HSPMdb Accession NoHSPMDB001482
PMID20481474
TargetHsp70
HSP NameDnaK
OrganismBacteria
LocalizationCytosol and membrane
Enzymatic activityActivation of chaperone activity
Compound Name115-7c
IUPAC Name4-{5-[(benzyloxy)carbonyl]-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl}butanoic acid
SMILESCC1=C(C(NC(=O)N1CCCC(O)=O)C1=C(Cl)C=C(Cl)C=C1)C(=O)OCC1=CC=CC=C1
ClassDihydropyrimidine derivative
% Enzymatic Inhibition/Fold Change2 fold at 1 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayRefolding assay (luciferase)

Structure



HSPMDB001482

115-7c

Physicochemical Properties