| HSPMdb Accession No | HSPMDB001466 |
| PMID | 28615625 |
| Target | Hsp70 |
| HSP Name | Hsc70 (HSPA8) |
| Organism | Human |
| Localization | Cytosol and nucleus |
| Cellular activity | Antiproliferative activity |
| Compound Name | Az-O3-Imatinib |
| IUPAC Name | 4-{[4-(2-{[(2-{[4-({2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl}methyl)phenyl]formamido}ethoxy)methoxy]methoxy}ethyl)piperazin-1-yl]methyl}-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide |
| SMILES | COC1=CC=C(C=C1)C1=C(N(CC2=CC=C(C=C2)C(=O)NCCOCOCOCCN2CCN(CC3=CC=C(C=C3)C(=O)NC3=CC(NC4=NC(=CC=N4)C4=CC=CN=C4)=C(C)C=C3)CC2)C(=N1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CC=C(OC)C=C1 |
| Class | Hybrid of HSP70 and HSP90 inhibitor |
| IC50 (µM) | >10 |
| Site of Interaction | Nucleotide binding domain |
| Cellular assay | MTT viability assay |
| Cellular Model | U937 |
| Disease | Cancer |
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