 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COc1ccc(cc1)C2C(CCCC#C)OC2=O Chemical compound 98% NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002382 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS09 4-(4-ethynylbenzoyl)-2-(undec-10-enoyl)-1??,2-thiazetidine-1,1-dione C=CCCCCCCCCC(=O)N1CC(C(=O)c2ccc(cc2)C#C)[S]1(=O)=O Chemical compound 99% NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002383 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA DCI 3,4-Dichloroisocoumarine ClC1=C(Cl)c2ccccc2C(=O)O1 Chemical compound 60% at 25ºC for 1 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002384 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA CMK chloromethylketone CC(Cl)=O Chemical compound 85% at 25ºC for 1 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002385 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA FP Diisopropyl fluorophosphate CC(C)O[P](F)(=O)OC(C)C Chemical compound 60% at 25ºC for 1 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002386 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS02 2-(hex-5-ynoyl)-1??,2-thiazetidine-1,1-dione O=C(CCCC#C)N1CC[S]1(=O)=O Chemical compound 75% at 25ºC for 1 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002387 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA DCI 3,4-Dichloroisocoumarine ClC1=C(Cl)c2ccccc2C(=O)O1 Chemical compound 98% at 37ºC for 2 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002388 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA CMK chloromethylketone CC(Cl)=O Chemical compound 98% at 37ºC for 2 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002389 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA FP Diisopropyl fluorophosphate CC(C)O[P](F)(=O)OC(C)C Chemical compound 99% at 37ºC for 2 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002390 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS02 2-(hex-5-ynoyl)-1??,2-thiazetidine-1,1-dione O=C(CCCC#C)N1CCS1(=O)=O Chemical compound 98% at 37ºC for 2 hr NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002391 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS07 2-acetyl-4-(4-ethynylbenzoyl)-1??,2-thiazetidine-1,1-dione CC(=O)N1CC(C(=O)C2=CC=C(C=C2)C#C)S1(=O)=O Chemical compound NA NA NA 0.98 at 1 uM NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002392 24106749 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA RKS07 2-acetyl-4-(4-ethynylbenzoyl)-1??,2-thiazetidine-1,1-dione CC(=O)N1CC(C(=O)C2=CC=C(C=C2)C#C)S1(=O)=O Chemical compound NA NA NA 0.98 at 0.4 uM NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002393 18847196 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA Lactone D3 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCCC#C)OC1=O Beta lactone analogue NA NA NA 6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002394 18847196 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA Lactone E2 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O Beta lactone analogue NA NA NA 4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002395 18847196 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA Lactone G2 4-(pent-4-yn-1-yl)-3-pentyloxetan-2-one CCCCCC1C(CCCC#C)OC1=O Beta lactone analogue NA NA NA 31 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002396 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.37 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002397 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-694 N,N’-dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Small molecule NA NA NA 2 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002398 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-485A N 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamine Fc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1 Small molecule NA NA NA 0.45 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002399 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-862 3-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazole CC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3 Small molecule NA NA NA 2.66 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002400 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-873 3-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridine Cc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=O Small molecule NA NA NA 0.03 uM at 60 uM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002401 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.36 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002402 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-694 N,N’-dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Small molecule NA NA NA 9.13 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002403 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-485A N 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamine Fc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1 Small molecule NA NA NA 2.47 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002404 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-862 3-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazole CC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3 Small molecule NA NA NA 2.79 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002405 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-873 3-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridine Cc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=O Small molecule NA NA NA 0.02 uM at 1 mM ATP NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002406 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 20.7 uM at 0 minute NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002407 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 1.13 uM at 7.5 minutes NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002408 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.504 uM at 15 minutes NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002409 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.196 uM at 30 minutes NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002410 23892893 Hsp100 p97 Yeast Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Inhibition of ATPase activity NA NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 0.166 uM at 60 minutes NA NA NA NA Nucleotide binding domain (D2) Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002411 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 3.5 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002412 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-694 N,N’-dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Small molecule NA NA NA 3.2 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002413 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-485A N 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamine Fc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1 Small molecule NA NA NA 2.8 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002414 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-862 3-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazole CC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3 Small molecule NA NA NA >10 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002415 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-873 3-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridine Cc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=O Small molecule NA NA NA 0.4 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HCT116 Cancer HSPMDB002416 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-859 2-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamide ClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1 Small molecule NA NA NA 3 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002417 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-694 N,N’-dibenzylquinazoline-2,4-diamine C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 Small molecule NA NA NA 3.6 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002418 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-485A N 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamine Fc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1 Small molecule NA NA NA 4.1 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002419 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-862 3-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazole CC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3 Small molecule NA NA NA >10 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002420 23892893 Hsp100 NA Human NA NA Antiproliferative activity NMS-873 3-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridine Cc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=O Small molecule NA NA NA 0.7 NA NA NA NA Nucleotide binding domain (D2) NA NA Luminescence based viability assay NA NA NA HeLa Cancer HSPMDB002421 23892893 Hsp100 p97 Bacteria Cytosol, Mitochondria, Endoplasmic reliculum, Nucleous Binding Affinity NA NMS-249 4-(5-cyclopentylsulfanyl-4-pyridin-3-yl-4H-[1,2,4]triazol-3-ylmethoxy)-benzoic acid methyl ester COC(=O)c1ccc(OCc2nnc(SC3CCCC3)n2c4cccnc4)cc1 Small molecule NA 1.03 NA NA NA NA NA NA Nucleotide binding domain (D2) Isothermal titration calorimetry (ITC) NA NA NA NA NA NA NA HSPMDB002422 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 1 N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamide CCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1 Library of small molecule structures NA NA NA 30 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002423 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 2 2,20,200-((1,3,5-Triazin-2,4,6-triyl)tris(sulfanediyl))-tris-(N-(furan-2-ylmethyl)acetamide) O=C(CNC(=O)OCc1ccccc1)N[C@@H](CCC(=O)OCc2ccccc2)C(=O)OCc3ccccc3 Library of small molecule structures NA NA NA 92 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002424 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 3 Dibenzyl ((benzyloxy)carbonyl)glycylglutamate C(C1=CC=CC=C1)OC(=O)NCC(=O)N[C@@H](CCC(=O)OCC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002425 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 4 N,N-(5-(Thiazol-2-ylcarbamoyl)-1,3-phenylene)bis(2-phenoxyacetamide) COc1ccc(CNC(=O)C(=O)N/N=C/c2oc(CN[S](=O)(=O)c3ccc(Br)cc3)cc2)cc1 Library of small molecule structures NA NA NA 88 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002426 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 5 (E)-2-(2-((5-(((4-Bromophenyl)sulfonamido)methyl)furan-2-yl)methylene)hydrazinyl)-N-(4-methoxybenzyl)-2-oxoacetamide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)c3ccccc3)n1 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002427 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 6 2-((6-Methyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4-yl)thio)-N-(2-phenylacetyl)acetohydrazide CCCCOc1ccc(c(C)c1)c2nn(cc2\C=C(C#N)\C(=O)NCc3occc3)c4ccccc4 Library of small molecule structures NA NA NA 26 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002428 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 7 (E)-3-(3-(4-Butoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-cyano-N-(furan-2-ylmethyl)acrylamide CCCOc1ccc(cc1F)c2nn(cc2\C=C\3SC(=S)N(CCc4ccccc4)C3=O)c5ccccc5 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002429 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 8 (Z)-5-((3-(3-Fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-phenethyl-2-thioxothiazolidin-4-one CCc1ccc(CSc2ncc(Cl)c(n2)C(=O)NCCC(=O)Nc3ccc(Cl)cc3)cc1 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002430 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 9 5-Chloro-N-(3-((4-chlorophenyl)amino)-3-oxopropyl)-2-((4-ethylbenzyl)thio)pyrimidine-4-carboxamide ClC=1C(=NC(=NC1)SCC1=CC=C(C=C1)CC)C(=O)NCCC(=O)NC1=CC=C(C=C1)Cl Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002431 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 10 N-(3-methoxyphenyl)-2-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}acetamide COC1=CC=CC(NC(=O)CSC2=NC3=C(C4=C(COC(C4)C(C)C)S3)C(=O)N2CCC2=CC=CC=C2)=C1 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002432 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 11 2-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}-N-(4-phenylbutan-2-yl)acetamide CC(CCC1=CC=CC=C1)NC(=O)CSC1=NC2=C(C3=C(COC(C3)C(C)C)S2)C(=O)N1CCC1=CC=CC=C1 Library of small molecule structures NA NA NA 23 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002433 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 12 N-Benzyl-2-((6-isopropyl-4-oxo-3-phenethyl-3,5,6,8-tetrahydro-4H-pyrano[40,30:4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide CCCC1=CC(=O)Oc2cc(OCC(=O)N[C@@H](CSCc3ccccc3)C(O)=O)ccc12 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002434 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 13 S-Benzyl-N-(2-((2-oxo-4-propyl-2H-chromen-7-yl)oxy)acetyl)-cysteine COc1ccc(cc1)C(=O)CSc2nc(C)cc(SCC(=O)N(N)C(=O)Cc3ccccc3)n2 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002435 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 22 2-(2-(2-(4-Methoxyphenyl)-2-oxoethylthio)-6-methylpyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazide COC1=CC=C(C=C1)C(CSC1=NC(=CC(=N1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O)C)=O Library of small molecule structures NA NA NA 34.7 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002436 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 23 2-(2-(2-(4-(Diethylamino)phenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)N3CCOCC3)n1 Library of small molecule structures NA NA NA 28.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002437 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 24 2-(6-Methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCCN3CCOCC3)n1 Library of small molecule structures NA NA NA 28.8 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002438 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 25 2-(6-Methyl-2-(2-morpholinoethylthio)pyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)c3ccc(cc3)C#N)n1 Library of small molecule structures NA NA NA 30.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002439 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 26 2-(2-(2-(4-Cyanophenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccccc4 Library of small molecule structures NA NA NA 37.4 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002440 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 30 1-Benzyl-6-oxo-2-(2-oxo-2-phenylethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide COc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 24 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002441 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 31 1-Benzyl-2-(2-(4-methoxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6 dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)NNC(=O)Cc4ccccc4 Library of small molecule structures NA NA NA 45 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002442 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 32 1-Benzyl-6-oxo-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(NCCCc1ccccc1)C2=CN=C(SCCN3CCOCC3)N(Cc4ccccc4)C2=O Library of small molecule structures NA NA NA 72.6 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002443 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 33 1-Benzyl-2-(2-morpholinoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide CCOC(=O)CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3 Library of small molecule structures NA NA NA 10.5 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002444 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 34 Ethyl-2-(1-benzyl-6-oxo-5-(3-phenylpropylcarbamoyl)-1,6-dihydropyrimidin-2-ylthio)acetate CCN(CC)c1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 58.3 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002445 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 35 1-Benzyl-2-(2-(4-(diethylamino)phenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide Oc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002446 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 36 1-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#N Library of small molecule structures NA NA NA 53 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002447 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 37 1-Benzyl-2-(2-(4-cyanophenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)N4CCOCC4 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002448 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 38 1-Benzyl-2-(2-morpholino-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide C(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)N1CCOCC1 Library of small molecule structures NA NA NA 46 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002449 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 40 Ethyl-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-pyrimidin-4-one-5-carboxylate CCOC(=O)C1=CN=C(NC1=O)SCCN2CCOCC2 Library of small molecule structures NA NA NA 42 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002450 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 41 Ethyl 2-(2-morpholinoethylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxylate O1CCN(CC1)CCSC=1NC(C(=CN1)C(=O)OCC)=O Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002451 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 42 Ethyl 2-(2-morpholinoethylthio)-1-(2-oxo-2-phenylethyl)-pyrimidin-4-one-5-carboxylate OC(=O)C1=CN=C2SC(=C(CN2C1=O)c3ccccc3)CN4CCOCC4 Library of small molecule structures NA NA NA 40 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002452 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 43 2-(Morpholinomethyl)-6-oxo-3-phenyl-4,6-dihydropyrimido[2,1-b][1,3]thiazine-7-carboxylic acid O1CCN(CC1)CC1=C(CN2C(S1)=NC=C(C2=O)C(=O)O)C2=CC=CC=C2 Library of small molecule structures NA NA NA >100 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002453 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 44 2-(2-Morpholinoethylthio)-N-(3-phenylpropyl)-pyrimidin-4-one-5-carboxamide CCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1 Library of small molecule structures NA NA NA 44 NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002454 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 1 N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamide C(C)C1=NN=C(S1)NC(CSC1=NN=C(N1CCOC)C1=CC2=CC=CC=C2C=C1O)=O Library of small molecule structures NA NA 12.1 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002455 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 2 2,2,2-((1,3,5-Triazin-2,4,6-triyl)tris(sulfanediyl))-tris-(N-(furan-2-ylmethyl)acetamide) O=C(CNC(=O)OCc1ccccc1)N[C@@H](CCC(=O)OCc2ccccc2)C(=O)OCc3ccccc3 Library of small molecule structures NA NA 38 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002456 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 4 N,N-(5-(Thiazol-2-ylcarbamoyl)-1,3-phenylene)bis(2-phenoxyacetamide) COc1ccc(CNC(=O)C(=O)N/N=C/c2oc(CN[S](=O)(=O)c3ccc(Br)cc3)cc2)cc1 Library of small molecule structures NA NA 36 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002457 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 6 2-((6-Methyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4-yl)thio)-N0-(2-phenylacetyl)acetohydrazide CCCCOc1ccc(c(C)c1)c2nn(cc2\C=C(C#N)\C(=O)NCc3occc3)c4ccccc4 Library of small molecule structures NA NA 11 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002458 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 11 2-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}-N-(4-phenylbutan-2-yl)acetamide CC(CCC1=CC=CC=C1)NC(=O)CSC1=NC2=C(C3=C(COC(C3)C(C)C)S2)C(=O)N1CCC1=CC=CC=C1 Library of small molecule structures NA NA 9 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002459 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 22 2-(2-(2-(4-Methoxyphenyl)-2-oxoethylthio)-6-methylpyrimidin-4-ylthio)-N0-(2-phenylacetyl)acetohydrazide CCN(CC)c1ccc(cc1)C(=O)CSc2nc(C)cc(SCC(=O)N(N)C(=O)Cc3ccccc3)n2 Library of small molecule structures NA NA 14.2 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002460 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 23 2-(2-(2-(4-(Diethylamino)phenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N0-(2-^phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)N3CCOCC3)n1 Library of small molecule structures NA NA 11.6 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002461 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 24 2-(6-Methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4-ylthio)-N0-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCCN3CCOCC3)n1 Library of small molecule structures NA NA 11.8 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002462 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 25 2-(6-Methyl-2-(2-morpholinoethylthio)pyrimidin-4-yl-thio)-N0-(2-phenylacetyl)acetohydrazide Cc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)c3ccc(cc3)C#N)n1 Library of small molecule structures NA NA 12.3 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002463 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 26 2-(2-(2-(4-Cyanophenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N0-(2-phenylacetyl)acetohydrazide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccccc4 Library of small molecule structures NA NA 15.3 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002464 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 30 1-Benzyl-6-oxo-2-(2-oxo-2-phenylethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide COc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA 10 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002465 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 31 1-Benzyl-2-(2-(4-methoxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6 dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)NNC(=O)Cc4ccccc4 Library of small molecule structures NA NA 18 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002466 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 32 1-Benzyl-6-oxo-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(NCCCc1ccccc1)C2=CN=C(SCCN3CCOCC3)N(Cc4ccccc4)C2=O Library of small molecule structures NA NA 29.5 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002467 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 33 1-Benzyl-2-(2-morpholinoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide CCOC(=O)CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3 Library of small molecule structures NA NA 2.3 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002468 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 34 Ethyl-2-(1-benzyl-6-oxo-5-(3-phenylpropylcarbamoyl)-1,6-dihydropyrimidin-2-ylthio)acetate CCN(CC)c1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA 23.8 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002469 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 36 1-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#N Library of small molecule structures NA NA 21.6 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002470 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 38 1-Benzyl-2-(2-morpholino-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide C(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)N1CCOCC1 Library of small molecule structures NA NA 18.8 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002471 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 40 Ethyl-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-pyrimidin-4-one-5-carboxylate CCOC(=O)C1=CN=C(NC1=O)SCCN2CCOCC2 Library of small molecule structures NA NA 17 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002472 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 42 Ethyl 2-(2-morpholinoethylthio)-1-(2-oxo-2-phenylethyl)-pyrimidin-4-one-5-carboxylate OC(=O)C1=CN=C2SC(=C(CN2C1=O)c3ccccc3)CN4CCOCC4 Library of small molecule structures NA NA 16 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002473 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol Inhibition of protease activity NA 44 2-(2-Morpholinoethylthio)-N-(3-phenylpropyl)-pyrimidin-4-one-5-carboxamide CCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1 Library of small molecule structures NA NA 18 NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA P. falciparum Malaria HSPMDB002474 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 1 N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamide C(C)C1=NN=C(S1)NC(CSC1=NN=C(N1CCOC)C1=CC2=CC=CC=C2C=C1O)=O Library of small molecule structures NA NA NA 27 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002475 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 6 2-((6-Methyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4-yl)thio)-N0-(2-phenylacetyl)acetohydrazide CCCCOc1ccc(c(C)c1)c2nn(cc2\C=C(C#N)\C(=O)NCc3occc3)c4ccccc4 Library of small molecule structures NA NA NA 75 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002476 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 11 2-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}-N-(4-phenylbutan-2-yl)acetamide CC(CCC1=CC=CC=C1)NC(=O)CSC1=NC2=C(C3=C(COC(C3)C(C)C)S2)C(=O)N1CCC1=CC=CC=C1 Library of small molecule structures NA NA NA 25 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002477 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 22 2-(2-(2-(4-Methoxyphenyl)-2-oxoethylthio)-6-methylpyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazide COC1=CC=C(C=C1)C(CSC1=NC(=CC(=N1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O)C)=O Library of small molecule structures NA NA NA 11.8 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002478 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 23 2-(2-(2-(4-(Diethylamino)phenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide C(C)N(C1=CC=C(C=C1)C(CSC1=NC(=CC(=N1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O)C)=O)CC Library of small molecule structures NA NA NA 12.14 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002479 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 24 2-(6-Methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazide CC1=CC(=NC(=N1)SCC(=O)N1CCOCC1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O Library of small molecule structures NA NA NA 17.3 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002480 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 25 2-(6-Methyl-2-(2-morpholinoethylthio)pyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide CC1=CC(=NC(=N1)SCCN1CCOCC1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O Library of small molecule structures NA NA NA 14.4 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002481 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 26 2-(2-(2-(4-Cyanophenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccccc4 Library of small molecule structures NA NA NA 12.4 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002482 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 30 1-Benzyl-6-oxo-2-(2-oxo-2-phenylethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide COc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 20 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002483 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 31 1-Benzyl-2-(2-(4-methoxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6 dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)NNC(=O)Cc4ccccc4 Library of small molecule structures NA NA NA 2.4 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002484 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 33 1-Benzyl-2-(2-morpholinoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide CCOC(=O)CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3 Library of small molecule structures NA NA NA 9 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002485 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 34 Ethyl-2-(1-benzyl-6-oxo-5-(3-phenylpropylcarbamoyl)-1,6-dihydropyrimidin-2-ylthio)acetate CCN(CC)c1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 15.9 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002486 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 35 1-Benzyl-2-(2-(4-(diethylamino)phenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide Oc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4 Library of small molecule structures NA NA NA 9.2 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002487 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 36 1-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#N Library of small molecule structures NA NA NA 9.2 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002488 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 37 1-Benzyl-2-(2-(4-cyanophenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide C(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)C1=CC=C(C=C1)C#N Library of small molecule structures NA NA NA 13.7 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002489 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 38 1-Benzyl-2-(2-morpholino-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide C(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)N1CCOCC1 Library of small molecule structures NA NA NA 11.7 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002490 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 40 Ethyl-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-pyrimidin-4-one-5-carboxylate C(C)OC(=O)C=1C(NC(=NC1)SCC(NNC(CC1=CC=CC=C1)=O)=O)=O Library of small molecule structures NA NA NA 82.5 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002491 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 42 Ethyl 2-(2-morpholinoethylthio)-1-(2-oxo-2-phenylethyl)-pyrimidin-4-one-5-carboxylate O1CCN(CC1)CCSC=1N(C=C(C(N1)=O)C(=O)OCC)CC(C1=CC=CC=C1)=O Library of small molecule structures NA NA NA 19 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002492 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 43 2-(Morpholinomethyl)-6-oxo-3-phenyl-4,6-dihydropyrimido[2,1-b][1,3]thiazine-7-carboxylic acid O1CCN(CC1)CC1=C(CN2C(S1)=NC=C(C2=O)C(=O)O)C2=CC=CC=C2 Library of small molecule structures NA NA NA 11 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002493 28917450 Hsp100 ClpP Plasmodium falciparum Cytosol NA Antiparasitic activity 44 2-(2-Morpholinoethylthio)-N-(3-phenylpropyl)-pyrimidin-4-one-5-carboxamide O1CCN(CC1)CCSC1=NC=C(C(N1)=O)C(=O)NCCCC1=CC=CC=C1 Library of small molecule structures NA NA NA 22 NA NA NA NA NA NA NA Parasite growth inhibition assay (SYBR green) NA NA NA P. falciparum Malaria HSPMDB002494 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3S,4S)-4-{2-[3-(dimethylamino)propanesulfonyl]ethyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002495 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3S,4S)-4-{3-[3-(dimethylamino)propanesulfonyl]propyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002496 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 3 (3S,4S)-4-{4-[3-(dimethylamino)propanesulfonyl]butyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002497 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 4 (3S,4S)-4-{5-[3-(dimethylamino)propanesulfonyl]pentyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002498 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 5 trimethyl(3-{3-[(2S,3S)-4-oxo-3-undecyloxetan-2-yl]propanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002499 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 trimethyl(3-{4-[(2S,3S)-4-oxo-3-undecyloxetan-2-yl]butanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@H]1[C@H](CCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 64% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002500 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 7 trimethyl(3-{5-[(2S,3S)-4-oxo-3-undecyloxetan-2-yl]pentanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@H]1[C@H](CCCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002501 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 8 (3S,4S)-4-(2-{[3-(dimethylamino)propyl]sulfanyl}ethyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCSCCCN(C)C)OC1=O Beta lactone analogue 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002502 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 9 (3S,4S)-4-(3-{[3-(dimethylamino)propyl]sulfanyl}propyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCSCCCN(C)C)OC1=O Beta lactone analogue 60% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002503 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 10 (3S,4S)-4-(4-{[3-(dimethylamino)propyl]sulfanyl}butyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCCSCCCN(C)C)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002504 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 11 (3S,4S)-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@H]1[C@H](CCCCCSCCCN(C)C)OC1=O Beta lactone analogue 99% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002505 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 12 (3R,4R)-4-{2-[3-(dimethylamino)propanesulfonyl]ethyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 63% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002506 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 13 (3R,4R)-4-{3-[3-(dimethylamino)propanesulfonyl]propyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 92% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002507 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 14 (3R,4R)-4-{4-[3-(dimethylamino)propanesulfonyl]butyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 87% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002508 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 15 (3R,4R)-4-{5-[3-(dimethylamino)propanesulfonyl]pentyl}-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone analogue 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002509 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 16 trimethyl(3-{3-[(2R,3R)-4-oxo-3-undecyloxetan-2-yl]propanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@@H]1[C@@H](CCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 93% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002510 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 17 trimethyl(3-{4-[(2R,3R)-4-oxo-3-undecyloxetan-2-yl]butanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@@H]1[C@@H](CCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 91% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002511 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 18 trimethyl(3-{5-[(2R,3R)-4-oxo-3-undecyloxetan-2-yl]pentanesulfonyl}propyl)azanium iodide [I-].CCCCCCCCCCC[C@@H]1[C@@H](CCCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone analogue 91% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002512 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 19 (3R,4R)-4-(2-{[3-(dimethylamino)propyl]sulfanyl}ethyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCSCCCN(C)C)OC1=O Beta lactone analogue 89% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002513 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 20 (3R,4R)-4-(3-{[3-(dimethylamino)propyl]sulfanyl}propyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCSCCCN(C)C)OC1=O Beta lactone analogue 74% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002514 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 21 (3R,4R)-4-(4-{[3-(dimethylamino)propyl]sulfanyl}butyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCCSCCCN(C)C)OC1=O Beta lactone analogue 94% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002515 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 22 (3R,4R)-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)-3-undecyloxetan-2-one CCCCCCCCCCC[C@@H]1[C@@H](CCCCCSCCCN(C)C)OC1=O Beta lactone analogue 85% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002516 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 23 but-3-yn-1-yl N-(2-phenylethyl)carbamate O=C(NCCC1=CC=CC=C1)OCCC#C Beta lactone analogue 8% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002517 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 4-(but-3-yn-1-yl)-3-(non-8-en-1-yl)oxetan-2-one C=CCCCCCCCC1C(CCC#C)OC1=O Beta lactone analogue 95% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002518 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 25 but-3-yn-1-yl N-pentylcarbamate CCCCCNC(=O)OCCC#C Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002519 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 26 [(but-3-yn-1-yloxy)(hydroxy)methyl](non-8-en-1-yl)amine OC(NCCCCCCCC=C)OCCC#C Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002520 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 27 methyl undec-10-enoate COC(=O)CCCCCCCCC=C Beta lactone analogue 4% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002521 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 28 tert-butyl undec-10-enoate CC(C)(C)OC(=O)CCCCCCCCC=C Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002522 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 (4S)-4-(but-3-yn-1-yl)-3-dodecyloxetan-2-one CCCCCCCCCCCCC1[C@H](CCC#C)OC1=O Beta lactone analogue 5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002523 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 (3R)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@H]1CCC1=CC=CC=C1 Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002524 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 31 (3S)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@@H]1CCC1=CC=CC=C1 Beta lactone analogue 94% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002525 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 3-(oct-7-en-1-yl)-4-(2-phenylethyl)oxetan-2-one C=CCCCCCCC1C(CCC2=CC=CC=C2)OC1=O Beta lactone analogue 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002526 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 33 3-(oct-7-en-1-yl)-4-[2-(pyridin-3-yl)ethyl]oxetan-2-one C=CCCCCCCC1C(CCC2=CN=CC=C2)OC1=O Beta lactone analogue 100% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002527 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 34 4-[2-(pyridin-3-yl)ethyl]-3-undecyloxetan-2-one CCCCCCCCCCCC1C(CCC2=CN=CC=C2)OC1=O Beta lactone analogue 5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002528 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 35 4-(dimethylamino)-N-{5-[3-(oct-7-en-1-yl)-4-oxooxetan-2-yl]pentyl}benzamide CN(C)C1=CC=C(C=C1)C(=O)NCCCCCC1OC(=O)C1CCCCCCC=C Beta lactone analogue 70% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002529 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 36 tert-butyl N-{11-[3-(oct-7-en-1-yl)-4-oxooxetan-2-yl]undecyl}carbamate CC(C)(C)OC(=O)NCCCCCCCCCCCC1OC(=O)C1CCCCCCC=C Beta lactone analogue 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002530 25937012 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 37 tert-butyl N-{8-[2-(non-8-en-1-yl)-4-oxooxetan-3-yl]octyl}carbamate CC(C)(C)OC(=O)NCCCCCCCCC1C(CCCCCCCC=C)OC1=O Beta lactone analogue 5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA NA HSPMDB002531 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3S,4S)-3-decyl-4-{2-[3-(dimethylamino)propanesulfonyl]ethyl}oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone (library of enantiopure) 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002532 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3S,4S)-3-decyl-4-{3-[3-(dimethylamino)propanesulfonyl]propyl}oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone (library of enantiopure) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002533 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 3 (3S,4S)-3-decyl-4-{4-[3-(dimethylamino)propanesulfonyl]butyl}oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone (library of enantiopure) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002534 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 5 (3-{3-[(2S,3S)-3-decyl-4-oxooxetan-2-yl]propanesulfonyl}propyl)trimethylazanium iodide [I-].CCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone (library of enantiopure) 93% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002535 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 7 (3-{5-[(2S,3S)-3-decyl-4-oxooxetan-2-yl]pentanesulfonyl}propyl)trimethylazanium iodide [I-].CCCCCCCCCC[C@H]1[C@H](CCCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone (library of enantiopure) 93% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002536 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 8 (3S,4S)-3-decyl-4-(2-{[3-(dimethylamino)propyl]sulfanyl}ethyl)oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure) 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002537 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 10 (3S,4S)-3-decyl-4-(4-{[3-(dimethylamino)propyl]sulfanyl}butyl)oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCCCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure) 90% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002538 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 11 (3S,4S)-3-decyl-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)oxetan-2-one CCCCCCCCCC[C@H]1[C@H](CCCCCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure) 85% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002539 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 22 (3R,4R)-3-decyl-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)oxetan-2-one CCCCCCCCCC[C@@H]1[C@@H](CCCCCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure) 50% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002540 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 3-decyloxetan-2-one CCCCCCCCCCC1COC1=O Beta lactone (library of enantiopure) 10% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002541 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 3-decyloxetan-2-one CCCCCCCCCCC1COC1=O Beta lactone (library of enantiopure) 50% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002542 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 30 3-decyloxetan-2-one CCCCCCCCCCC1COC1=O Beta lactone (library of enantiopure) 45% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002543 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 31 4-decyloxetan-2-one CCCCCCCCCCC1CC(=O)O1 Beta lactone (library of enantiopure) 1% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002544 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 31 4-decyloxetan-2-one CCCCCCCCCCC1CC(=O)O2 Beta lactone (library of enantiopure) 1% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002545 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 31 4-decyloxetan-2-one CCCCCCCCCCC1CC(=O)O3 Beta lactone (library of enantiopure) 5% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002546 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 3-(2-phenylethyl)oxetan-2-one O=C1OCC1CCC1=CC=CC=C1 Beta lactone (library of enantiopure) 20% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002547 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 3-(2-phenylethyl)oxetan-2-one O=C1OCC1CCC1=CC=CC=C2 Beta lactone (library of enantiopure) 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002548 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 32 3-(2-phenylethyl)oxetan-2-one O=C1OCC1CCC1=CC=CC=C3 Beta lactone (library of enantiopure) 95% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002549 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 33 4-(2-phenylethyl)oxetan-2-one O=C1CC(CCC2=CC=CC=C2)O1 Beta lactone (library of enantiopure) 1% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002550 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 33 4-(2-phenylethyl)oxetan-2-one O=C1CC(CCC2=CC=CC=C2)O2 Beta lactone (library of enantiopure) 2% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002551 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 33 4-(2-phenylethyl)oxetan-2-one O=C1CC(CCC2=CC=CC=C2)O3 Beta lactone (library of enantiopure) 1% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002552 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 34 (3R)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@H]1CCC1=CC=CC=C1 Beta lactone (library of enantiopure) 0-5% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002553 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 34 (3R)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@H]1CCC1=CC=CC=C2 Beta lactone (library of enantiopure) 0-5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002554 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 34 (3R)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@H]1CCC1=CC=CC=C3 Beta lactone (library of enantiopure) 40% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002555 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 35 (3S)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@@H]1CCC1=CC=CC=C1 Beta lactone (library of enantiopure) 55% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002556 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 35 (3S)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@@H]1CCC1=CC=CC=C2 Beta lactone (library of enantiopure) 95% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002557 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 35 (3S)-3-(2-phenylethyl)oxetan-2-one O=C1OC[C@@H]1CCC1=CC=CC=C3 Beta lactone (library of enantiopure) 98% at 1000 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA NA Bacterial infection HSPMDB002558 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one [H]C(=C)CCCCCCCC1C(CCCC#C)OC1=O Beta lactone (library of enantiopure) 5% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002559 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 (3S,4S)-4-(pent-4-yn-1-yl)-3-tridecyloxetan-2-one CCCCCCCCCCCCC[C@H]1[C@H](CCCC#C)OC1=O Beta lactone (library of enantiopure) 13% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002560 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one [H]C(=C)CCCCCCCC1C(CCCC#C)OC1=O Beta lactone (library of enantiopure) 80% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA E. coli Bacterial infection HSPMDB002561 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 (3S,4S)-4-(pent-4-yn-1-yl)-3-tridecyloxetan-2-one CCCCCCCCCCCCC[C@H]1[C@H](CCCC#C)OC1=O Beta lactone (library of enantiopure) 15% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA E. coli Bacterial infection HSPMDB002562 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 24 3-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one [H]C(=C)CCCCCCCC1C(CCCC#C)OC1=O Beta lactone (library of enantiopure) 70% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002563 23361916 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 29 (3S,4S)-4-(pent-4-yn-1-yl)-3-tridecyloxetan-2-one CCCCCCCCCCCCC[C@H]1[C@H](CCCC#C)OC1=O Beta lactone (library of enantiopure) 20% at 100 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002564 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3R,4R)-3-(8-Nonenyl)-4-(2-phenylethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC1=CC=CC=C1)=O Beta lactone analogue 30% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002565 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3R,4R)-3-(8-Nonenyl)-4-(2-(3-pyridyl)ethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC=1C=NC=CC1)=O Beta lactone analogue 90% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002566 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 4 (3R,4R)-4-(4-(N,N-Dimethylamino)benzamido-5-pentyl)-3-(non-8-enyl)oxetan-2-one CN(C)C1=CC=C(C(=O)NC(CCCC)[C@H]2[C@H](C(O2)=O)CCCCCCCC=C)C=C1 Beta lactone analogue 55% at 10 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002567 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3R,4R)-3-(8-Nonenyl)-4-(2-phenylethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC1=CC=CC=C1)=O Beta lactone analogue 30% at 20 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002568 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3R,4R)-3-(8-Nonenyl)-4-(2-(3-pyridyl)ethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC=1C=NC=CC1)=O Beta lactone analogue 92% at 20 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002569 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 4 (3R,4R)-4-(4-(N,N-Dimethylamino)benzamido-5-pentyl)-3-(non-8-enyl)oxetan-2-one CN(C)C1=CC=C(C(=O)NC(CCCC)[C@H]2[C@H](C(O2)=O)CCCCCCCC=C)C=C1 Beta lactone analogue 65% at 20 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002570 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 1 (3R,4R)-3-(8-Nonenyl)-4-(2-phenylethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC1=CC=CC=C1)=O Beta lactone analogue 25% at 40 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002571 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 2 (3R,4R)-3-(8-Nonenyl)-4-(2-(3-pyridyl)ethyl)oxetan-2-one C(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC=1C=NC=CC1)=O Beta lactone analogue 90% at 40 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002572 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 4 (3R,4R)-4-(4-(N,N-Dimethylamino)benzamido-5-pentyl)-3-(non-8-enyl)oxetan-2-one CN(C)C1=CC=C(C(=O)NC(CCCC)[C@H]2[C@H](C(O2)=O)CCCCCCCC=C)C=C1 Beta lactone analogue 50% at 40 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002573 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 (3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-one C(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=O Beta lactone analogue 12% at 200 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002574 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 (3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-one C(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=O Beta lactone analogue 15% at 400 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002575 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 (3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-one C(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=O Beta lactone analogue 20% at 600 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002576 21855356 Hsp100 ClpP Bacteria Cytosol Inhibition of peptidase activity NA 6 (3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-one C(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=O Beta lactone analogue 10% at 800 uM NA NA NA NA NA NA NA Nucleotide binding domain Peptidase assay (SLY-AMC) NA NA NA NA NA S. aureus Bacterial infection HSPMDB002577 30543804 Hsp100 ClpP1P2 Bacteria Cytosol Inhibition of protease activity NA DCC Dicyclohexylcarbodiimide C1CCC(CC1)N=C=NC2CCCCC2 GSK Library collection NA NA NA 80 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB002578 30543804 Hsp100 ClpC1 Bacteria Cytosol Inhibition of protease activity NA ecumicin (2S,3R)-2-[[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-N-[(3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,31R)-27-[(1R)-1-hydroxyethyl]-6-[(R)-hydroxy(phenyl)methyl]-12-[(4-methoxy-1H-indol-3-yl)methyl]-13,16,22,28,31-pentamethyl-21-(2-methylpropyl)-2,5,8,11,14,17,20,23,26,29-decaoxo-3,9,15,18,24-penta(propan-2-yl)-1-oxa-4,7,10,13,16,19,22,25,28-nonazacyclohentriacont-30-yl]-3-methylpentanamide CCC(C)C(C(=O)NC1C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N(C(=O)C(N(C(=O)C(NC(=O)C(N(C(=O)C(NC(=O)C(N(C1=O)C)C(C)O)C(C)C)C)CC(C)C)C(C)C)C)C(C)C)C)CC2=CNC3=C2C(=CC=C3)OC)C(C)C)C(C4=CC=CC=C4)O)C(C)C)C)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C GSK Library collection NA NA NA 4 NA NA NA NA Nucleotide binding domain Substrate degradation assay (GFP-ssrA) NA NA NA NA NA M. tuberculosis (H37Rv) Tuberculosis HSPMDB002579 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-02 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.08 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002580 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-10 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.07 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002581 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-18 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.06 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002582 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-06 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC(F)=CC(F)=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.04 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002583 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-15 NA O=C([C@H](C)NC([C@@](CCC1)([H])N1C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.04 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002584 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-20 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC=C3)NC(/C=C/CCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.03 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002585 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-32 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CN4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.03 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002586 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-04 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.02 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002587 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-13 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.02 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002588 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-17 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CCCCC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.02 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002589 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-21 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3CCCCC3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 1.00 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002590 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-14 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C=C/CCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.99 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002591 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-30 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.98 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002592 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-05 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.98 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002593 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-25 NA O=C([C@H](CC)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.97 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002594 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-08 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.97 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002595 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-41 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.96 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002596 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-01 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.96 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002597 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-28 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.95 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002598 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-38 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.95 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002599 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-37 NA O=C([C@H](C)NC([C@@]1([H])N(CCC2=C1C=CC=C2)C([C@@]3([H])N(C([C@@H](NC([C@H](CC4=CC(F)=CC(F)=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC3)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002600 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-29 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002601 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-43 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(C=CC=C4)=C4C=C3)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.87 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002602 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-42 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CSC4=C3C=CC=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.87 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002603 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-26 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.86 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002604 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-39 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C4=CC=CC(C(F)(F)F)=C4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.78 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002605 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-11 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.77 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002606 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-09 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.76 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002607 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-03 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.66 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002608 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-27 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C#CCCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.64 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002609 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-07 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCCC(O)=O)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.61 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002610 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-44 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C4=CC=CC=C4C(F)(F)F)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.42 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002611 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-12 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C#CCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.36 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002612 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-19 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C\CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.34 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002613 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-45 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC(C(F)=C3F)=C(F)C(F)=C3F)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.29 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002614 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-23 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C#CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.12 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002615 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-33 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C\CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.07 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002616 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-16 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OCC3=CC=CC=C3)=O)=O)CO4)=O)CCC1)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.06 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002617 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-46 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/COC3([H])OCCCC3)=O)=O)CO4)=O)CCC1)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.02 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002618 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-36 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/CO)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002619 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-24 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(C4=CC=C([N+]([O-])=O)C=C4)=O)=O)CO5)=O)CCC2)=O)=O)N6CCC[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 1 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002620 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-34 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OC(C)(C)C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 2 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002621 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-35 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OC(C)(C)C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 3 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002622 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-31 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)N)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 4 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002623 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-22 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OCC3=CC=CC=C3)=O)=O)CO4)=O)CCC1)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 5 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002624 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-40 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)N)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 6 at 25 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002625 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-32 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CN4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.9 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002626 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-06 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC(F)=CC(F)=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.94 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002627 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-30 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.93 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002628 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-41 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.93 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002629 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-28 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.93 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002630 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-25 NA O=C([C@H](CC)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002631 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-14 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C=C/CCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002632 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-15 NA O=C([C@H](C)NC([C@@](CCC1)([H])N1C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.92 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002633 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-13 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.91 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002634 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-17 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CCCCC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.91 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002635 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-20 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC=C3)NC(/C=C/CCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.90 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002636 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-38 NA O=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.89 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002637 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-02 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.88 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002638 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-29 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.87 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002639 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-37 NA O=C([C@H](C)NC([C@@]1([H])N(CCC2=C1C=CC=C2)C([C@@]3([H])N(C([C@@H](NC([C@H](CC4=CC(F)=CC(F)=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC3)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.86 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002640 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-10 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.85 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002641 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-04 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.78 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002642 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-18 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.72 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002643 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-21 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3CCCCC3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.70 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002644 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-01 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.70 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002645 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-05 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.69 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002646 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-43 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(C=CC=C4)=C4C=C3)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.55 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002647 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-08 NA O=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.52 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002648 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-42 NA O=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CSC4=C3C=CC=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=O Acyldepsipeptide analogue NA NA NA NA NA NA 0.49 at 5 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002649 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-17 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CC5CCCCC5)=O)CC6=CC(F)=CC(F)=C6)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.81 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002650 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-28 NA O=C(N1CCC[C@]12[H])[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CC[C@@H](C3)C)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.82 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002651 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-14 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/C=C/CCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.79 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002652 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-41 NA O=C(N1CCC[C@]12[H])[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.79 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002653 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-32 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](CNC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.79 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002654 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-29 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.76 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002655 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-38 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CC[C@@H](C3)C)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.76 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002656 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-30 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CC[C@@H](C3)C)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.69 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002657 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-37 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCC6=C3C=CC=C6)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.68 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002658 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-06 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@@H](N(C([C@]3(N(CCC3)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC4=CC(F)=CC(F)=C4)=O)=O)[H])=O)C)C)=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.64 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002659 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-25 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)CC Acyldepsipeptide analogue NA NA NA NA NA NA 0.61 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002660 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-13 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CC5CC5)=O)CC6=CC(F)=CC(F)=C6)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.59 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002661 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-15 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3([H])CCCN3C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.58 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002662 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-20 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCC)=O)CC5=CC(F)=CC=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.53 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002663 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-02 NA O=C(N1CCC[C@]12[H])[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC5=CC=CC=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.52 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002664 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-10 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC5=CC=CC=C5)=O)=O)[H])=O)CCCC3)[H])=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.44 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002665 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-04 NA O=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@@H](N(C([C@]3(N(CCC3)C([C@H](COC2=O)NC([C@H](NC(/C=C/C=C/CCC)=O)CC4=CC=CC=C4)=O)=O)[H])=O)C)C)=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.32 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA HSPMDB002666 30126533 Hsp100 ClpP Human Mitochondria Inhibition of protease activity NA ADEP-01 NA O=C(N1CCC[C@]12[H])[C@@H](NC([C@@H](N(C([C@]3(N(CCC3)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC4=CC=CC=C4)=O)=O)[H])=O)C)C)=O)C Acyldepsipeptide analogue NA NA NA NA NA NA 0.22 at 1 uM NA Nucleotide binding domain Substrate degradation assay (FITC-casein) NA NA NA NA NA NA NA